Comparison of the metabolic profiling of hepatitis B virus-infected cirrhosis and alcoholic cirrhosis patients by using 1H NMR-based metabonomics

Hepatology Research

Volumn 42, Issue 7, 2012, Pages 677-685

  Qi, Suwen ^a   Tu, Zhiguang ^a   Ouyang, Xin ^b   Wang, Linxian ^a   Peng, Wujian ^b   Cai, Anji ^a   Dai, Yong ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

Author keywords

Alcoholic cirrhosis; Hepatitis B virus infected cirrhosis; Metabolic profiling; Orthogonal partial least squares discriminant analysis

Indexed keywords

ACETOACETIC ACID; BIOLOGICAL MARKER; CREATINE; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; ISOBUTYRIC ACID; LIPID; LOW DENSITY LIPOPROTEIN; SUCCINIC ACID; TYROSINE; VALINE;

ADULT; ALCOHOL LIVER CIRRHOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; FEMALE; GLUCOSE BLOOD LEVEL; HEPATITIS B; HUMAN; INTERMETHOD COMPARISON; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIVER CIRRHOSIS; MALE; PARTIAL LEAST SQUARES REGRESSION; PATHOGENESIS; PATTERN RECOGNITION; PILOT STUDY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 84862267971     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2011.00964.x     Document Type: Article

References (33)

1. Yan Y, Yang JY, Mou YH etal. Possible metabolic pathways of ethanol responsible for oxidative DNA damage in human peripheral lymphocytes. Alcohol Clin Exp Res 2011; 35: 1-9.
2. Fabris C, Toniutto P, Falleti E etal. MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption. Alcohol Clin Exp Res 2009; 33: 102-7.
3. Chen CJ, Yang HI, Iloeje UH etal. Predicting liver disease complications (HCC AND CIRRHOSIS) in patients with chronic hepatitis B infection using a risk function model: the REVEa.L. - HBV study. Gastroenterology 2006; 130: A846-A846.
4. Schuppan D, Afdhal NH. Liver cirrhosis. Lancet 2008; 371: 838-51.
5. Brechot C, Kremsdorf D, Soussan P etal. Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): molecular mechanisms and novel paradigms. Pathol Biol (Paris) 2010; 58: 278-87.
6. Toshikuni N, Izumi A, Nishino K etal. Comparison of outcomes between patients with alcoholic cirrhosis and those with hepatitis C virus-related cirrhosis. J Gastroenterol Hepatol 2009; 24: 1276-83.
7. del Olmo JA, Serra MA, Rodriguez F etal. Incidence and risk factors for hepatocellular carcinoma in 967 patients with cirrhosis. J Cancer Res Clin Oncol 1998; 124: 560-4.
8. Mas VR, Fassnacht R, Archer KJ, Maluf D. Molecular mechanisms involved in the interaction effects of alcohol and hepatitis C virus in liver cirrhosis. Mol Med 2010; 16: 287-97.
9. Jimenez B, Montoliu C, MacIntyre DA etal. Serum metabolic signature of minimal hepatic encephalopathy by (1)H-nuclear magnetic resonance. J Proteome Res 2010; 9: 5180-7.
10. Wang T, Shao K, Chu Q etal. Automics: an integrated platform for NMR-based metabonomics spectral processing and data analysis. BMC Bioinformatics 2009; 10: 83-97.
11. Schicho R, Nazyrova A, Shaykhutdinov R etal. Quantitative metabolomic profiling of serum and urine in DSS-induced ulcerative colitis of mice by (1)H NMR spectroscopy. J Proteome Res 2010; 9: 6265-73.
12. Nicholson JK, Foxall PJ, Spraul M, Farrant RD, Lindon JC. 750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma. Anal Chem 1995; 67: 793-811.
13. Viant MR. Improved methods for the acquisition and interpretation of NMR metabolomic data. Biochem Biophys Res Commun 2003; 310: 943-8.
14. De Meyer T, Sinnaeve D, Van Gasse B etal. Evaluation of standard and advanced preprocessing methods for the univariate analysis of blood serum 1H-NMR spectra. Anal Bioanal Chem 2010; 398: 1781-90.
15. Trygg J, Holmes E, Lundstedt T. Chemometrics in metabonomics. J Proteome Res 2007; 6: 469-79.
16. Kumar A, Bala L, Kalita J etal. Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis. Clin Chim Acta 2010; 411: 563-7.
17. Ni Y, Su M, Lin J etal. Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress. FEBS Lett 2008; 582: 2627-36.
18. Ayshamgul H, Batur M, Ilyar S. [1H-MRS metabonomic analysis of plasma samples of esophageal cancer patients based on different pattern recognition]. Zhonghua Zhong Liu Za Zhi 2010; 32: 681-4.
19. Wiklund S, Johansson E, Sjostrom L etal. Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal Chem 2008; 80: 115-22.
20. Delanghe J, Debuyzere M, Descheerder I etal. Early diagnosis of acute myocardial infarction by enzymatic urinary creatine determination. Clin Chem 1986; 32: 1611.
21. Geerts WJ, Jonker A, Boon L etal. In situ measurement of glutamate concentrations in the periportal, intermediate, and pericentral zones of rat liver. J Histochem Cytochem 1997; 45: 1217-29.
22. Nuwayhid NF, Johnson GF, Feld RD. Kinetic measurement of the combined concentrations of acetoacetate and beta-hydroxybutyrate in serum. Clin Chem 1988; 34: 1790-3.
23. Chen HM, Lifschitz CH. Preparation of fecal samples for assay of volatile fatty acids by gas-liquid chromatography and high-performance liquid chromatography. Clin Chem 1989; 35: 74-6.
24. Shariff MI, Ladep NG, Cox IJ etal. Characterization of urinary biomarkers of hepatocellular carcinoma using magnetic resonance spectroscopy in a Nigerian population. J Proteome Res 2010; 9: 1096-103.
25. Gao H, Lu Q, Liu X etal. Application of 1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis. Cancer Sci 2009; 100: 782-5.
26. Watford M. Glutamine and glutamate metabolism across the liver sinusoid. J Nutr 2000; 130: 983S-7S.
27. Renga B, Mencarelli A, Cipriani S etal. The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate. Biochim Biophys Acta 2011; 1812: 1522-31.
28. Tominaga T, Suzuki H, Mizuno H etal. Clinical significance of measuring plasma concentrations of glutamine and glutamate in alcoholic liver diseases. Alcohol Alcohol Suppl 1993; 1A: 103-9.
29. Longo N, Ardon O, Vanzo R, Schwartz E, Pasquali M. Disorders of creatine transport and metabolism. Am J Med Genet C Semin Med Genet 2011; 157: 72-8.
30. van Loon LJ, Murphy R, Oosterlaar AM etal. Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle. Clin Sci (Lond) 2004; 106: 99-106.
31. Waters NJ, Waterfield CJ, Farrant RD, Holmes E, Nicholson JK. Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity. Chem Res Toxicol 2005; 18: 639-54.
32. Bloemen JG, Olde Damink SW, Venema K etal. Short chain fatty acids exchange: is the cirrhotic, dysfunctional liver still able to clear them? Clin Nutr 2010; 29: 365-9.
33. Amini M, Runyon BA. Alcoholic hepatitis 2010: a clinician's guide to diagnosis and therapy. World J Gastroenterol 2010; 16: 4905-12.