RNA interference-mediated vascular endothelial growth factor-C reduction suppresses malignant progression and enhances mitomycin C sensitivity of bladder cancer T24 cells

Cancer Biotherapy and Radiopharmaceuticals

Volumn 27, Issue 5, 2012, Pages 291-298

  Zhang, Hui Hui ^a   Qi, Fan ^a   Shi, Ying Rui ^b   Miao, Jian Guang ^a   Zhou, Mi ^a   He, Wei ^a   Chen, Min Feng ^a   Li, Yuan ^a   Zu, Xiong Bing ^a   Qi, Lin ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b HUNAN CANCER HOSPITAL   (China)

Author keywords

apoptosis; human bladder cancer; invasion; proliferation; RNAi; vascular endothelial growth factor C (VEGF C)

Indexed keywords

CASPASE 3; GELATINASE B; LENTIVIRUS VECTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOMYCIN C; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; RECOMBINANT VASCULOTROPIN; RECOMBINANT VASCULOTROPIN C; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DISEASE PROGRESSION; GENE THERAPY; HUMANS; MITOMYCIN; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION; URINARY BLADDER NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 84862486449     PISSN: 10849785     EISSN: 15578852     Source Type: Journal    
DOI: 10.1089/cbr.2010.0919     Document Type: Article

References (26)

1. Vieweg J, Gschwend JE, Herr HW, et al. Pelvic lymph node dissection can be curative in patients with node positive bladder cancer. J Urol 1999;61:449.
2. Kukk E, Lymboussaki A, Taira S, et al. VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development 1996;122:3829.
3. Duff S, Li C, Jeziorska M, et al. Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy. Br J Cancer 2003;89:426.
4. Suzuki K, Morita T, Tokue A. Vascular endothelial growth factor-C (VEGF-C) expression predicts lymph node metastasis of transitional cell carcinoma of the bladder. Int J Urol 2005;12:152.
5. Kimura Y, Watanabe M, Ohga T, et al. Vascular endothelial growth factor C expression correlates with lymphatic involvement and poor prognosis in patients with esophageal squamous cell carcinoma. Oncol Rep 2003;10:1747.
6. Zu XB, Tang ZY, Li Y, et al. Vascular endothelial growth factor-C expression in bladder transitional cell cancer and its relationship to lymph node metastasis. BJU Int 2006;98:1090.
7. Dias S, Choy M, Alitalo K, et al. Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood 2002;99:2179.
8. He XW, Yu X, Liu T, et al. Vector-based RNA interference against vascular endothelial growth factor-C inhibits tumor lymphangiogenesis and growth of colorectal cancer in vivo in mice. Chin Med J (Engl) 2008;121:439.
9. Guo B, Zhang Y, Luo G, et al. Lentivirus-mediated small interfering RNA targeting VEGF-C inhibited tumor lymphangiogenesis and growth in breast carcinoma. Anat Rec (Hoboken) 2009;292:633.
10. Su JL, Yang PC, Shih JY, et al. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 2006;9:209.
11. Sun P, Gao J, Liu YL, et al. RNA interference (RNAi)-mediated vascular endothelial growth factor-C (VEGF-C) reduction interferes with lymphangiogenesis and enhances epirubicin sensitivity of breast cancer cells. Mol Cell Biochem 2008;308:161.
12. Krajewski S, Krajewska M, Shabaik A, et al. Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol 1994;145:1323.
13. Liu C, Wu X, Luo C, et al. Antisense oligonucleotide targeting Livin induces apoptosis of human bladder cancer cell via a mechanism involving caspase 3. J Exp Clin Cancer Res 2010;29:63.
14. Bock JM, Sinclair LL, Bedford NS, et al. Modulation of cellular invasion by VEGF-C expression in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 2008;134:355.
15. Issa A, Le TX, Shoushtari AN, et al. Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype. Cancer Res 2009;69:349.
16. Liotta LA, Stetler-Stevenson WG. Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res 1991;51:5054.
17. Di Carlo A, Terracciano D, Mariano A, et al. Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors. Oncol Rep 2006;15:1321.
18. Choi YD, Cho NH, Ahn HS, et al. Matrix metalloproteinase expression in the recurrence of superficial low grade bladder transitional cell carcinoma. J Urol 2007;177:1174.
19. Duffy MJ. The role of proteolytic enzymes in cancer invasion and metastasis. Clin Exp Metastasis 1992;10:145.
20. Witte D, Thomas A, Ali N, et al. Expression of the vascular endothelial growth factor receptor-3 (VEGFR-3) and its ligand VEGF-C in human colorectal adenocarcinoma. Anticancer Res 2002;22:1463.
21. Ma C, Lin H, Leonard SS, et al. Overexpression of ErbB2 enhances ethanol-stimulated intracellular signaling and invasion of human mammary epithelial and breast cancer cells in vitro. Oncogene 2003;22:5281.
22. Steeg PS. Metastasis suppressors alter the signal transduction of cancer cells. Nat Rev Cancer 2003;3:55.
23. Hemmings BA. Akt signaling:linking membrane events to life and death decisions. Science 1997;275:628.
24. Kennedy SG, Kandel ES, Cross TK, et al. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol Cell Biol 1999;19:5800.
25. Maddika S, Ande SR, Panigrahi S, et al. Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy. Drug Resist Update 2007;10:13.
26. Wang YB, Qin J, Zheng XY, et al. Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells. Phytomedicine 2010;17:363.