Immunosuppressive effect of S1P1 receptor agonist FTY720

Yaoxue Xuebao

Volumn 47, Issue 4, 2012, Pages 546-550

  Zhou, Wan Qi ^a   Zhang, Hai Jing ^a   Jin, Jing ^a   Li, Yan ^a   Li, Chao ^a   Chen, Xiao Guang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

FTY720; Immunosuppressor; Laser scanning confocal; Side effect; Skin allograft

Indexed keywords

CELL RECEPTOR; FINGOLIMOD;

ARTICLE; CHO CELL; CONFOCAL MICROSCOPY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; GRAFT SURVIVAL; HEART RATE; IMMUNE DEFICIENCY; LYMPHOCYTE COUNT; NONHUMAN; SKIN ALLOGRAFT;

ANIMALS; CRICETINAE; CRICETULUS; FEMALE; GRAFT SURVIVAL; HEART RATE; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE COUNT; LYMPHOCYTES; LYMPHOPENIA; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; PROPYLENE GLYCOLS; PROTEIN BINDING; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LYSOSPHINGOLIPID; SKIN TRANSPLANTATION; SPHINGOSINE; TRANSPLANTATION, HOMOLOGOUS;

EID: 84862205879     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Fujita T, Inoue K, Yamamoto S, et al. Fungal metabolites. A potent immune-suppressive activity found in Isaria sinclairii metabolite [J]. J Immunol, 1994, 47: 208.
2. Xia BS, Li XK. FTY720: a new immunosuppressant from the Cordyceps sinensis [J]. Shanghai J Immunol, 2002, 22: 79-81.
3. Li QY, Yin HS, Chi YY. Immune inhibitory effects of FK506 combined with FTY720 on mouse skin transplantation model [J]. Shandong Med J, 2007, 47: 37-38.
4. Shimizu H, Takahashi M, Kaneko T, et al. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts [J]. Circulation, 2005, 111: 222-229. (Pubitemid 40139735)
5. Suzuki T, Jin MB, Shimamura T, et al. A new immunosuppressant, FTY720, in canine kidney transplantation: effect of single-drug, induction and combination treatments [J]. Transpl Int, 2004, 17: 574-584. (Pubitemid 40104658)
6. Lamontagne K, Lith-Wood-Evans A, Schnell C, et al. Antagonism of sphingosine-1-phosphate receptor by FTY720 inhibits angiogenesis and tumor vascularization [J]. Cancer Res, 2006, 66: 221-237.
7. Graler MH, Goetzl EJ. The immunosuppressant FTY720 down regulates sphingosine 1-phosphate G-protein-coupled receptors [J]. FASEB J, 2004, 18: 551-553.
8. Hu WM, Tang SJ, Jing BQ, et al. Study on relationship between conserved motif of sphingosine 1-phosphate receptor type 1 and FTY720-induced internalization [J]. Chin J Immunol, 2009, 25: 613-616.