Multi high-throughput approach for highly selective identification of vaccine candidates: The group a streptococcus case

Molecular and Cellular Proteomics

Volumn 11, Issue 6, 2012, Pages

  Bensi, Giuliano ^a   Mora, Marirosa ^a   Tuscano, Giovanna ^a   Biagini, Massimiliano ^a   Chiarot, Emiliano ^a   Bombaci, Mauro ^a,c   Capo, Sabrina ^a,d   Falugi, Fabiana ^a   Manetti, Andrea G O ^a   Donato, Paolo ^a   Swennen, Erwin ^a   Gallotta, Marilena ^a,e   Garibaldi, Manuela ^a   Pinto, Vittoria ^a   Chiappini, Nico ^a   Musser, James M ^b   Janulczyk, Robert ^a   Mariani, Massimo ^a   Scarselli, Maria ^a   Telford, John L ^a   Grifantini, Renata ^a,f   Norais, Nathalie ^a   Margarit, Immaculada ^a   Grandi, Guido ^a   more..

^a NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^b HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^c Istituto Nazionale di Genetica Molecolare   (Italy)

^d USL 7   (Italy)

^e KAROLINSKA INSTITUTE   (Sweden)

^f Externautics SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; STREPTOCOCCUS ANTIGEN; STREPTOCOCCUS VACCINE; BACTERIAL ANTIGEN; BACTERIAL VACCINE; BACTERIUM ANTIBODY; OUTER MEMBRANE PROTEIN; PROTEOME;

ARTICLE; BIOINFORMATICS; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; IMMUNOGENICITY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN MICROARRAY; PROTEOMICS; STREPTOCOCCUS GROUP A; ANIMAL; BLOOD; CLUSTER ANALYSIS; FEMALE; GENETICS; HEMOLYSIS; HUMAN; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MOUSE; PHARYNGITIS; SECRETION (PROCESS); SHEEP; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PYOGENES; VACCINATION;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL VACCINES; CLUSTER ANALYSIS; FEMALE; FLOW CYTOMETRY; HEMOLYSIS; HUMANS; MICE; PHARYNGITIS; PROTEIN ARRAY ANALYSIS; PROTEOME; SHEEP; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; VACCINATION;

EID: 84862330001     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M111.015693     Document Type: Article

References (35)

1. Maione, D., Margarit, I., Rinaudo, C. D., Masignani, V., Mora, M., Scarselli, M., Tettelin, H., Brettoni, C., Iacobini, E. T., Rosini, R., D'Agostino, N., Miorin, L., Buccato, S., Mariani, M., Galli, G., Nogarotto, R., Dei, V. N., Vegni, F., Fraser, C., Mancuso, G., Teti, G., Madoff, L. C., Paoletti, L. C., Rappuoli, R., Kasper, D. L., Telford, J. L., and Grandi, G. (2005) Identification of a universal group B streptococcus vaccine by multiple genome screen. Science 309, 148-150
2. Pizza, M., Scarlato, V., Masignani, V., Giuliani, M. M., Arico, B., Comanducci, M., Jennings, G. T., Baldi, L., Bartolini, E., Capecchi, B., Galeotti, C. L., Luzzi, E., Manetti, R., Marchetti, E., Mora, M., Nuti, S., Ratti, G., Santini, L., Savino, S., Scarselli, M., Storni, E., Zuo, P., Broeker, M., Hundt, E., Knapp, B., Blair, E., Mason, T., Tettelin, H., eacute, Hood, D. W., Jeffries, A. C., Saunders, N. J., Granoff, D. M., Venter, J. C., Moxon, E. R., Grandi, G., and Rappuoli, R. (2000) Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science 287, 1816-1820
3. Grandi, G. (2010) Bacterial surface proteins and vaccines. Biol. Reports 2, 36-39
4. Doro, F., Liberatori, S., Rodriguez-Ortega, M. J., Rinaudo, C. D., Rosini, R., Mora, M., Scarselli, M., Altindis, E., D'Aurizio, R., Stella, M., Margarit, I., Maione, D., Telford, J. L., Norais, N., and Grandi, G. (2009) Surfome analysis as a fast track to vaccine discovery: identification of a novel protective antigen for group B streptococcus hypervirulent strain COH1. Mol. Cell. Proteomics 8, 1728-1737
5. Rodriguez-Ortega, M. J., Norais, N., Bensi, G., Liberatori, S., Capo, S., Mora, M., Scarselli, M., Doro, F., Ferrari, G., Garaguso, I., Maggi, T., Neumann, A., Covre, A., Telford, J. L., and Grandi, G. (2006) Characterization and identification of vaccine candidate proteins through analysis of the group A streptococcus surface proteome. Nat. Biotechnol. 24, 191-197
6. Berlanda Scorza, F., Doro, F., Rodriguez-Ortega, M. J., Stella, M., Liberatori, S., Taddei, A. R., Serino, L., Gomes Moriel, D., Nesta, B., Fontana, M. R., Spagnuolo, A., Pizza, M., Norais, N., and Grandi, G. (2008) Proteomics characterization of outer membrane vesicles from the extraintestinal pathogenic Escherichia coli delta tolR IHE3034 mutant. Mol. Cell. Proteomics 7, 473-485
7. Ferrari, G., Garaguso, I., Adu-Bobie, J., Doro, F., Taddei, A. R., Biolchi, A., Brunelli, B., Giuliani, M. M., Pizza, M., Norais, N., and Grandi, G. (2006) Outer membrane vesicles from group B Neisseria meningitidis delta gna33 mutant: proteomic and immunological comparison with detergent-derived outer membrane vesicles. Proteomics 6, 1856-1866
8. Cunningham, M. W. (2000) Pathogenesis of group A streptococcal infections. Clin. Microbiol. Rev. 13, 470-511
9. Steer, A. C., Batzloff, M. R., Mulholland, K., and Carapetis, J. R. (2009) Group A streptococcal vaccines: facts versus fantasy. Current Opinion Infectious Dis. 22, 544-552
10. Dale, J. B., Penfound, T., Chiang, E. Y., Long, V., Shulman, S. T., and Beall, B. (2005) Multivalent group A streptococcal vaccine elicits bactericidal antibodies against variant M subtypes. Clin. Diagn. Lab. Immunol. 12, 833-836
11. Dale, J. B. (2008) Current status of group A streptococcal vaccine development. Hot Topics Infection Immunity in Children IV, pp. 53-63
12. Cunningham, M. W. (2008) Pathogenesis of group A streptococcal infections and their sequelae. Hot Topics in Infection and Immunity in Children IV, pp. 29-42
13. Bombaci, M., Grifantini, R., Mora, M., Reguzzi, V., Petracca, R., Meoni, E., Balloni, S., Zingaretti, C., Falugi, F., Manetti, A. G. O., Margarit, I., Musser, J. M., Cardona, F., Orefici, G., Grandi, G., and Bensi, G. (2009) Protein array profiling of tic patient sera reveals a broad range and enhanced immune response against group A Streptococcus antigens. PLoS ONE 4, p.e6332
14. Mickelson, M. N. (1964) Chemically defined medium for growth of Streptococcus pyogenes. J. Bacteriol. 88, 158-164
15. Barinov, A., Loux, V., Hammani, A., Nicolas, P., Langella, P., Ehrlich, D., Maguin, E., and van de Guchte, M. (2009) Prediction of surface exposed proteins in Streptococcus pyogenes, with a potential application to other Gram-positive bacteria. Proteomics 9, 61-73
16. Dallo, S. F., Kannan, T. R., Blaylock, M. W., and Baseman, J. B. (2002) Elongation factor Tu and E1 β subunit of pyruvate dehydrogenase complex act as fibronectin binding proteins in Mycoplasma pneumoniae. Mol. Microbiol. 46, 1041-1051
17. Jin, H., Agarwal, S., and Pancholi, V. (2011) Surface export of GAPDH/SDH, a glycolytic enzyme, is essential for Streptococcus pyogenes virulence. MBio 2, e00068-00011
18. Ling, E., Feldman, G., Portnoi, M., Dagan, R., Overweg, K., Mulholland, F., Chalifa-Caspi, V., Wells, J., and Mizrachi-Nebenzahl, Y. (2004) Glycolytic enzymes associated with the cell surface of Streptococcus pneumoniae are antigenic in humans and elicit protective immune responses in the mouse. Clin. Exp. Immunol. 138, 290-298
19. Niewes, W., Heang, J., Asakrah, S., Honer zu Bentrup, K., Roy, C. J., and Morici, L. A. (2010) Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization. PLos One 5, p.e14361
20. Oliveira, S. C., and Splitter, G. A. (1996) Immunization of mice with recombinant L7/L12 ribosomal protein confers protection against Brucella abortus infection. Vaccine 14, 959-962
21. Yang, X., Walters, N., Robison, A., Trunkle, T., and Pascual, D. W. (2007) Nasal immunization with recombinant Brucella melitensis bp26 and trigger factor with cholera toxin reduces B. melitensis colonization. Vaccine 25, 2261-2268
22. Ji, Y., Carlson, B., Kondagunta, A., and Cleary, P. P. (1997) Intranasal immunization with C5a peptidase prevents nasopharyngeal colonization of mice by the group A Streptococcus. Infect. Immun. 65, 2080-2087
23. Shet, A., K. E., Johnson, D., and Cleary, P. P. (2004) Human immunogenicity studies on group A streptococcal C5a peptidase (SCPA) as a potential vaccine against group A streptococcal infections. Indian J. Med. Res. 119,
24. Edwards, R. J., Taylor, Graham W., Ferguson, M., Murray, S., Rendell, N., Wrigley, A., Bai, Z., Boyle, J., Finney, Simon J., Jones, A., Russell, Hugh H., Turner, C., Cohen, J., Faulkner, L., and Sriskandan, S. (2005) Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes. J. Inf. Dis. 192, 783-790
25. Zinkernagel, A. S., Timmer, A. M., Pence, M. A., Locke, J. B., Buchanan, J. T., Turner, C. E., Mishalian, I., Sriskandan, S., Hanski, E., and Nizet, V. (2008) The IL-8 protease SpyCEP/ScpC of group A streptococcus promotes resistance to neutrophil killing. Cell Host Microbe 4, 170-178
26. Mora, M., Veggi, D., Santini, L., Pizza, M., and Rappuoli, R. (2003) Reverse vaccinology. Drug Discovery Today 8, 459-464
27. Meinke, A., Henics, T., Hanner, M., Minh, D. B., and Nagy, E. (2005) Antigenome technology: a novel approach for the selection of bacterial vaccine candidate antigens. Vaccine 23, 2035-2041
28. Fritzer, A., Senn, B. M., Minh, D. B., Hanner, M., Gelbmann, D., Noiges, B., Henics, T., Schulze, K., Guzman, C. A., Goodacre, J., von Gabain, A., Nagy, E., and Meinke, A. L. (2010) Novel conserved group A streptococcal proteins identified by the antigenome technology as vaccine candidates for a non-M protein-based vaccine. Infect. Immun. 78, 4051-4067
29. Grandi, G. (2005) Genomics and proteomics in reverse vaccines. Microbial Proteomics, pp. 379-393, John Wiley & Sons, Inc.
30. McNeil, S. A., Halperin, S. A., Langley, J. M., Smith, B., Warren, A., Sharratt, G. P., Baxendale, D. M., Reddish, M. A., Hu, M. C., Stroop, S. D., Linden, J., Fries, L. F., Vink, P. E., and Dale, J. B. (2005) Safety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adult volunteers. Clin. Inf. Dis. 41, 1114-1122
31. Lancefield, R. C. (1957) Differentiation of group A streptococci with a common R antigen into three serological types, with special reference to the bactericidal test. J. Exp. Med. 106, 525-544
32. Lancefield, R. C. (1959) Persistence of type-specific antibodies in man following infection with group A streptococci. J. Exp. Med. 110, 271-292
33. Lancefield, R. C. (1962) Current knowledge of type-specific M antigens of group A streptococci. J. Immunol. 89, 307-313
34. Sumby, P., Zhang, S., Whitney, A. R., Falugi, F., Grandi, G., Graviss, E. A., DeLeo, F. R., and Musser, J. M. (2008) A chemokine-degrading extracellular protease made by group A streptococcus alters pathogenesis by enhancing evasion of the innate immune response. Infect. Immun. 76, 978-985
35. Alouf, J. E. (1980) Streptococcal toxins (streptolysin O, streptolysin S, erythrogenic toxin). Pharmac. Ther. 11, 661-717