Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: The women's health initiative memory study

International Psychogeriatrics

Volumn 24, Issue 8, 2012, Pages 1252-1264

  Goveas, Joseph S ^a   Hogan, Patricia E ^b   Kotchen, Jane M ^a   Smoller, Jordan W ^c   Denburg, Natalie L ^d   Manson, Joann E ^e   Tummala, Aruna ^a   Mysiw, W Jerry ^f   Ockene, Judith K ^g   Woods, Nancy F ^h   Espeland, Mark A ^b   Wassertheil Smoller, Sylvia ⁱ  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f OHIO STATE UNIVERSITY   (United States)

^g UNIVERSITY OF MASSACHUSETTS   (United States)

^h UNIVERSITY OF WASHINGTON   (United States)

ⁱ ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

antidepressants; cognitive decline; dementia; late life depression; mild cognitive impairment; selective serotonin reuptake inhibitors

Indexed keywords

SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

AGED; ARTICLE; CLINICAL TRIAL (TOPIC); COGNITION; COHORT ANALYSIS; DEMENTIA; DEPRESSION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FOLLOW UP; HORMONAL THERAPY; HUMAN; HUMAN EXPERIMENT; MILD COGNITIVE IMPAIRMENT; NEUROLOGIC EXAMINATION; NORMAL HUMAN; POSTMENOPAUSE; WOMEN'S HEALTH;

AGED; ANTIDEPRESSIVE AGENTS; CLIMACTERIC; COHORT STUDIES; COMORBIDITY; CROSS-SECTIONAL STUDIES; DEMENTIA; DEPRESSIVE DISORDER; ESTROGEN REPLACEMENT THERAPY; FEMALE; FOLLOW-UP STUDIES; HEALTH SURVEYS; HUMANS; INCIDENCE; MILD COGNITIVE IMPAIRMENT; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS; UNITED STATES;

EID: 84862287529     PISSN: 10416102     EISSN: 1741203X     Source Type: Journal    
DOI: 10.1017/S1041610211002778     Document Type: Article

References (35)

1. Aboukhatwa, M., Dosanjh, L. and Luo, Y. (2010). Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease. Molecular Neurodegenertion, 5, 10.
2. Alexopoulos, G. S. (2005). Depression in the elderly. Lancet, 365, 1961-1970.
3. Almeida, O. P., Alfonso, H., Hankey, G. J. and Flicker, L. (2010). Depression, antidepressant use and mortality in later life: The health in men study. PLoS One, 5, e11266.
4. Bhalla, R. K. et al. (2009). Patterns of mild cognitive impairment after treatment of depression in the elderly. American Journal of Geriatric Psychiatry, 17, 308-316.
5. Borhani, N. O. et al. (1991). Systolic Hypertension in the Elderly Program (SHEP). Part 1: Rationale and design. Hypertension, 17, II2-II15.
6. Butters, M. A. et al. (2008). Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B. Alzheimer Disease and Associated Disorders, 22, 261-268.
7. Coupland, C., Dhiman, P., Morriss, R., Arthur, A., Barton, G. and Hippisley-Cox, J. (2011). Antidepressant use and risk of adverse outcomes in older people: Population based cohort study. BMJ, 343, d4551.
8. Culang, M. E. et al. (2009). Change in cognitive functioning following acute antidepressant treatment in late-life depression. American Journal of Geriatric Psychiatry, 17, 881-888.
9. Goveas, J. S., Espeland, M. A., Woods, N. F., Wassertheil-Smoller, S. and Kotchen, J. M. (2011). Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: The Women's Health Initiative Memory Study. Journal of the American Geriatric Society, 59, 57-66.
10. Haney, E. M., Warden, S. J. and Bliziotes, M. M. (2010). Effects of selective serotonin reuptake inhibitors on bone health in adults: Time for recommendations about screening, prevention and management? Bone, 46, 13-17.
11. Hashioka, S., Mcgeer, P. L., Monji, A. and Kanba, S. (2009). Anti-inflammatory effects of antidepressants: Possibilities for preventives against Alzheimer's disease. Central Nervous System Agents in Medicinal Chemistry, 9, 12-19.
12. Irie, F., Masaki, K. H., Petrovitch, H., Abbott, R. D., Ross,G.W., Taaffe, D. R. (2008). Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: The Honolulu-Asia Aging Study. Archives of General Psychiatry, 65, 906-912.
13. Knegtering, H., Eijck, M. and Huijsman, A. (1994). Effects of antidepressants on cognitive functioning of elderly patients. A review. Drugs and Aging, 5, 192-199.
14. Lee, J. S., Potter, G. G., Wagner, H. R., Welsh-Bohmer, K. A. and Steffens, D. C. (2007). Persistent mild cognitive impairment in geriatric depression. International Psychogeriatrics, 19, 125-135.
15. Mark, T. L., Joish, V. N., Hay, J. W., Sheehan, D. V., Johnston, S. S. and Cao, Z. (2011). Antidepressant use in geriatric populations: The burden of side effects and interactions and their impact on adherence and costs. American Journal of Geriatric Psychiatry, 19, 211-221.
16. Mossello, E., Boncinelli, M., Caleri, V., Cavallini, M. C., Palermo, E., Di Bari, M. (2008). Is antidepressant treatment associated with reduced cognitive decline in Alzheimer's disease? Dementia and Geriatric Cognitive Disorders, 25, 372-379.
17. Nelson, R. L. et al. (2007). Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice. Experimental Neurology, 205, 166-176.
18. Ownby, R. L., Crocco, E., Acevedo, A., John, V. and Loewenstein, D. (2006). Depression and risk for Alzheimer disease: Systematic review, meta-Analysis, and metaregression analysis. Archives of General Psychiatry, 63, 530-538.
19. Rajji, T. K., Mulsant, B. H., Lotrich, F. E., Lokker, C. and Reynolds, C. F., III. (2008). Use of antidepressants in late-life depression. Drugs and Aging, 25, 841-853.
20. Ravaglia, G. et al. (2008). Prevalent depressive symptoms as a risk factor for conversion to mild cognitive impairment in an elderly Italian cohort. American Journal of Geriatric Psychiatry, 16, 834-843.
21. Reynolds, C. F., III. et al. (2011). Maintenance treatment of depression in old age: A randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy. Archives of General Psychiatry, 68, 51-60.
22. Santarelli, L. et al. (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science, 301, 805-809.
23. Sapolsky, R. M. (2000). Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Archives of General Psychiatry, 57, 925-935.
24. Sheline, Y. I. et al. (2010). Support for the vascular depression hypothesis in late-life depression: Results of a 2-site, prospective, antidepressant treatment trial. Archives of General Psychiatry, 67, 277-285.
25. Shumaker, S. A. et al. (1998). The Women's Health Initiative Memory Study (WHIMS): A trial of the effect of estrogen therapy in preventing and slowing the progression of dementia. Controlled Clinical Trials, 19, 604-621.
26. Shumaker, S. A. et al. (2004). Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA, 291, 2947-2958.
27. Smoller, J. W. et al. (2009). Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women's Health Initiative study. Archives of Internal Medicine, 169, 2128-2139.
28. Steffens, D. C. et al. (2000). Hippocampal volume in geriatric depression. Biological Psychiatry, 48, 301-309.
29. Steffens, D. C. et al. (2004). Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study. Journal of Geriatric Psychiatry and Neurology, 17, 202-211.
30. Steffens, D. C. et al. (2006). Perspectives on depression, mild cognitive impairment, and cognitive decline. Archives of General Psychiatry, 63, 130-138.
31. Steffens, D. C., Chung, H., Krishnan, K. R., Longstreth, W. T., Jr., Carlson, M. and Burke,G. L. (2008). Antidepressant treatment and worsening white matter on serial cranial magnetic resonance imaging in the elderly: The Cardiovascular Health Study. Stroke, 39, 857-862.
32. Tuunainen, A., Langer, R. D., Klauber, M. R. and Kripke, D. F. (2001). Short version of the CES-D (Burnam screen) for depression in reference to the structured psychiatric interview. Psychiatry Research, 103, 261-270.
33. Weintraub, D. et al. (2010). Sertraline for the treatment of depression in Alzheimer disease: Week-24 outcomes. American Journal of Geriatric Psychiatry, 18, 332-340.
34. Woolcott, J. C. et al. (2009). Meta-Analysis of the impact of 9 medication classes on falls in elderly persons. Archives of Internal Medicine, 169, 1952-1960.
35. Wright, R. M. et al. (2009). Effect of central nervous system medication use on decline in cognition in community-dwelling older adults: Findings from the Health, Aging And Body Composition Study. Journal of the American Geriatric Society, 57, 243-250.