Cefepime: A rare cause of encephalopathy

Internal Medicine Journal

Volumn 42, Issue 6, 2012, Pages 732-733

  McNally, A ^a   Pithie, A ^a   Jardine, D ^a  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; CEFEPIME;

ACUTE KIDNEY FAILURE; AGED; APNEA; ARTIFICIAL VENTILATION; BRAIN DISEASE; CASE REPORT; CONFUSION; DEHYDRATION; DIFFERENTIAL DIAGNOSIS; DRUG INDUCED DISEASE; DYSPHASIA; FEMALE; HEPATIC ENCEPHALOPATHY; HUMAN; INTENSIVE CARE; LETTER; MYOCLONUS; OLIGURIA; OSTEOMYELITIS; PRIORITY JOURNAL; PSEUDOMONAS INFECTION; SEPSIS; STUPOR;

ACUTE KIDNEY INJURY; AGED; ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; NEUROTOXICITY SYNDROMES; OSTEOMYELITIS; PSEUDOMONAS INFECTIONS; RESPIRATION, ARTIFICIAL;

EID: 84862511743     PISSN: 14440903     EISSN: 14455994     Source Type: Journal    
DOI: 10.1111/j.1445-5994.2012.02800.x     Document Type: Letter

References (20)

1. Neu HC. Safety of cefepime: a new extended-spectrum parenteral cephalosporin. Am J Med 1996; 100: 68S-75S.
2. Lamoth F, Buclin T, Pascua A, Vora S, Bolay S, Decosterd LA etal. High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. Antimicrob Agents Chemother 2010; 54: 4360-7.
3. Okamoto MP, Nakahiro RK, Chin A, Bedikian A. Cefepime clinical pharmacokinetics. Clin Pharmacokinet 1993; 25: 88-102.
4. Barbhaiya RH, Knupp CA, Forgue ST, Guay DR, Pittman KA. Pharmacokinetics of cefepime in subjects with renal insufficiency. Clin Pharmacol Ther 1990; 48: 268-76.
5. Lin CJ, Chen SP, Wang SJ, Fuh JL. Cefepime-related encephalopathy in peritoneal dialysis patients. J Chin Med Assoc 2011; 74: 87-90.
6. Martín Herrera C, Navarro M. Cefepime-induced encephalopathy in patients with renal failure. Nefrologia 2009; 29: 181.
7. Sonck J, Laureys G, Verbeelen D. The neurotoxicity and safety of treatment with cefepime in patients with. Ren Fail 2008; 23: 966-70.
8. Garces EO, Andrade de Anzambuja MF, da Silva D, Bragatti JA, Jacoby T, Saldanha Thomé F. Renal failure is a risk factor for cefepime-induced encephalopathy. J Nephrol 2008; 21: 526-34.
9. De Silva DA, Pan AB, Lim SH. Cefepime-induced encephalopathy with triphasic waves in three Asian patients. Ann Acad Med Singapore 2007; 36: 450-1.
10. Capparelli FJ, Diaz MF, Hlavnika A, Wainsztein NA, Leiguarda R, Del Castillo ME. Cefepime- and cefixime-induced encephalopathy in a patient with normal renal function. Neurology 2005; 65: 1840.
11. Magnati R, Jolin D, Rishi D, Biswas A. Nonconvulsive status epilepticus due to cefepime in a patient with normal renal function. Epilepsy Behav 2006; 8: 312-14.
12. Abanades S, Nolla J, Rodriguez-Campello A, Pedro C, Valls A, Farre M. Reversible coma secondary to cefepime neurotoxicity. Ann Pharmacother 2004; 38: 606-8.
13. Chow KM, Szeto CC, Hui AC, Wong TY, Li PK. Retrospective review of neurotoxicity induced by cefepime and ceftazidime. Pharmacotherapy 2003; 23: 369-73.
14. Chatellier D, Jourdain M, Mangalaboyi J, Ader F, Chopin C, Derambure P etal. Cefepime-induced neurotoxicity: an underestimated complication of antibiotherapy in patients with acute renal failure. Intensive Care Med 2002; 28: 214-7.
15. Jallon P, Fankhauser L, Du Pasquier R, Coeytaux A, Picard F, Hefft S etal. Severe but reversible encephalopathy associated with cefepime. Neurophysiol Clin 2000; 30: 383-6.
16. Dakdouki GK, Al-Awar GN. Cefepime-induced encephalopathy. Int J Infect Dis 2004; 8: 59-61.
17. Sugimoto M, Uchida I, Mashimo T, Yamazaki S, Hatano K, Ikeda F etal. Evidence for the involvement of GABA(A) receptor blockade in convulsions induced by cephalosporins. Neuropharmacology 2003; 45: 304-14.
18. Drago L, De Vecchi E. The safety of cefepime in the treatment of infection. Expert Opin Drug Saf 2008; 7: 377-87.
19. Yahav D, Paul M, Fraser A, Sarid N, Leibovici L. Efficacy and safety of cefepime: a systematic review and meta-analysis. Lancet Infect Dis 2007; 7: 338-48.
20. Kim PW, Wu YT, Cooper C, Rochester G, Valappil T, Wang Y etal. Meta-analysis of a possible signal of increased mortality associated with cefepime use. Clin Infect Dis 2010; 51: 381-9.