The analysis of exogenous ghrelin plasma activity and tissue distribution

Neuroendocrinology Letters

Volumn 33, Issue 2, 2012, Pages 191-195

  Ruchala, Marek ^a   Rafinska, Ludmila ^a   Kosowicz, Jerzy ^a   Gurgul, Edyta ^a   Sawinski, Piotr ^a   Biczysko, Maciej ^a   Lukaszyk, Andrzej ^a   Sowinski, Jerzy ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Biodistribution; Ghrelin; Half life time

Indexed keywords

GHRELIN; GHRELIN IODINE I 125; IODINE 125; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG UPTAKE; ISOTOPE LABELING; MALE; NONHUMAN; RADIOACTIVITY; RAT; TISSUE DISTRIBUTION;

EID: 84862277003     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Akamizu T, Shinomiya T, Irako T et al. (2005). Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay. J Clin Endocrinol Metab. 90: 6-9.
2. Altinova AE, Törüner FB, Aktürk M et al. (2006). Reduced serum acylated ghrelin levels in patients with hyperthyroidism. Horm Res. 65(6): 295-299.
3. Ariyasu H, Takaya K, Tagami T et al. (2001). Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab. 86: 4753-4758.
4. Arvat E, Di Vito L, Broglio F et al. (2000). Preliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest. 23: 493-495.
5. Baldanzi G, Filigheddu N, Cutrupi S et al. (2002). Ghrelin and desacyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol. 159(6): 1029-1037.
6. Braclik M, Marcisz C, Giebel S et al. (2008). Serum leptin and ghrelin levels in premenopausal women with stable body mass index during treatment of thyroid dysfunction. Thyroid. 18(5): 545-550.
7. Cummings DE, Purnell JQ, Frayo RS et al. (2001). A preprandial rise in plasma ghrelin suggests a role in meal initiation in human. Diabetes. 50: 1714-1719.
8. Cummings DE, Frayo RS, Marmonier C et al. (2004). Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab. 287(2): E297-304.
9. Dagli AF, Aydin S, Karaoglu A et al. (2009). Ghrelin expression in normal kidney tissue and renal carcinomas. Pathol Res Pract. 205(3): 165-173.
10. Diano S, Farr SA, Benoit SC et al. (2006). Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci. 9: 381-388.
11. Dixit VD, Schaffer EM, Pyle RS et al. (2004). Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest. 114(1): 57-66.
12. Ghelardoni S, Carnicelli V, Frascarelli S et al. (2006). Ghrelin tissue distribution: comparison between gene and protein expression. J Endocrinol Invest. 29: 115-121.
13. Giménez-Palop O, Giménez-Pérez G, Mauricio D et al. (2005). Circulating ghrelin in thyroid dysfunction is related to insulin resistance and not to hunger, food intake or anthropometric changes. Eur J Endocrinol. 153(1): 73-79.
14. Gjedde S, Vestergaard E, Gormsen LC et al. (2008). Serum ghrelin levels are increased in hypothyroid patients and become normalized by L-thyroxine treatment. J Clin Endocrinol Metab. 93(6): 2277-2280.
15. Gnanapavan S, Kola B, Bustin SA et al. (2002). The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab. 87: 2988-2991.
16. Grönberg M, Tsolakis AV, Magnusson L et al. (2008). Distribution of obestatin and ghrelin in human tissues: immunoreactive cells in the gastrointestinal tract, pancreas and mammary glands. J Histochem Cytochem. 56: 793-801.
17. Gualillo O, Caminos J, Blanco M et al. (2001). Ghrelin, a novel placental-derived hormone. Endocrinology. 142(2): 788-794.
18. Guan XM, Yu H, Palyha OC et al. (1997). Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res. 48: 23-29.
19. Hattori N, Saito T, Yagyu T et al. (2001). GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils. J Clin Endocrinol Metab. 86(9): 4284-4291.
20. Howard AD, Feighner SD, Cully DF et al. (1996). A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 273: 974-977.
21. Jeffery PL, Herington AC, Chopin LK (2002). Expression and action of the growth hormone-releasing peptide ghrelin and its receptor in prostate cancer cell lines. J Endocrinol. 172: R7-11.
22. Kojima M, Hosoda AH, Date Y et al. (1999). Ghrelin is a growth hormone releasing acylated peptide from stomach. Nature. 402: 656-660.
23. Lawrence CB, Snape AC, Baudoin FM et al. (2002) Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology. 143: 155-162.
24. Leite-Moreira AF, Soares JB (2007). Physiological, pathological and potential therapeutic roles of ghrelin. Drug Discov Today. 12: 276-288.
25. Nagaya N, Uematsu M, Kojima M et al. (2001). Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation. 104: 1430-1435.
26. Papotti M, Ghe C, Cassoni P et al. (2000). Growth hormone secretagog binding sites in peripheral human tissues. J Clin Endocrinol Metab. 85(10): 3803-3807.
27. Raghay K, Garcia-Caballero T, Nogueiras R et al. (2006). Ghrelin localization in rat and human thyroid and parathyroid glands and tumors. Histochem Cell Biol. 89: 400-409.
28. Riis AL, Hansen TK, Moller N et al. (|2003). Hyperthyroidism is associated with suppressed circulating ghrelin level. J Clin Endocrinol Metab. 88: 853-857.
29. Rojdmark S, Calissendorff J, Danielsson O et al. (2005). Hunger-satiety signals in patients with Graves' thyrotoxicosis before, during, and after long-term pharmacological treatment. Endocrine. 27: 55-61.
30. Ruchala M (2007). Ghrelina i somatostatyna jako modulatory sekrecji hormonów tarczycy: badania doświadczalne in vivo i in vitro oraz wynikaja̧ce z nich implikacje kliniczne (Ghrelin and somatostatin as modulators of thyroid hormones secretion: experimental studies in vivo and in vitro and their clinical implications - ethichabilitation thesis). Wydawnictwo Naukowe Uniwersytetu im. K. Marcinkowskiego. Poznań
31. Shiiya T, Nakazato M, Mizuta M et al. (2002). Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab. 87: 240-244.
32. Takaya K, Ariyasu H, Kanamoto N et al. (2000). Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab. 85: 4908-4911.
33. Tschop M, Smiley DL, Heiman ML (2000). Ghrelin induces adiposity in rodents. Nature. 407: 908-913.
34. Ueberberg B, Unger N, Saeger W et al. (2009). Expression of ghrelin and its receptor in human tissues. Horm Metab Res. 41(11): 814-821.
35. Vestergaard ET, Hansen TK, Gormsen LC et al. (2007). Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects. Am J Physiol Endocrinol Metab. 292(6): E1829-36.
36. Wren AM, Small CJ, Ward HL et al. (2000). The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology. 141: 4325-4328.
37. Wren AM, Seal LJ, Cohen MA et al. (2001). Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 86: 5992-5995.
38. Yildiz BO, Suchard MA, Wong ML et al. (2004). Alternations in the dynamics of circulating ghrelin, adiponectin and leptin in human obesity. Proc Natl Acad Sci USA. 101: 10434-10439.