Critical epitopes in the Nucleocapsid protein of SFTS virus recognized by a panel of SFTS patients derived human monoclonal antibodies

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Yu, Li ^a   Zhang, Li ^a   Sun, Lina ^a   Lu, Jing ^a   Wu, Wei ^a   Li, Chuan ^a   Zhang, Quanfu ^a   Zhang, Fushun ^a   Jin, Cong ^a   Wang, Xianjun ^b   Bi, Zhenqiang ^b   Li, Dexin ^a   Liang, Mifang ^a  

^a Institute for Viral Disease Control and Prevention   (China)

^b Shandong Province CDC   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; GLUTAMIC ACID; HUMAN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; NUCLEOCAPSID PROTEIN; PROTEIN GC; PROTEIN GN; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBODY DETECTION; ARTICLE; BINDING AFFINITY; BUNYAVIRUS; BUNYAVIRUS INFECTION; COMBINATORIAL LIBRARY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MOLECULAR BIOLOGY; MOLECULAR CLONING; NONHUMAN; PHAGE DISPLAY; SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS; SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS INFECTION; SFTS VIRUS; SITE DIRECTED MUTAGENESIS; VIRION;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NEUTRALIZATION TESTS; NUCLEOCAPSID PROTEINS; PHLEBOVIRUS;

EID: 84862201680     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038291     Document Type: Article

References (31)

1. Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, et al. (2011) Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364: 1523-1532.
2. Gai Z, Liang M, Zhang Y, Zhang S, Jin C, et al. (2012) Person-to-Person Transmission of Severe Fever With Thrombocytopenia Syndrome Bunyavirus Through Blood Contact. Clin Infect Dis 54: 249-252.
3. Schmaljohn CS, Nichol ST, (2007) Bunyaviridae. In: Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, editors. pp. 1741-1789 editors. Fields Virology. Philadelphia, PA: Lippincott Williams & Wilkins.
4. Martin-Folgar R, Lorenzo G, Boshra H, Iglesias J, Mateos F, et al. (2010) Development and characterization of monoclonal antibodies against Rift Valley fever virus nucleocapsid protein generated by DNA immunization. MAbs 2: 275-284.
5. Magurano F, Nicoletti L, (1999) Humoral response in Toscana virus acute neurologic disease investigated by viral-protein-specific immunoassays. Clin Diagn Lab Immunol 6: 55-60.
6. Kashyap AK, Steel J, Oner AF, Dillon MA, Swale RE, et al. (2008) Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies. Proc Natl Acad Sci U S A 105: 5986-5991.
7. Stephenson I, Wood JM, Nicholson KG, Zambon MC, (2003) Sialic acid receptor specificity on erythrocytes affects detection of antibody to avian influenza haemagglutinin. J Med Virol 70: 391-398.
8. Sun L, Lu X, Li C, Wang M, Liu Q, et al. (2009) Generation, characterization and epitope mapping of two neutralizing and protective human recombinant antibodies against influenza A H5N1 viruses. PLoS One 4: e5476.
9. Barbas CF 3rd, Lerner RA, Benkovic SJ (1991) Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci USA 88: 7978-7982.
10. Barbas CF 3rd, Burton DR (1996) Selection and evolution of high-affinity human anti-viral antibodies. Trends Biotechol 14: 230-234.
11. Lu J, Li C, Zhang FS, Wu W, Zhang QF, et al. (2011) [Expression of structural and non-structural proteins of severe fever with thrombocytopenia syndrome bunyavirus]. Bing Du Xue Bao 27: 515-520.
12. Agostino M, Sandrin MS, Thompson PE, Yuriev E, Ramsland PA, (2009) In silico analysis of antibody-carbohydrate interactions and its application to xenoreactive antibodies. Mol Immunol 47: 233-246.
13. Clark RL, Johnston BF, Suckling CJ, Mackay SP, (2006) A modelling study of a non-concerted hydrolytic cycloaddition reaction by the catalytic antibody H11. Bioorg Med Chem 14: 2674-2683.
14. Kaushik S, Sowdhamini R, (2011) Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding. PLoS One 6: e26251.
15. Cook GP, Tomlinson IM, (1995) The human immunoglobulin VH repertoire. Immunol Today 16: 237-242.
16. Raymond DD, Piper ME, Gerrard SR, Smith JL, (2010) Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation. Proc Natl Acad Sci U S A 107: 11769-11774.
17. Le May N, Gauliard N, Billecocq A, Bouloy M, (2005) The N terminus of Rift Valley fever virus nucleoprotein is essential for dimerization. J Virol 79: 11974-11980.
18. Katz A, Freiberg AN, Backstrom V, Schulz AR, Mateos A, et al. (2010) Oligomerization of Uukuniemi virus nucleocapsid protein. Virol J 7: 187.
19. Arikawa J, Schmaljohn AL, Dalrymple JM, Schmaljohn CS, (1989) Characterization of Hantaan virus envelope glycoprotein antigenic determinants defined by monoclonal antibodies. J Gen Virol 70 (Pt 3): 615-624.
20. Arikawa J, Yao JS, Yoshimatsu K, Takashima I, Hashimoto N, (1992) Protective role of antigenic sites on the envelope protein of Hantaan virus defined by monoclonal antibodies. Arch Virol 126: 271-281.
21. Boshra H, Lorenzo G, Rodriguez F, Brun A, (2011) A DNA vaccine encoding ubiquitinated Rift Valley fever virus nucleoprotein provides consistent immunity and protects IFNAR(-/-) mice upon lethal virus challenge. Vaccine 29: 4469-4475.
22. Besselaar TG, Blackburn NK, (1991) Topological mapping of antigenic sites on the Rift Valley fever virus envelope glycoproteins using monoclonal antibodies. Arch Virol 121: 111-124.
23. Lundkvist A, Horling J, Niklasson B, (1993) The humoral response to Puumala virus infection (nephropathia epidemica) investigated by viral protein specific immunoassays. Arch Virol 130: 121-130.
24. Fafetine JM, Tijhaar E, Paweska JT, Neves LC, Hendriks J, et al. (2007) Cloning and expression of Rift Valley fever virus nucleocapsid (N) protein and evaluation of a N-protein based indirect ELISA for the detection of specific IgG and IgM antibodies in domestic ruminants. Vet Microbiol 121: 29-38.
25. Jansen van Vuren P, Potgieter AC, Paweska JT, van Dijk AA, (2007) Preparation and evaluation of a recombinant Rift Valley fever virus N protein for the detection of IgG and IgM antibodies in humans and animals by indirect ELISA. J Virol Methods 140: 106-114.
26. Boshra H, Lorenzo G, Busquets N, Brun A, (2011) Rift valley fever: recent insights into pathogenesis and prevention. J Virol 85: 6098-6105.
27. Jansen van Vuren P, Tiemessen CT, Paweska JT, (2011) Anti-nucleocapsid protein immune responses counteract pathogenic effects of Rift Valley fever virus infection in mice. PLoS One 6: e25027.
28. Nakamura T, Yanagihara R, Gibbs CJ Jr, Gajdusek DC, (1985) Immune spleen cell-mediated protection against fatal Hantaan virus infection in infant mice. J Infect Dis 151: 691-697.
29. Yoshimatsu K, Yoo YC, Yoshida R, Ishihara C, Azuma I, et al. (1993) Protective immunity of Hantaan virus nucleocapsid and envelope protein studied using baculovirus-expressed proteins. Arch Virol 130: 365-376.
30. Mohl BP, Barr JN, (2009) Investigating the specificity and stoichiometry of RNA binding by the nucleocapsid protein of Bunyamwera virus. RNA 15: 391-399.
31. Kearns-Jonker M, Barteneva N, Mencel R, Hussain N, Shulkin I, et al. (2007) Use of molecular modeling and site-directed mutagenesis to define the structural basis for the immune response to carbohydrate xenoantigens. BMC Immunol 8: 3.