Obesity-independent association of human adenovirus ad37 seropositivity with nonalcoholic fatty liver disease

Journal of Clinical Gastroenterology

Volumn 46, Issue 6, 2012, Pages e46-e54

  Trovato, Guglielmo M ^a   Martines, Giuseppe Fabio ^a   Pirri, Clara ^a   Trovato, Francesca M ^a   Castro, Angelo ^a   Garozzo, Adriana ^a   Catalano, Daniela ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Adenovirus Ad37; Bright liver; Fatty liver; HOMA; Insulin resistance; Liver steatosis; Mediterranean diet; NAFLD; Obesity

Indexed keywords

C REACTIVE PROTEIN;

ADULT; ARTICLE; BODY MASS; CALORIC INTAKE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN ADENOVIRUS; HUMAN ADENOVIRUS 37; HUMAN ADENOVIRUS INFECTION; HUMAN CELL; INSULIN RESISTANCE; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MEDITERRANEAN DIET; MULTIPLE LINEAR REGRESSION ANALYSIS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PATIENT COUNSELING; PHYSICAL ACTIVITY; PREVALENCE; PRIORITY JOURNAL; RISK; SEROLOGY; ULTRASOUND BRIGHT LIVER SCORE; VARIANCE;

ADENOVIRUS INFECTIONS, HUMAN; ADENOVIRUSES, HUMAN; ADULT; BODY MASS INDEX; C-REACTIVE PROTEIN; DIET, MEDITERRANEAN; FATTY LIVER; FEMALE; HUMANS; INSULIN RESISTANCE; LIFE STYLE; LINEAR MODELS; MALE; MIDDLE AGED; MOTOR ACTIVITY; OBESITY; PREVALENCE; SEVERITY OF ILLNESS INDEX; SMOKING CESSATION;

EID: 84862302418     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0b013e31824b225c     Document Type: Article

References (51)

1. O’Rahilly S, Farooqi IS. Human obesity as a heritable disorder of the central control of energy balance. Int J Obes (Lond). 2008;32(suppl 7):S55-S61
2. Levin BE. Synergy of nature and nurture in the development of childhood obesity. Int J Obes (Lond). 2009;33(suppl 1):S53-S56
3. Robinson SM, Godfrey KM. Feeding practices in pregnancy and infancy: relationship with the development of overweight and obesity in childhood. Int J Obes (Lond). 2009;32(suppl 6):S4-10
4. Leskinen T, Sipilä S, Alen M, et al. Leisure-time physical activity and high-risk fat: a longitudinal population-based twin study. Int J Obes (Lond). 2009;33:1211-1218
5. Sherry B. Food behaviors and other strategies to prevent and treat pediatric overweight. Int J Obes (Lond). 2005;29(suppl 2):S116-S126
6. Mustelin L, Silventoinen K, Pietiläinen K, et al. Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins. Int J Obes (Lond). 2009;33:29-36
7. Robinson SM, Godfrey KM. Feeding practices in pregnancy and infancy: relationship with the development of overweight and obesity in childhood. Int J Obes (Lond). 2008;32(suppl 6):S4-10
8. Lin G, Spann S, Hyman D, et al. Climate amenity and BMI. Obesity (Silver Spring). 2007;15:2120-2127
9. Cohen DA. Obesity and the built environment: changes in environmental cues cause energy imbalances. Int J Obes (Lond). 2008;32(suppl 7):S137-S142
10. Grafova IB, Freedman VA, Kumar R, et al. Neighborhoods and obesity in later life. Am J Public Health. 2008;98:2065-2071
11. Due P, Damsgaard MT, Rasmussen M, et al. Socioeconomic position, macroeconomic environment and overweight among adolescents in 35 countries. Int J Obes (Lond). 2009;33:1084-1093
12. Floch MH. The effect of probiotics on host metabolism: the microbiota and fermentation. J Clin Gastroenterol. 2010;44(suppl 1):S19-S21
13. Mitra AK, Clarke K. Viral obesity: fact or fiction? Obes Rev. 2010;11:289-296
14. Whigham LD, Israel BA, Atkinson RL. Adipogenic potential of multiple human adenoviruses in vivo and in vitro in animals. Am J Physiol Regul Integr Comp Physiol. 2006;290:R190-R194
15. Yki-Järvinen H. Fat in the liver and insulin resistance. Ann Med. 2005;37:347-356
16. Jacobs M, van Greevenbroek MM, van der Kallen CJ, et al. The association between the metabolic syndrome and alanine amino transferase is mediated by insulin resistance via related metabolic intermediates (the Cohort on Diabetes and Atherosclerosis Maastricht [CODAM] study). Metabolism. 2011;60:969-975
17. Suplicy Hde L, Bornschein A. Infections as the etiology for obesity. Arq Bras Endocrinol Metabol. 2009;53:159-164
18. van Ginneken V, Sitnyakowsky L, Jeffery JE. “Infectobesity: viral infections (especially with human adenovirus-36: Ad-36) may be a cause of obesity. Med Hypotheses. 2009;72:383-388
19. Trovato GM, Castro A, Tonzuso A, et al. Human obesity relationship with Ad-36 adenovirus and insulin resistance. Int J Obes (Lond). 2009;33:1402-1409
20. Trovato GM, Martines GF, Garozzo A, et al. Ad-36 adipogenic adenovirus in human non-alcoholic fatty liver disease. Liver Int. 2010;30:184-190
21. Na HN, Hong YM, Kim J, et al. Association between human adenovirus-36 and lipid disorders in Korean schoolchildren. Int J Obes (Lond). 2010;34:89-93
22. Broderick MP, Hansen CJ, Irvine M, et al. Adenovirus 36 seropositivity is strongly associated with race and gender, but not obesity, among US military personnel. Int J Obes (Lond). 2010;34:302-308
23. Patel AA, Torres DM, Harrison SA. Effect of weight loss on nonalcoholic fatty liver disease. J Clin Gastroenterol. 2009;43:970-974
24. Catalano D, Trovato GM, Martines GF, et al. Bright liver, body composition and insulin resistance changes with nutritional intervention: a follow-up study. Liver Int. 2008;28:1280-1287
25. Mathiesen UL, Franzén LE, Aselius H, et al. Increased liver echogenicity at ultrasound examination reflects degree of steatosis but not of fibrosis in asymptomatic patients with mild/moderate abnormalities of liver transaminases. Dig Liver Dis. 2002;34:516-522
26. Ratziu V, Charlotte F, Heurtier A, et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology. 2005;128:1898-1906
27. Saadeh S, Younossi ZM, Remer EM, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002;123:745-750
28. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419
29. Trovato GM, Catalano D, Caruso G, et al. Relationship between cardiac function and insulin resistance in obese patients. Diabetes Nutr Metab. 2001;14:325-328
30. Riquelme A, Arrese M, Soza A, et al. Non-alcoholic fatty liver disease and its association with obesity, insulin resistance and increased serum levels of C-reactive protein in Hispanics. Liver Int. 2009;29:82-88
31. Malik R, Chang M, Bhaskar K, et al. The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN liver biopsy scoring system in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2009;24:564-568
32. Clark JM. Weight loss as a treatment for nonalcoholic fatty liver disease. J Clin Gastroenterol. 2006;40(Suppl 1):S39-S43
33. De Bruyne RM, Fitzpatrick E, Dhawan A. Fatty liver disease in children: eat now pay later. Hepatol Int. 2010;4:375-385
34. Yamashiki N, Sugawara Y, Tamura S, et al. Noninvasive estimation of hepatic steatosis in living liver donors: usefulness of visceral fat area measurement. Transplantation. 2009;88:575-581
35. Rothenberg M, Cheung R, Ahmed A. Adenovirus-induced acute liver failure. Dig Dis Sci. 2009;54:218-221
36. Trichopoulou A, Costacou T, Bamia C, et al. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003;348:2599-2608
37. Palmentieri B, de Sio I, La Mura V, et al. The role of bright liver echo pattern on ultrasound B-mode examination in the diagnosis of liver steatosis. Dig Liver Dis. 2006;38:485-489
38. Abonyo BO, Alexander MS, Heiman AS. Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2005;289:L478-L488
39. Atkinson RL, Dhurandhar NV, Allison DB, et al. Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. Int J Obes (Lond). 2005;29:281-286
40. Negro F, Sanyal AJ. Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data. Liver Int. 2009;29(suppl 2):26-37
41. Younossi ZM, McCullough AJ, Ong JP, et al. Obesity and non-alcoholic fatty liver disease in chronic hepatitis C. J Clin Gastroenterol. 2004;38:705-709
42. Rathod M, Vangipuram SD, Krishnan B, et al. Viral mRNA expression but not DNA replication is required for lipogenic effect of human adenovirus Ad-36 in preadipocytes. Int J Obes (Lond). 2007;31:78-86
43. Vangipuram SD, Yu M, Tian J, et al. Adipogenic human adenovirus-36 reduces leptin expression and secretion and increases glucose uptake by fat cells. Int J Obes (Lond). 2007;31:87-96
44. Waye MM. New insights into how adenovirus might lead to obesity: An oxidative stress theory. Free Radic Res. 2011;45:880-887
45. Miele L, Valenza V, La Torre G, et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology. 2009;49:1877-1887
46. Guttman JA, Finlay BB. Tight junctions as targets of infectious agents. Biochim Biophys Acta. 2009;1788:832-841
47. Gonzalez-Mariscal L, Garay E, Lechuga S. Virus interaction with the apical junctional complex. Front Biosci. 2009;14:731-768
48. Schreuder TC, Marsman HA, Lenicek M, et al. The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance. Am J Physiol Gastrointest Liver Physiol. 2010;298:G440-G445
49. Vijay-Kumar M, Aitken JD, Carvalho FA, et al. Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science. 2010;328:228-231
50. Verdam FJ, Rensen SS, Driessen A, et al. Novel evidence for chronic exposure to endotoxin in human nonalcoholic steatohepatitis. J Clin Gastroenterol. 2011;45:149-152
51. Brun P, Castagliuolo I, Di Leo V, et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2007;292:G518-25