Trypanosomes contain two highly different isoforms of peroxin PEX13 involved in glycosome biogenesis

FEBS Letters

Volumn 586, Issue 13, 2012, Pages 1765-1771

  Brennand, Ana ^a   Rigden, Daniel J ^b   Michels, Paul A M ^a  

^a DE DUVE INSTITUTE   (Belgium)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Biogenesis; Docking complex; Glycosome; Peroxin; Peroxisome; Trypanosoma

Indexed keywords

ISOPROTEIN; PEROXIN; PEROXIN 13; PEROXIN 13.1; PEROXIN 13.2; UNCLASSIFIED DRUG;

ALGORITHM; ARTICLE; BIOGENESIS; DATA BASE; GLYCOSOME; KINETOPLASTIDA; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; RNA INTERFERENCE; SEARCH ENGINE; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

AMINO ACID SEQUENCE; BIOGENESIS; MICROBODIES; MOLECULAR SEQUENCE DATA; PEROXISOMES; PROTEIN ISOFORMS; PROTOZOAN PROTEINS; RNA INTERFERENCE; SEQUENCE ALIGNMENT; SRC HOMOLOGY DOMAINS; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMATIDAE;

EID: 84862499073     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.05.019     Document Type: Article

References (28)

1. Moreira, D., López-García, P. and Vickerman, K. (2004) An updated view of kinetoplastid phylogeny using environmental sequences and a closer outgroup: proposal for a new classification of the class Kinetoplastea. Int. J. Syst. Evol. Microbiol. 54, 1861-1875. (Pubitemid 39360009)
2. Opperdoes, F.R. and Borst, P. (1977) Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome. FEBS Lett. 80, 360-364. (Pubitemid 8168985)
3. Michels, P.A.M., Bringaud, F., Herman, M. and Hannaert, V. (2006) Metabolic functions of glycosomes in trypanosomatids. Biochim. Biophys. Acta 1763, 1463-1477. (Pubitemid 44880465)
4. Moyersoen, J., Choe, J., Fan, E., Hol, W.G.J. and Michels, P.A.M. (2004) Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target. FEMS Microbiol. Rev. 28, 603-643. (Pubitemid 39469922)
5. Galland, N. and Michels, P.A.M. (2010) Comparison of the peroxisomal matrix protein import system of different organisms. Exploration of possibilities for developing inhibitors of the import system of trypanosomatids for antiparasite chemotherapy. Eur. J. Cell Biol. 89, 621-637.
6. Van der Klei, I.J. and Veenhuis, M. (2006) PTS1-independent sorting of peroxisomal matrix proteins by Pex5p. Biochim. Biophys. Acta 1763, 1794-1800.
7. Galland, N., de Walque, S., Voncken, F.G.J., Verlinde, C.L.M.J. and Michels, P.A.M. (2010) An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes. Mol. Biochem. Parasitol. 171, 45-49.
8. Meinecke, M., Cizmowski, C., Schliebs, W., Krüger, V., Beck, S., Wagner, R. and Erdmann, R. (2010) The peroxisomal importomer constitutes a large and highly dynamic pore. Nat. Cell Biol. 12, 273-277.
9. Verplaetse, E., Rigden, D.J. and Michels, P.A.M. (2009) Identification, characterisation and essentiality of the unusual peroxin 13 from Trypanosoma brucei. Biochim. Biophys. Acta 1793, 516-527.
10. Johnson, L.S., Eddy, S.R. and Portugaly, E. (2010) Hidden Markov model speed heuristic and iterative HMM search procedure. BMC Bioinformatics 11, 431.
11. Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W. and Lipman, D.J. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389-3402. (Pubitemid 27359211)
12. The UniProt Consortium (2012) Reorganizing the protein space at the Universal Protein Resource (UniProt). Nucleic Acids Res. 40, D71-75.
13. Gattiker, A., Gasteiger, E. and Bairoch, A. (2002) ScanProsite: a reference implementation of a PROSITE scanning tool. Appl. Bioinformatics 1, 107-108.
14. Krogh, A., Larsson, B., von Heijne, G. and Sonnhammer, E.L. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305, 567-580. (Pubitemid 33032862)
15. Waterhouse, A.M., Procter, J.B., Martin, D.M., Clamp, M. and Barton, G.J. (2009) Jalview Version 2-a multiple sequence alignment editor and analysis workbench. Bioinformatics 25, 1189-1191.
16. Wirtz, E., Leal, S., Ochatt, C. and Cross, G.A. (1999) A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol. Biochem. Parasitol. 99, 89-101. (Pubitemid 29127189)
17. Biebinger, S., Wirtz, L.E., Lorenz, P. and Clayton, C. (1997) Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma brucei. Mol. Biochem. Parasitol. 85, 99-112. (Pubitemid 27168008)
18. Brun, R. and Schönenberger, M. (1979) Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication. Acta Trop. 36, 289-292. (Pubitemid 10181444)
19. Yernaux, C., Fransen, M., Brees, C., Lorenzen, S. and Michels, P.A.M. (2006) Trypanosoma brucei glycosomal ABC transporters: identification and membrane targeting. Mol. Membr. Biol. 23, 157-172.
20. Schaffer, A.A., Aravind, L., Madden, T.L., Shavirin, S., Spouge, J.L., Wolf, Y.I., Koonin, E.V. and Altschul, S.F. (2001) Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements. Nucleic Acids Res. 29, 2994-3005. (Pubitemid 32685225)
21. Altschul, S.F., Wootton, J.C., Gertz, E.M., Agarwala, R., Morgulis, A., Schaffer, A.A. and Yu, Y.K. (2005) Protein database searches using compositionally adjusted substitution matrices. FEBS J. 272, 5101-5109. (Pubitemid 41503143)
22. Williams, C. and Distel, B. (2006) Pex13p: docking or cargo handling protein? Biochim. Biophys. Acta 1763, 1585-1591. (Pubitemid 44880481)
23. Chen, Y., Hung, C.H., Burderer, T. and Lee, G.S. (2003) Development of RNA interference revertants in Trypanosoma brucei cell lines generated with a double stranded RNA expression construct driven by two opposing promoters. Mol. Biochem. Parasitol. 126, 275-279. (Pubitemid 36255626)
24. Moyersoen, J., Choe, J., Kumar, A., Voncken, F.G.J., Hol, W.G.J. and Michels, P.A.M. (2003) Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins. Eur. J. Biochem. 270, 2059-2067. (Pubitemid 36560828)
25. Blattner, J., Helfert, S., Michels, P. and Clayton, C. (1998) Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism. Proc. Natl. Acad. Sci. USA 95, 11596-11600. (Pubitemid 28460460)
26. Furuya, T., Kessler, P., Jardim, A., Schnaufer, A., Crudder, C. and Parsons, M. (2001) Glucose is toxic to glycosome-deficient trypanosomes. Proc. Natl. Acad. Sci. USA 99, 14177-14182. (Pubitemid 35257645)
27. Haanstra, J.R., Van Tuijl, A., Kessler, P., Reijnders, W., Michels, P.A.M., Westerhoff, H.V., Parsons, M. and Bakker, B.M. (2008) Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes. Proc. Natl. Acad. Sci. USA 105, 17718-17723.
28. Girzalsky, W., Rehling, P., Stein, K., Kipper, J., Blank, L., Kunau, W.H. and Erdmann, R. (1999) Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes. J. Cell Biol. 144, 1151-1162. (Pubitemid 29157295)