Identification of quantitative trait loci for diabetic nephropathy in Kk-Ay/Ta mice

Journal of Nephrology

Volumn 25, Issue 1, 2012, Pages 127-136

  Aoki, Tatsuya ^a   Kaneko, Shigeru ^a   Tanimoto, Mitsuo ^a   Gohda, Tomohito ^a   Hagiwara, Shinji ^a   Murakoshi, Maki ^a   Ishikawa, Yuji ^a   Furukawa, Masako ^a   Funabiki, Kazuhiko ^a   Horikoshi, Satoshi ^a   Tomino, Yasuhiko ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

ACR; Diabetic nephropathy; HbA1c; KK Ay Ta mouse; QTL

Indexed keywords

HEMOGLOBIN A1C; CREATININE; GLYCOSYLATED HEMOGLOBIN;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHROMOSOME 1; CHROMOSOME 7; CHROMOSOME 9; CONTROLLED STUDY; CREATININE CLEARANCE; DIABETIC NEPHROPATHY; FASTING BODY WEIGHT; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; GLOMERULAR TO BOWMAN CAPSULE VOLUME RATIO; GLUCOSE TOLERANCE TEST; HEMOGLOBIN BLOOD LEVEL; MALE; MICROSATELLITE MARKER; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORGAN SIZE; PANCREAS ISLET SIZE; PATHOGENESIS; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; RENAL SYSTEM PARAMETERS; URINARY ALBUMIN TO CREATININE RATIO; ALLELE; ANIMAL; CHROMOSOME MAP; GENETICS; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY; METABOLISM; PANCREAS ISLET; PATHOLOGY; URINE;

ALBUMINURIA; ALLELES; ANIMALS; BODY WEIGHT; CHROMOSOME MAPPING; CREATININE; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; FEMALE; GENOTYPE; HEMOGLOBIN A, GLYCOSYLATED; ISLETS OF LANGERHANS; KIDNEY; MALE; MICE; PHENOTYPE; QUANTITATIVE TRAIT LOCI;

EID: 84862245118     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/JN.2011.8433     Document Type: Article

References (46)

1. Jones CA, Krolewski AS, Rogus J, Xue JL, Collins A, Warram JH. Epidemic of end stage renal disease in people with diabetes in the U.S. population: do we know the cause? Kidney Int. 2005;67:1684-1691.
2. Patient Registration Committee. Japanese Society for Dialysis Therapy: The current state of chronic dialysis treatment in Japan. J Jpn Soc Dial Ther. 2002;35:1155-1184.
3. Excerpts from the United States Renal Data System (USRDS). 2001 annual data report: atlas of end-stage renal disease in the United States. Am J Kidney Dis. 2001;38(Suppl 3): S1-S176.
4. Krolewski AS, Waram JH, Rand LI, Kahn CR. Epidemiologic approach to the etiology of type 1 diabetes mellitus and its complications. N Engl J Med. 1987;317:1390-1398.
5. Quinn M, Angelico MC, Warram JH, Krolewski AS. Familial factors determine the development of diabetic nephropathy in patients with IDDM. Diabetologia. 1996;39:940-945.
6. Moczulski DK, Rogus JJ, Antonellis A, Warram JH, Krolewski AS. Major susceptibility locus for nephropathy in type 1 diabetes on chromosome 3q. Diabetes. 1998;47:1164-1169.
7. Imperatore G, Hanson RL, Pettitt DJ, Kobes S, Bennett PH, Knowler WC. Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes. The Pima Diabetes Genes Group. Diabetes. 1998;47:821-830.
8. Aitman TJ, Gotoda T, Evans AL, et al. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. Nat Genet. 1997;16:197-201.
9. Kondo K, Nozawa K, Tomita T, Esaki K. Inbred strains resulting from Japanese mice. Bull Exp Anim. 1957;6:107-112.
10. Nakamura M. A diabetic strain of the mouse. Proc Jpn Acad. 1962;38:348-352.
11. Nakamura M, Yamada K. Studies on a diabetic (KK) strain of the mouse. Diabetologia. 1967;3:212-221.
12. Nakamura M, Yamada K. Further study of the diabetic (KK) strain of the mouse F1 and F2 offspring of the cross between KK and C57BL/6J mice. Proc Jpn Acad. 1963;39: 489-493.
13. Shike T, Hirose S, Kobayashi M, Funabiki K, Shirai T, Tomino Y. Susceptibility and negative epistatic loci contributing to type 2 diabetes and related phenotypes in a KK/Ta mouse model. Diabetes. 2001;50:1943-1948.
14. Shike T, Gohda T, Tanimoto M, et al. Chromosomal mapping of a quantitative trait locus for the development of albuminuria in diabetic KK/Ta mice. Nephrol Dial Transplant. 2005;20:879-885.
15. Fan Q, Shike T, Shigihara T, et al. Gene expression profile in diabetic KK/Ta mice. Kidney Int. 2003;64:1978-1985.
16. Nishimura M. Breeding of mice for diabetes mellitus. Exp Anim. 2003;18:147-157.
17. Okazaki M, Saito Y, Udaka Y, et al. Diabetic nephropathy in KK and KK-Ay mice. Exp Anim. 2003;51:191-196.
18. Ito T, Tanimoto M, Yamada K, et al. Glomerular changes in the KK-Ay/Ta mouse: a possible model for human type 2 diabetic nephropathy. Nephrology. 2006;11:29-35.
19. Suto J, Matsuura S, Imamura K, Yamanaka H, Sekikawa K. Genetics of obesity in KK mouse and effects of Ay allele on quantitative regulation. Mamm Genome. 1998;9:506-510.
20. Mogensen CE, Keane WF, Bennett PH, et al. Prevention of diabetic renal disease with special reference to microalbuminuria. Lancet. 1995;346:1080-1084.
21. Matsumoto M, Tanimoto M, Gohda T, et al. Effect of pitavastatin on type 2 diabetes mellitus nephropathy in KK-Ay/Ta mice. Metabolism. 2008;57:691-697.
22. Weibel ER. Stereological methods practical methods for biological morphometry. Vol. 1. London: Academic Press; 1979:40-116.
23. Hishiki T, Shirato I, Takahashi Y, Funabiki K, Horikoshi S, Tomino Y. Podocyte injury predicts prognosis in patients with IgA nephropathy using a small amount of renal biopsy tissue. Kidney Blood Press Res. 2001;24:99-104.
24. Manly KF. A Macintosh program for storage and analysis of experimental genetic mapping data. Mamm Genome. 1993;4:303-313.
25. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995;11:241-247.
26. Turner ST, Kardia SLR, Mosley TH, Rule AD, Boerwinkle E, de Andrade M. Influence of genomic loci on measures of chronic kidney disease in hypertensive sibships. J Am Soc Nephrol. 2006;17:2048-2055.
27. Leon JM, Freedman BI, Miller MB, et al. Genome scan of glomerular filtration rate and albuminuria: the HyperGen study. Nephrol Dial Transplant. 2007;22:763-771.
28. Placha G, Canani LH, Warram JH, Krolewski AS. Evidence for different susceptibility genes for proteinuria and ESRD in type 2 diabetes. Adv Chronic Kidney Dis. 2005;12: 155-169.
29. Dittmer J. The biology of the Ets1 proto-oncogene. Mol Cancer. 2003;2:29.
30. Raffetseder U. Mesangial cell expression of proto-oncogene Ets-1 during progression of mesangioproliferative glomerulonephritis. Kidney Int. 2004;66:622-632.
31. Naito T, Razzaque MS, Nazneen A, et al. Renal expression of the Ets-1 proto-oncogene during progression of rat crescentic glomerulonephritis. J Am Soc Nephrol. 2000;11:2243-2255.
32. Pearse DD, Tian RX, Nigro J, Iorgulescu JB, Puzis L, Jaimes EA. Angiotensin II increases the expression of the transcription factor ETS-1 in mesangial cells. Am J Physiol Renal Physiol. 2008;294:F1094-F1100.
33. Gallant S, Gilkeson G. ETS transcription factors and regulation of immunity. Arch Immunol Ther Exp (Warsz). 2006;54:149-163.
34. Zhang L, Eddy A, Teng YT, et al. An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes. Mol Cell Biol. 1995;15:6961-6970.
35. Zhang X, Gallant S, Molano I, et al. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. J Immunol. 2004;173:6481-6489.
36. Berger K, Lindh R, Wierup N, et al. Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism. PLoS ONE. 2009;4:e4671.
37. Tang Y, Osawa H, Onuma H, et al. Adipocyte-specific reduction of phosphodiesterase 3B gene expression and its restoration by JTT-501 in the obese, diabetic KKAy mouse. Eur J Endocrinol. 2001;145:93-99.
38. Cheatham B, Vlahos CJ, Cheatham L. PI 3-kinase activation is required for insulin stimulation of p70s6 kinase, DNA synthesis and glucose transporter translocation. Mol Cell Biol. 1994;14:4902-4911.
39. Feliers D, Duraisamy S, Faulkner JL, et al. Activation of renal signaling pathways in db/db mice with type 2 diabetes. Kidney Int. 2001;60:495-504.
40. Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell. 2005;8:179-183.
41. Stiles B, Groszer M, Wang S, Jiao J, Wu H. PTEN less means more. Dev Biol. 2004;273:175-184.
42. Buhman KF, Accad M, Farese RV. Mammalian acyl-CoA: cholesterol acyltransferases. Biochim Biophys Acta. 2000; 1529:142-154.
43. Ren G, Chen H, Zhang LZ, et al. A coding SNP of LHX4 gene is associated with body weight and body length in bovine. Mol Biol Rep. 2009 Mar 13. [Epub ahead of print].
44. Dattani MT. Novel insights into the aetiology and pathogenesis of hypopituitarism. Horm Res. 2004;62(Suppl 3):1-13.
45. Castinetti F, Reynaud R, Saveanu A, et al. Clinical and genetic aspects of combined pituitary hormone deficiencies. Ann Endocrinol (Paris). 2008;69:7-17.
46. Pfaeffle RW, Hunter CS, Savage JJ, et al. Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies. J Clin Endocrinol Metab. 2008;93:1062-1071.