Association of IL-4 receptor gene polymorphisms with high density lipoprotein cholesterol

Cytokine

Volumn 59, Issue 2, 2012, Pages 309-312

  Chang, Yih Hsin ^a   Huang, Chien Ning ^b,c   Shiau, Ming Yuh ^d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

High density lipoprotein cholesterol; Interleukin 4; Interleukin 4 receptor; Lipid metabolism

Indexed keywords

CREATININE; GENOMIC DNA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 4 RECEPTOR ALPHA; TRIACYLGLYCEROL; UREA;

ADULT; ALLELE; ARTICLE; ASIAN; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DNA EXTRACTION; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; IL 4 RECEPTOR ALPHA GENE; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR GENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TAIWANESE; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL;

CASE-CONTROL STUDIES; CHOLESTEROL, HDL; DEMOGRAPHY; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84862317307     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.04.023     Document Type: Article

References (37)

1. Cathcart M.K., Morel D.W., Chisolm G.M. Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic. J Leukocyte Biol 1985, 38:341-350.
2. Quinn M.T., Parthasarathy S., Fong L.G., Steinberg D. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA 1987, 84:2995-2998.
3. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., Witztum J.L. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989, 320:915-924.
4. Frostegård J., Nilsson J., Haegerstrand A., Hamsten A., Wigzell H., Gidlund M. Oxidized low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U937. Proc Natl Acad Sci USA 1990, 87:904-908.
5. Witztum J.L., Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest 1991, 88:1785-1792.
6. Kume N., Cybulsky M.I., Gimbrone M.A. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest 1992, 90:1138-1144.
7. Terkeltaub R., Banka C.L., Solan J., Santoro D., Brand K., Curtiss L.K. Oxidized LDL induces monocytic cell expression of interleukin-8, a chemokine with T-lymphocyte chemotactic activity. Arterioscler Thromb 1994, 14:47-53.
8. Zhou X., Paulsson G., Stemme S., Hansson G.K. Hypercholesterolemia is associated with a T Helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice. J Clin Invest 1998, 101:1717-1725.
9. Stemme S., Faber B., Holm J., Wiklund O., Witztum J.L., Hansson G.K. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc Natl Acad Sci USA 1995, 92:3893-3897.
10. Zurawski G., de Vries J.E. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 1994, 15:19-26.
11. Garcia-Zepeda E.A., Combadiere C., Rothenberg M.E., et al. Human monocyte chemoattractant protein-4 is a novel CC chemokine with activates on macrophage, eosinophils, and basophils induced in allergic and non-allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol 1996, 157:5613-5626.
12. Paul W.E. Interleukin 4: signaling mechanisms and control of T cell differentiation. Ciba Found Symp 1997, 204:208-216.
13. Takeda K., Kishimoto T., Akira S. STAT6: its role in interleukin 4-mediated biological functions. J Mol Med 1997, 75:317-326.
14. Pritchard M.A., Baker E., Whitmore S.A., et al. The interleukin-4 receptor gene in the context of diseases linked to the IL4 pathway. (IL4R) maps to 16p11.2-16p12.1 in the human and to the distal region of mouse chromosome 7. Genomics 1991, 10:801-806.
15. Russell S.M., Keegan A.D., Harada N., et al. The interleukin-2 receptor γ chain is a functional component of the interleukin-4 receptor. Science 1993, 262:1880-1883.
16. Idzerda R.L., March C.J., Mosley B., et al. Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med 1990, 171:861-873.
17. Chaitidis P., O'Donnell V., Kuban R.J., Bermudez-Fajardo A., Ungethuem U., Kuhn H. Gene expression alternations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13. Cytokine 2005, 30:366-377.
18. Deichmann K., Bardutzky J., Forster J., Heinzmann A., Kuehr J. Common polymorphisms in the coding part of the IL4-receptor gene. Biochem Biophys Res Commun 1997, 231:696-697.
19. Hershey G.K.K., Friedrich M.F., Esswein L.A., Thomas M.L., Chatila T.A. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Eng J Med 1997, 337:1720-1725.
20. Kruse S., Japha T., Tedner M., et al. The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction. Immunology 1999, 96:365-371.
21. Ober C., Cleavitt S.A., Tsalenko A., et al. Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. Am J Hum Genet 2000, 66:517-526.
22. Hackstein H., Hecker M., Kruse S., et al. A novel polymorphism in the 5' promoter region of the human interleukin-4 receptor alpha-chain gene is associated with decreased soluble interleukin-4 receptor protein levels. Immunogenetics 2001, 53:264-269.
23. Shirakawa I., Deichmann K.A., Izuhara I., Mao I., Adra C.N., Hopkin J.M. Atopy and asthma: genetic variants of IL-4 and IL-13 signalling. Immunol Today 2000, 21:60-64.
24. Erlich H.A., Lohman K., Mack S.J., et al. Association analysis of SNPs in the IL4R locus with type I diabetes. Genes Immun 2009, 10(Suppl. 1):S33-S41.
25. Wang M., Wang S., Song Z., Ji X., Zhang Z., Zhou J., et al. Associations of IL-4, IL-4R, and IL-13 gene polymorphisms in coal workers' pneumoconiosis in China: a case-control study. PLoS One 2011, 6:e22624.
26. Cornicelli J.A., Butteiger D., Rateri D.L., Welch K., Daugherty A. Interleukin-4 augments acetylated LDL-induced cholesterol esterification in macrophages. J Lipid Res 2000, 41:376-383.
27. Conrad D.J., Kuhn H., Mulkins M., Highland E., Sigal E. Specific inflammatory cytokines regulate the expression of human monocyte 15-LO. Proc Natl Acad Sci USA 1992, 89:217-221.
28. Cornicelli J.A., Welch K., Auerbach B., Feinmark S.J., Daugherty A. Mouse peritoneal macrophages contain abundant v-6 lipoxygenase activity that is independent of interleukin-4. Arterioscler Thromb Vasc Biol 1996, 16:1488-1494.
29. Georas S., Cumberland J., Burke T., Park E., Ono S., Casolaro V. Characterization of a novel negative regulatory element in the human interleukin 4 promoter. Leukemia 2000, 14:629-635.
30. Hall I.P. Interleukin-4 receptor a gene variants and allergic disease. Respir Res 2000, 1:6-8.
31. Izuhara K., Shirakawa T. Signal transduction via the interleukin-4 receptor and its correlation with atopy. Int J Mol Med 1999, 3:3-10.
32. Marsh D.G., Neely J.D., Breazeale D.R., et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994, 1152-1156.
33. Rosenwasser L.J., Klemm D.J., Dresback J.K., et al. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995, 25(Suppl. 2):74-78.
34. Song Z., Casolaro V., Chen R., Georas S.N., Monos D., Ono S.J. Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene. J Immunol 1996, 156:424-429.
35. George J., Mulkins M., Shais A., et al. Interleukin (IL)-4 deficiency does not influence fatty streak formation in C57BL:6 mice. Atherosclerosis 2000, 153:403-411.
36. Ho K.T., Shiau M.Y., Chang Y.H., Chen C.M., Yang S.C., Huang C.N. Association of IL-4 promoter polymorphisms in Taiwanese patients with type 2 diabetes mellitus. Metabolism 2010, 59:1717-1722.
37. Chang YH, Ho KT, Lu SH, Huang CN, Shiau MY. Regulation of glucose/lipid metabolism and insulin sensitivity by interleukin-4. Int J Obesity 2012, in press. http://dx.doi.org/10.1038/ijo.2011.168. http://dx.doi.org/10.1038/ijo.2011.168.