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Volumn 341, Issue 9, 2008, Pages 554-561
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Structure-activity relationships of pyrazine-based CK2 inhibitors: Synthesis and evaluation of 2,6-disubstituted pyrazines and 4,6-disubstituted pyrimidines
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Author keywords
CK2; Glomerulonephritis; Kinase inhibitor; Pyrazine derivatives; SAR study
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Indexed keywords
1 [6 (1H INDOL 1 YL)PYRAZIN 2 YL] 1,4,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLIC ACID;
1 [6 (1H INDOL 1 YL)PYRAZIN 2 YL]PIPERIDINE 3 CARBOXYLIC ACID;
1 [6 (1H INDOL 1 YL)PYRAZIN 2 YL]PIPERIDINE 4 CARBOXYLIC ACID;
2 (1 (6 (3 NITROPHENYLAMINO)PYRAZIN 2 YL) 1H PYRROL 3 YL)ACETIC ACID;
2 [1 [6 (1H INDOL 1 YL)PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 (2 CHLOROPHENYLAMINO)PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 (2 TRIFLUOROMETHYLPHENYLAMINO)PYRAZIN 2 YL] 1H PYRROL 3YL]ACETIC ACID;
2 [1 [6 (3 AMINOPHENOXY)PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 (3 CHLOROPHENYLAMINO)PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 (3 CYANOPHENYLAMINO)PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 (3 FLUOROPHENYLAMINO)PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 (3 METHOXYPHENYLAMINO)PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 (3 SULFAMOYLPHENYLAMINO)PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 (3 TRIFLUOROMETHYLPHENYLAMINO)PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 (4 CHLOROPHENYLAMINO)PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 (4 FLUOROPHENYLAMINO)PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 (6 (ISOPROPYLAMINO) 1H INDAZOL 1 YL)PYRIMIDIN 4 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 [3 (ISOPROPYLAMINO)PHENOXY]PYRAZIN 2 YL] 1H PYRROL 3 YL]ACETIC ACID;
2 [1 [6 [6 (CYCLOPENTYLAMINO) 1H INDAZOL 1 YL]PYRIMIDIN 4 YL] 1H PYRROL 3 YL]ACETIC ACID;
3 [6 [3 (CARBOXYMETHYL) 1H PYRROL 1 YL]PYRAZIN 2 YLOXY]BENZOIC ACID;
3 [6 [3 (CARBOXYMETHYL) 1H PYRROL 1 YL]PYRAZIN 2YL AMINO]BENZOIC ACID;
4 [6 [3 (CARBOXYMETHYL) 1H PYRROL 1 YL]PYRAZIN 2YL AMINO]BENZOIC ACID;
4 [6 [4 (CARBOXYMETHYL) 1H PYRROL 1YL]PYRAZIN 2 YLOXY]BENZOIC ACID;
4 [[6 (1H INDOL 1 YL)PYRAZIN 2 YL]AMINO]BUTANOIC ACID;
6 [[6 (1H INDOL 1 YL)PYRAZIN 2 YL]AMINO]HEXANOIC ACID;
CASEIN KINASE 2 INHIBITOR;
CASEIN KINASE II;
PROTEIN KINASE INHIBITOR;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ARTICLE;
DRUG ACTIVITY;
DRUG POTENCY;
DRUG SCREENING;
DRUG SYNTHESIS;
ENZYME INHIBITION;
IC 50;
PRIORITY JOURNAL;
STRUCTURE ACTIVITY RELATION;
SUBSTITUTION REACTION;
CASEIN KINASE II;
ENZYME INHIBITORS;
INDICATORS AND REAGENTS;
PYRAZINES;
PYRIMIDINES;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 53549117719
PISSN: 03656233
EISSN: 15214184
Source Type: Journal
DOI: 10.1002/ardp.200700269 Document Type: Article |
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Times cited : (30)
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References (22)
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