메뉴 건너뛰기




Volumn 138, Issue 5, 2012, Pages 729-737

Tumor suppressor gene BLU is frequently downregulated by promoter hypermethylation in myelodysplastic syndrome

Author keywords

5 aza 2' deoxycytidine; BLU; Myelodysplastic syndrome; Promoter methylation; Tumor suppressor gene

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; MESSENGER RNA; TUMOR SUPPRESSOR PROTEIN; ZMYND10 PROTEIN, HUMAN;

EID: 84862287522     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-012-1151-0     Document Type: Article
Times cited : (9)

References (39)
  • 2
    • 33644878393 scopus 로고    scopus 로고
    • Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients
    • Aggerholm A, Holm MS, Guldberg P, Olesen LH, Hokland P (2006) Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. Eur J Haematol 76(1):23-32
    • (2006) Eur J Haematol , vol.76 , Issue.1 , pp. 23-32
    • Aggerholm, A.1    Holm, M.S.2    Guldberg, P.3    Olesen, L.H.4    Hokland, P.5
  • 3
    • 79954469878 scopus 로고    scopus 로고
    • Cancer epigenetics: Above and beyond
    • Brait M, Sidransky D (2011) Cancer epigenetics: above and beyond. Toxicol Mech Methods 21(4):275-288
    • (2011) Toxicol Mech Methods , vol.21 , Issue.4 , pp. 275-288
    • Brait, M.1    Sidransky, D.2
  • 5
    • 0037108309 scopus 로고    scopus 로고
    • Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment
    • Daskalakis M, Nguyen TT, Nguyen C, Guldberg P, Köhler G, Wijermans P, Jones PA, Lübbert M (2002) Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment. Blood 100(8):2957-2964
    • (2002) Blood , vol.100 , Issue.8 , pp. 2957-2964
    • Daskalakis, M.1    Nguyen, T.T.2    Nguyen, C.3    Guldberg, P.4    Köhler, G.5    Wijermans, P.6    Jones, P.A.7    Lübbert, M.8
  • 7
    • 79956329620 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: Dissecting the heterogeneity
    • Greenberg PL (2011) Myelodysplastic syndromes: dissecting the heterogeneity. J Clin Oncol 29(15):1937-1938
    • (2011) J Clin Oncol , vol.29 , Issue.15 , pp. 1937-1938
    • Greenberg, P.L.1
  • 10
    • 33846187641 scopus 로고    scopus 로고
    • Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer
    • DOI 10.1158/1078-0432.CCR-06-0894
    • Gu J, Berman D, Lu C, Wistuba II, Roth JA, Frazier M, Spitz MR, Wu X (2006) Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer. Clin Cancer Res 12(24):7329-7338 (Pubitemid 46095405)
    • (2006) Clinical Cancer Research , vol.12 , Issue.24 , pp. 7329-7338
    • Gu, J.1    Berman, D.2    Lu, C.3    Wistuba, I.I.4    Roth, J.A.5    Frazier, M.6    Spitz, M.R.7    Wu, X.8
  • 11
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • DOI 10.1056/NEJMra023075
    • Herman JG, Baylin SB (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349(21):2042-2054 (Pubitemid 37448928)
    • (2003) New England Journal of Medicine , vol.349 , Issue.21 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 12
    • 1842536844 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas
    • DOI 10.1038/sj.onc.1207407
    • Hesson L, Bièche I, Krex D, Criniere E, Hoang-Xuan K, Maher ER, Latif F (2004) Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas. Oncogene 23(13):2408-2419 (Pubitemid 38496796)
    • (2004) Oncogene , vol.23 , Issue.13 , pp. 2408-2419
    • Hesson, L.1    Bieche, I.2    Krex, D.3    Criniere, E.4    Hoang-Xuan, K.5    Maher, E.R.6    Latif, F.7
  • 13
    • 77950529126 scopus 로고    scopus 로고
    • Epigenetic changes in the myelodysplastic syndrome
    • Issa JP (2010) Epigenetic changes in the myelodysplastic syndrome. Hematol Oncol Clin North Am 24(2):317-330
    • (2010) Hematol Oncol Clin North Am , vol.24 , Issue.2 , pp. 317-330
    • Issa, J.P.1
  • 14
    • 21144446552 scopus 로고    scopus 로고
    • Frequent inactivation of RASSF1A, BLU, and SEMA3B on 3p21.3 by promoter hypermethylation and allele loss in non-small cell lung cancer
    • DOI 10.1016/j.canlet.2004.10.041, PII S0304383504008481
    • Ito M, Ito G, Kondo M, Uchiyama M, Fukui T, Mori S, Yoshioka H, Ueda Y, Shimokata K, Sekido Y (2005) Frequent inactivation of RASSF1A, BLU, and SEMA3B on 3p21.3 by promoter hypermethylation and allele loss in non-small cell lung cancer. Cancer Lett 225(1):131-139 (Pubitemid 40732776)
    • (2005) Cancer Letters , vol.225 , Issue.1 , pp. 131-139
    • Ito, M.1    Ito, G.2    Kondo, M.3    Uchiyama, M.4    Fukui, T.5    Mori, S.6    Yoshioka, H.7    Ueda, Y.8    Shimokata, K.9    Sekido, Y.10
  • 15
    • 23744468972 scopus 로고    scopus 로고
    • Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome
    • DOI 10.1038/sj.leu.2403805
    • Iwai M, Kiyoi H, Ozeki K, Kinoshita T, Emi N, Ohno R, Naoe T (2005) Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome. Leukemia 19(8):1367-1375 (Pubitemid 41136330)
    • (2005) Leukemia , vol.19 , Issue.8 , pp. 1367-1375
    • Iwai, M.1    Kiyoi, H.2    Ozeki, K.3    Kinoshita, T.4    Emi, N.5    Ohno, R.6    Naoe, T.7
  • 16
    • 78349253157 scopus 로고    scopus 로고
    • Genes link epigenetics and cancer
    • Kaiser J (2010) Genes link epigenetics and cancer. Science 330(6004):577
    • (2010) Science , vol.330 , Issue.6004 , pp. 577
    • Kaiser, J.1
  • 18
    • 33846236840 scopus 로고    scopus 로고
    • Update of the decitabine experience in higher risk myelodysplastic syndrome and analysis of prognostic factors associated with outcome
    • DOI 10.1002/cncr.22376
    • Kantarjian HM, O'Brien S, Shan J, Aribi A, Garcia-Manero G, Jabbour E, Ravandi F, Cortes J, Davisson J, Issa JP (2007) Update of the decitabine experience in higher risk myelodysplastic syndrome and analysis of prognostic factors associated with outcome. Cancer 109(2):265-273 (Pubitemid 46106241)
    • (2007) Cancer , vol.109 , Issue.2 , pp. 265-273
    • Kantarjian, H.M.1    O'Brien, S.2    Shan, J.3    Aribi, A.4    Garcia-Manero, G.5    Jabbour, E.6    Ravandi, F.7    Cortes, J.8    Davisson, J.9    Issa, J.-P.10
  • 19
    • 71149106263 scopus 로고    scopus 로고
    • Switching on epigenetic therapy
    • Karberg S (2009) Switching on epigenetic therapy. Cell 139(6):1029-1031
    • (2009) Cell , vol.139 , Issue.6 , pp. 1029-1031
    • Karberg, S.1
  • 20
    • 33846902364 scopus 로고    scopus 로고
    • Hypermethylation of two consecutive tumor suppressor genes, BLU and RASSF1A, located at 3p21.3 in cervical neoplasias
    • Lai HC, Lin YW, Chang CC, Wang HC, Chu TW, Yu MH, Chu TY (2007) Hypermethylation of two consecutive tumor suppressor genes, BLU and RASSF1A, located at 3p21.3 in cervical neoplasias. Gynecol Oncol 104(3):629-635
    • (2007) Gynecol Oncol , vol.104 , Issue.3 , pp. 629-635
    • Lai, H.C.1    Lin, Y.W.2    Chang, C.C.3    Wang, H.C.4    Chu, T.W.5    Yu, M.H.6    Chu, T.Y.7
  • 22
    • 0034327412 scopus 로고    scopus 로고
    • The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes. The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
    • Lerman MI, Minna JD (2000) The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium. Cancer Res 60(21):6116-6133
    • (2000) Cancer Res , vol.60 , Issue.21 , pp. 6116-6133
    • Lerman, M.I.1    Minna, J.D.2
  • 23
    • 61649089532 scopus 로고    scopus 로고
    • RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs
    • Lorente A, Mueller W, Urdangarín E, Lázcoz P, Lass U, von Deimling A, Castresana JS (2009) RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs. Brain Pathol 19(2):279-292
    • (2009) Brain Pathol , vol.19 , Issue.2 , pp. 279-292
    • Lorente, A.1    Mueller, W.2    Urdangarín, E.3    Lázcoz, P.4    Lass, U.5    Von Deimling, A.6    Castresana, J.S.7
  • 25
    • 77949466438 scopus 로고    scopus 로고
    • Molecular mechanisms involved in the progression of myelodysplastic syndrome
    • Nolte F, Hofmann WK (2010) Molecular mechanisms involved in the progression of myelodysplastic syndrome. Future Oncol 6(3):445-455
    • (2010) Future Oncol , vol.6 , Issue.3 , pp. 445-455
    • Nolte, F.1    Hofmann, W.K.2
  • 27
    • 2942737278 scopus 로고    scopus 로고
    • The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma
    • DOI 10.1038/sj.onc.1207632
    • Qiu GH, Tan LK, Loh KS, Lim CY, Srivastava G, Tsai ST, Tsao SW, Tao Q (2004) The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. Oncogene 23(27):4793-4806 (Pubitemid 38859468)
    • (2004) Oncogene , vol.23 , Issue.27 , pp. 4793-4806
    • Qiu, G.-H.1    Tan, L.K.S.2    Loh, K.S.3    Lim, C.Y.4    Srivastava, G.5    Tsai, S.-T.6    Tsao, S.W.7    Tao, Q.8
  • 28
    • 33947582255 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma
    • DOI 10.1016/j.canlet.2006.09.019, PII S0304383506005519
    • Riquelme E, Tang M, Baez S, Diaz A, Pruyas M, Wistuba II, Corvalan A (2007) Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma. Cancer Lett 250(1):100-106 (Pubitemid 46483848)
    • (2007) Cancer Letters , vol.250 , Issue.1 , pp. 100-106
    • Riquelme, E.1    Tang, M.2    Baez, S.3    Diaz, A.4    Pruyas, M.5    Wistuba, I.I.6    Corvalan, A.7
  • 31
    • 77953211440 scopus 로고    scopus 로고
    • High-resolution melting analysis of BLU methylation levels in gastric, colorectal, and pancreatic cancers
    • Shao Y, Zhang W, Zhang C, Wu Q, Yang H, Zhang J, Guan M, Wan J, Yu B (2010) High-resolution melting analysis of BLU methylation levels in gastric, colorectal, and pancreatic cancers. Cancer Invest 28(6):642-648
    • (2010) Cancer Invest , vol.28 , Issue.6 , pp. 642-648
    • Shao, Y.1    Zhang, W.2    Zhang, C.3    Wu, Q.4    Yang, H.5    Zhang, J.6    Guan, M.7    Wan, J.8    Yu, B.9
  • 34
  • 35
    • 0030612423 scopus 로고    scopus 로고
    • Hypermethylation of the p15(INK4B) gene in myelodysplastic syndromes
    • Uchida T, Kinoshita T, Nagai H, Nakahara Y, Saito H, Hotta T, Murate T (1997) Hypermethylation of the p15INK4B gene in myelodysplastic syndromes. Blood 90(4):1403-1409 (Pubitemid 27355412)
    • (1997) Blood , vol.90 , Issue.4 , pp. 1403-1409
    • Uchida, T.1    Kinoshita, T.2    Nagai, H.3    Nakahara, Y.4    Saito, H.5    Hotta, T.6    Murate, T.7
  • 36
    • 0036786901 scopus 로고    scopus 로고
    • The World Health Organization (WHO) classification of the myeloid neoplasms
    • Vardiman JW, Harris NL, Brunning RD (2002) The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 100(7):2292-2302
    • (2002) Blood , vol.100 , Issue.7 , pp. 2292-2302
    • Vardiman, J.W.1    Harris, N.L.2    Brunning, R.D.3
  • 38
    • 77956997072 scopus 로고    scopus 로고
    • Methylation of DNA in cancer
    • Watanabe Y, Maekawa M (2010) Methylation of DNA in cancer. Adv Clin Chem 52:145-167
    • (2010) Adv Clin Chem , vol.52 , pp. 145-167
    • Watanabe, Y.1    Maekawa, M.2
  • 39
    • 33645014254 scopus 로고    scopus 로고
    • Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas
    • Yi Lo PH, Chung Leung AC, Xiong W, Law S, Duh FM, Lerman MI, Stanbridge EJ, Lung ML (2006) Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas. Cancer Lett 234(2):184-192
    • (2006) Cancer Lett , vol.234 , Issue.2 , pp. 184-192
    • Yi Lo, P.H.1    Chung Leung, A.C.2    Xiong, W.3    Law, S.4    Duh, F.M.5    Lerman, M.I.6    Stanbridge, E.J.7    Lung, M.L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.