Discovery and structure-activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 13, 2012, Pages 4358-4361

  Fuchi, Nobuhiro ^a   Iura, Yosuke ^a   Kaneko, Hiroaki ^a   Nitta, Aiko ^a   Suyama, Kazuharu ^a   Ueda, Hiroshi ^a   Yamaguchi, Shinichi ^a   Nishimura, Kazumi ^a   Fujii, Shigeo ^a   Sekiya, Yumiko ^a   Yamada, Masateru ^a   Takahashi, Toshiya ^a  

^a TORAY INDUSTRIES INC   (Japan)

Author keywords

CK2; Cu catalyzed N arylation; Docking study; Kinase inhibitor; Nephritis

Indexed keywords

CASEIN KINASE II; CASEIN KINASE II INHIBITOR; EMODIN; INDAZOLE DERIVATIVE; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; EXPERIMENTAL MODEL; GLOMERULONEPHRITIS; IC 50; MALE; MOLECULAR DOCKING; NONHUMAN; PROTEINURIA; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CASEIN KINASE II; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HUMANS; INDAZOLES; INJECTIONS, INTRAPERITONEAL; NEPHRITIS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRAZINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84862204027     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.006     Document Type: Article

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