Antiproliferative activity of kinetin riboside on HCT-15 colon cancer cell line

Nucleosides, Nucleotides and Nucleic Acids

Volumn 31, Issue 6, 2012, Pages 474-481

  Rajabi, Mehdi ^a,b,c   Gorincioi, Elena ^b,d   Santaniello, Enzo ^b  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d Institutul de Chimie al Academiei de Ştiinte a Moldovei ^*  (Moldova)

Author keywords

Apoptosis; Cell cycle analysis; HCT 15 colon cancer; Kinetin riboside; Proliferation

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOKININ; KINETIN RIBOSIDE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; TUMOR GROWTH;

ADENOSINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SHAPE; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETIN; TIME FACTORS;

EID: 84862199329     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770.2012.681825     Document Type: Article

References (13)

1. Miller, C.O.; Skoog, F.; Von Saltza, M.H.; Strong, F.M. Kinetin: a cell division factor from deoxyribonucleic acid. J. Am. Chem. Soc. 1955, 77, 1392-1393.
2. Miller, C.O.; Skoog, F.; Okumura, F.S.; von Saltza, M.H.; Strong, F.M. Isolation, structure and synthesis of kinetin: a substance promoting cell division. J. Am. Chem. Soc. 1956, 78, 1375-1380.
3. Barciszewski, J.; Siboska, G.E.; Pedersen, B.O.; Clark, B.F.; Rattan, S.I. Evidence for the presence of kinetin in DNA and cell extracts. FEBS Lett. 1996, 393, 197-200. (Pubitemid 26298095)
4. Ge, L.; Yong, J.W.H.; Goh, N.K.; Chia, L.S.; Tan, S.N.; Ong, E.S. Identification of kinetin and kinetin riboside in coconut (Cocos nucifera L.) water using a combined approach of liquid chromatography-tandem mass spectrometry, high performance liquid chromatography and capillary electrophoresis. J. Chromatogr. B 2005, 829, 26-34. (Pubitemid 41773461)
5. Yong, J.W.H.; Ge, L.; Ng, Y.F.; Tan, S.N. The chemical composition and biological properties of coconut (Cocos nucifera L.) water. Molecules 2009, 14, 5144-5164.
6. Barciszewski, J.; Massino, F.; Clark, B.F.C. Kinetin: a multiactive molecule. Int. J. Biol. Macromol. 2007, 40, 182-192.
7. Griffaut, B.; Bos, R.; Maurizis, J.C.; Madelmont, J.C.; Ledoigt, G. Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells. Int. J. Biol. Macromol. 2004, 34, 271-275. (Pubitemid 39220863)
8. Orr, M.F.; McSwain, B. The effect of kinetin, kinetin ribofuranoside and gibberellic acid upon cultures of skin and mammary carcinoma and cystic disease. Cancer Res. 1960, 20, 1362-1364.
9. Cheong, J.; Goh, D.; Yong, J.W.H.; Tan, S.N.; Ong, E.S. Inhibitory effect of kinetin riboside in human heptamoa, HepG2. Mol. Biosyst. 2009, 5, 91-98.
10. Choi, B.H.; Kim, W.; Wang, Q.C.; Kim, D.C.; Tan, S.N.; Yong, J.W.H.; Kim, K.T.; Yoon, H.S. Kinetin riboside preferentially induces apoptosis bymodulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Lett. 2008, 261, 37-45.
11. 6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A (p21) upregulation in human cancer cell lines. Biochem. Pharmacol. 2009, 77, 1125-1138.
12. Tiedemann, R.E.;Mao, X.; Shi, C.X.; Zhu, Y.X.; Palmer, S.E.; Sebag, M.; Marler,R.; Chesi, M.; Fonseca, R.; Bergsagel, P.L.; Schimmer, A.D.; Stewart, A.K. Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity. J. Clin. Invest. 2008, 118, 1750-1764. (Pubitemid 351632378)
13. Damaraju, V.L.; Damaraju, S.; Young, J.D.; Baldwin, S.A.; Mackey, J.; Sawyer, M.B.; Cass, C.E. Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene. 2003, 22, 7524-7536. (Pubitemid 37487174)