Consequences of NMO-IgG binding to aquaporin-4 in neuromyelitis optica

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 24, 2012, Pages

  Rossi, Andrea ^a   Ratelade, Julien ^a   Papadopoulos, Marios C ^b   Bennettc, Jeffrey L ^c   Verkman, A S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 4; IMMUNOGLOBULIN G;

CYTOTOXICITY; EDEMA; HUMAN; INTERNALIZATION; LETTER; LIGHT SCATTERING; MYELOOPTIC NEUROPATHY; PARTICLE SIZE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; WATER PERMEABILITY;

ANIMALS; AQUAPORIN 4; ASTROCYTES; BIOLOGICAL MARKERS; IMMUNOGLOBULIN G; NEUROMYELITIS OPTICA;

EID: 84862201623     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203463109     Document Type: Letter

References (5)

1. Hinson SR, et al. (2012) Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes. Proc Natl Acad Sci USA 109:1245-1250.
2. Hinson SR, et al. (2008) Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2. J Exp Med 205:2473-2481.
3. Ratelade J, Bennett JL, Verkman AS (2011) Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. J Biol Chem 286:45156-45164.
4. Phuan PW, Ratelade J, Rossi A, Tradtrantip L, Verkman AS (2012) Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 assembly in orthogonal arrays. J Biol Chem 287:13829-13839.
5. Nicchia GP, et al. (2009) Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies. Glia 57:1363-1373.