Tempol suppresses micronuclei formation in astrocytes of newborn rats exposed to 50-Hz, 10-mT electromagnetic fields under bleomycin administration

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 747, Issue 1, 2012, Pages 138-141

  Miyakoshi, Yuichi ^a   Kajihara, Chieko ^a   Shimizu, Hidesuke ^a   Yanagisawa, Hiroyuki ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Active oxygen species; Bleomycin; Electromagnetic fields; Micronucleus test; Tempol

Indexed keywords

BLEOMYCIN; GLIAL FIBRILLARY ACIDIC PROTEIN; TEMPOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; DRUG EFFECT; ELECTROMAGNETIC FIELD; MALE; MICRONUCLEUS TEST; MUTAGENESIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; ANTIBIOTICS, ANTINEOPLASTIC; ASTROCYTES; BLEOMYCIN; BRAIN; CELLS, CULTURED; CYCLIC N-OXIDES; ELECTROMAGNETIC FIELDS; MALE; MICRONUCLEUS TESTS; MUTAGENS; RADIATION-PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SPIN LABELS;

RATTUS;

EID: 84862308244     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2012.05.001     Document Type: Article

References (36)

1. Wertheimer N., Leeper E.D. Electrical wiring configurations and childhood cancer. Am. J. Epidemiol. 1979, 109:273-284.
2. Miller R.D., Neuberger J.S., Gerald K.B. Brain cancer and leukemia and exposure to power-frequency (50- to 60-Hz) electric and magnetic fields. Epidemiol. Rev. 1997, 19:273-293.
3. Kabuto M., Nitta H., Yamamoto S., Yamaguchi N., Akiba S., Honda Y., Hagihara J., Isaka K., Saito T., Ojima T., Nakamura Y., Mizoue T., Ito S., Eboshida A., Yamazaki S., Sokejima S., Kurokawa Y., Kubo O. Childhood leukemia and magnetic field in Japan: a case-control study of childhood leukemia and residential power-frequency magnetic fields in Japan. Int. J. Cancer 2006, 119:643-650.
4. Kheifets L., Monroe J., Vergara X., Mezei G., Afifi A.A. Occupational electromagnetic fields and leukemia and brain cancer: an update to two meta-analysis. J. Occup. Environ. Med. 2008, 50:677-688.
5. Saito T., Nitta H., Kubo O., Yamamoto S., Yamaguchi N., Akiba S., Honda Y., Hagihara J., Isaka K., Ojima T., Nakamura Y., Mizoue T., Ito S., Eboshida A., Yamazaki S., Sokejima S., Kurokawa Y., Kabuto M. Power-frequency magnetic fields and childhood brain tumors: a case-control study in Japan. J. Epidemiol. 2010, 20:54-61.
6. McCann J., Dietrich F., Raffery C., Martin A. A critical review of the genotoxic potential of electric and magnetic fields. Mutat. Res. 1993, 297:61-95.
7. McCann J., Dietrich F., Raffery C. The genotoxic potential of electric and magnetic fields: an update. Mutat. Res. 1998, 411:45-86.
8. Simko M. Cell type specific redox status is responsible for diverse electromagnetic field effects. Curr. Med. Chem. 2007, 14:1141-1152.
9. Heddle L.A., Hite M., Kierkhart B., Mavourin K., MacGregor J.T., Newell G.W., Salamone M.F. The induction of micronuclei as a measure of genotoxicity, a report of the US Environmental Protection Agency Gene-Tox Program. Mutat. Res. 1983, 123:61-118.
10. Burger R.M. Cleavage of nucleic acids by bleomycin. Chem. Rev. 1998, 98:1153-1169.
11. Miyakoshi Y., Suzuki Y., Ooida M., Takahashi A., Tsukui M. Micronucleus test using cultured new born rat astrocytes. Ind. Health 1999, 37:95-102.
12. Cho Y.H., Jeon H.K., Chung H.W. Effects of extremely low-frequency electromagnetic fields on delayed chromosomal instability induced by bleomycin in normal human fibroblast cells. J. Toxicol. Environ. Health Part A 2007, 70:1252-1258.
13. Watanabe Y., Nakagawa M., Miyakoshi Y. Enhancement of lipid peroxidation in the liver of mice exposed to magnetic fields. Ind. Health 1997, 35:285-290.
14. Chatterjee P.K., Cuzzocrea S., Brown P.A.J., Zacharowski K., Stewart K.N., Mota-Filipe H., Thiemermann C. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int. 2000, 58:658-673.
15. Toga W., Suzuki Y., Shimizu H. In vivo micronuclei test in rat newborn astrocytes. Mutat. Res. 2001, 483(Suppl. 1):S162.
16. Suzuki Y., Shimizu H., Kim S.U. Induction of micronucleus in NSC19 motoneuron cell line by genotoxic chemicals. Neurotoxicology 1997, 18:325-330.
17. Kastenbaum M.A., Bowman K.O. Tables for determining the statistical significance of mutation frequencies. Mutat. Res. 1970, 9:527-549.
18. Loscher W., Mevissen M., Lehmacher W., Stamm A. Tumor promotion in a breast cancer model by exposure to a weak alternating magnetic field. Cancer Lett. 1993, 71:75-81.
19. Thun-Battersby S., Mevissen M., Loscher W. Exposure of Sprague-Dawley rats to a 50-Hertz, 100-μTesla magnetic field for 27 weeks facilitates mammary tumorgenesis in the 7, 12-dimethylbenz (a) anthracene model of breast cancer. Cancer Res. 1999, 59:3627-3633.
20. Manti L., D'Arco A. Cooperative biological effects between ionizing radiation and other physical and chemical agents. Mutat. Res. 2010, 704:115-122.
21. Mevissen M., Kietzmann M., Loscher W. In vivo exposure of rats to a weak alternating magnetic field increases ornithine decarboxylase activity in the mammary gland by a similar extent as the carcinogen DMBA. Cancer Lett. 1995, 90:207-214.
22. Adey W.R. Biological effects of electromagnetic fields. J. Cell. Biochem. 1993, 51:41-416.
23. Frey A.H. Electromagnetic field interactions with biological systems. FASEB J. 1993, 7:272-281.
24. Koifman S. Electromagnetic fields - a cancer promoter?. Med. Hypotheses 1993, 41:23-27.
25. Loscher W., Mevissen M. Animal studies on the role of 50/60 Hertz magnetic fields in carcinogenesis. Life Sci. 1994, 54:1531-1543.
26. Reiter R.J. Static and extremely low frequency electromagnetic field exposure - reported effects on the circardian production of melatonin. J. Cell. Biochem. 1993, 51:394-403.
27. Walleczek J. Electromagnetic field effects on cells of the immune system: the role of calcium signaling. FASEB J. 1992, 6:3177-3185.
28. Repacholi M.H., Greenbaum B. Interaction of static and extremely low frequency electric and magnetic fields with living systems: health effects and research needs. Bioelectromagnetics 1999, 20:133-160.
29. Stevens R.G., Davis S., Thomas D.B., Anderson L.E., Wilson B.W. Electric power, pineal function, and the risk of breast cancer. FASEB J. 1992, 6:853-860.
30. Karasek M., Lerchl A. Melatonin and magnetic fields. Neuro. Endocrinol. Lett. 2002, 23(Suppl 1):84-87.
31. Schernhammer E.S., Schulmeister K. Melatonin and cancer risk: does light at night compromise physiologic cancer protection by lowering serum melatonin levels?. Br. J. Cancer 2004, 90:941-943.
32. Loscher W., Liburdy R.P. Animal and cellular studies on carcinogenesis effects of low frequency (50/60-Hz) magnetic fields. Mutat. Res. 1998, 410:185-220.
33. Phillip J.L. Effects of electromagnetic field exposure on gene transcription. J. Cell. Biochem. 1993, 51:381-386.
34. Lin H., Bland M., Rossol-Haseroth K., Goodman R. Regulating genes with electromagnetic response elements. J. Cell. Biochem. 2001, 81:143-148.
35. Marcu K.B., Bossome S.A., Patel A.J. MYC function and regulation. Annu. Rev. Biochem. 1992, 61:809-860.
36. Brescia F., Sarti M., Massa R., Calabrese M.L., Sannino A., Scarfi M.R. Reactive oxygen species formation is not enhanced by exposure to UMTS 1950MHz radiation and co-exposure to ferrous ions in Jurkat cells. Bioelectromagnetics 2009, 30:525-535.