Liver Fibrosis in Elderly Cadavers: Localization of Collagen Types I, III, and IV, α-Smooth Muscle Actin, and Elastic Fibers

Anatomical Record

Volumn 295, Issue 7, 2012, Pages 1159-1167

  Mak, Ki M ^a   Chu, Edward ^a   Lau, K H Vincent ^a   Kwong, Allison J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

smooth muscle actin; Collagens; Elastic fibers; Elderly cadaveric liver; Hepatic stellate cells; Myofibroblasts

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4;

AGED; ARTICLE; BASEMENT MEMBRANE; CADAVER; CELL FUNCTION; CENTRAL VEIN; CONTROLLED STUDY; ELASTIC FIBER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER FIBROSIS; LIVER PARENCHYMA; MYOFIBROBLAST; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STAINING; STELLATE CELL;

ACTINS; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CADAVER; CELLS, CULTURED; COLLAGEN TYPE I; COLLAGEN TYPE III; COLLAGEN TYPE IV; ELASTIC TISSUE; HEPATIC STELLATE CELLS; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER CIRRHOSIS; MYOFIBROBLASTS;

EID: 84862495921     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.22504     Document Type: Article

References (34)

1. Cassiman D, Libbrecht L, Desmet V, Denef C, Roskams T. 2002. Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 36: 200-209.
2. Clement B, Grimaud JA, Campion JP, Deugnier Y, Guillouzo A. 1986. Cell types involved in collagen and fibronectin production in normal and fibrotic human liver. Hepatology 6: 225-234.
3. Davis GL, Alter MJ, El-Serag H, Poynard T, Jennings LW. 2010. Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology 138: 513-521.
4. Desmet V, Roskams T, van Eyken P. 1995. Ductular reaction in the liver. Path Res Pract 191: 513-524.
5. Fox M, Fox J, Davies M. 2011. Diagnosis and management of chronic liver disease in older people. Rev Clin Gerontol 21: 1-15.
6. Friedman SL. 2003. Liver fibrosis-from bench to bedside. J Hepatol 38: S38-S53.
7. Friedman SL. 2008. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88: 125-172.
8. Frith J, Newton JL. 2010. Liver disease in older women. Maturitas 65: 210-214.
9. Gan, L, Chitturi S, Farrell GC. 2011. Mechanisms and implications of age-related changes in the liver: non-alcoholic fatty liver disease in the elderly. Curr Gerontol Geriatr Res 2011: 831536.
10. Geerts A, Schuppan D, Lazeroms S, De Zanger R, Wisse E. 1990. Collagen type I and III occur together in hybrid fibrils in the space of Disse of normal rat liver. Hepatology 12: 233-241.
11. Grimaud JA, Druguet M, Peyrol S, Chevalier O, Herbage D, El Badrawy N. 1980. Collagen immnuotyping in human liver: light and electron microscope study. J Histochem Cytochem 28: 1145-1156.
12. Gulubova MV. 2000. Ito cell morphology, α-smooth muscle actin and collagen IV expression in the liver of patients with gastric and colorectal tumors. Histochem J 32: 151-164.
13. Hahn E, Wick G, Pencev D, Timpl R. 1980. Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin. Gut 21: 63-71.
14. Junqueira LCU, Bignolas G, Brentani RR. 1979. Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 11: 447-455.
15. Lopez-De Leon A, Rojkind M. 1985. A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem 33: 737-743.
16. Lorena D, Darby IA, Reinhardt DP, Sapin V, Rosenbaum J, Desmouliere A. 2004. Fibrillin-1 expression in normal and fibrotic rat liver and in cultured hepatic fibroblastic cells: modulation by mechanical stress and role in cell adhesion. Lab Invest 84: 203-212.
17. Mak KM, Leo MA, Lieber CS. 1993. Transformation of fat-storing cells into transitional cells in alcoholic liver fibrosis. In: Surrenti C, Casini A, Milani S, Pinzani M, editors. International Falk Symposium 71. Fat-Storing Cells and Liver Fibrosis. Dordrecht/Boston, London: Kluwer Academic Publishers. p 167-179.
18. Mak KM, Lieber CS. 1985. Portal fibroblasts and myofibroblasts in baboons after chronic alcohol consumption. Arch Pathol Lab Med 110: 513-516.
19. Mak KM, Kwong AJ, Chu E, Hoo NM. 2012. Hepatic steatosis, fibrosis, and cancer in elderly cadavers. Anat Rec 295: 40-50.
20. Martin-Carbonero L, Benhamou Y, Puoti M, Berenquer J, Mallolas J, Quereda C, Arizcorreta A, Gonzalez A, Rockstroh J, Asensi V, Miralles P, Laguno M, Monero L, Giron JA, Vogel M, Garcia-Samaniego J, Nunez M, Romero M, Moreno S, de al Cruz JJ, Soriano V. 2004. Incidence and predictors of severe liver fibrosis in human immunodeficiency virus-infected patients with chronic hepatitis C: a European collaborative study. Clin Inf Dis 38: 128-133.
21. McLean AJ, Cogger VC, Chong GC, Warren A, Makus AMA, Dahlstrom E, Le Couteur DG. 2003. Age-related pseudocapillarization of the human liver. J Pathol 2003: 112-117.
22. Nakano M, Lieber CS. 1982a. Ultrastructure of initial stages of perivenular fibrosis in alcohol-fed baboons. 1982a. Am J Pathol 106: 145-155.
23. Nakano M, Worner TM, Lieber CS. 1982b. Perivenular fibrosis in alcoholic liver injury: ultrastructural and histologic progression. Gastroenterology 83: 777-785.
24. Nakayama H, Itoh H, Kunita S, Kuroda N, Hiroi M, Matsuura H, Yasui W, Enzan H. 2008. Presence of perivenular elastic fibers in nonalcoholic steatohepatitis fibrosis stage III. Histol Histopathol 23: 407-409.
25. Porto LC, Chevallier M, Guerret S, Hartmann DJ, Grimaud JA. 1990a. Elastin in alcoholic liver disease. An immunohistochemical and immunoelectron microscopic study. Pathol Res Pract 186: 668-679.
26. Porto LC, Chevallier M, Peyrol S, Guerret S, Grimaud JA. 1990b. Elastin in human, baboon, and mouse liver: an immunohistochemical and immunoelectron microscopic study. Anat Rec 228: 392-404.
27. Ramadori G, Saile B. 2004. Portal tract fibrogenesis in the liver. Lab Invest 84: 153-159.
28. Ren C, Paronetto F, Mak KM, Leo MA, Lieber CS. 2003. Cytokeratin 7 staining of hepatocytes predicts progression to more severe fibrosis in alcohol-fed baboons. J Hepatol 38: 770-775.
29. Rojkind M, Martinez-Palomo A. 1976. Increase in type I and type III collagens in human alcoholic liver cirrhosis. Proc Natl Acad Sci USA 73: 539-543.
30. Rudolph R, McClure WJ, Woodward M. 1979. Contractile fibroblasts in chronic alcoholic cirrhosis. Gastroenterology 44: 239-242.
31. Schaffner F, Popper H. 1963. Capillarization of hepatic sinusoids in man. Gastroenterology 44: 239-242.
32. Seitz HK, Stickel F. 2007. Alcoholic liver disease in the elderly. Clin Geriatr Med 23: 905-921.
33. Sell S. 1998. Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of injury. Hepatology 27: 317-331.
34. Wells RG. 2007. Function and metabolism of collagen and other extracellular matrix proteins. In: Rodes J, Benhamou J-P, Blei A, Rizzetto M, editors. A textbook of hepatology. Massachusetts: Blackwell Publishing. p 264-273.