Noninvasive in vivo optical detection of biofilm in the human middle ear

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 24, 2012, Pages 9529-9534

  Nguyen, Cac T ^a,b   Jung, Woonggyu ^a   Kim, Jeehyun ^c   Chaney, Eric J ^a   Novak, Michael ^d   Stewart, Charles N ^e,f   Boppart, Stephen A ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b University of Illinois at Urbana Champaign   (United States)

^c Kyungpook National University   (South Korea)

^d CARLE FOUNDATION HOSPITAL   (United States)

^e Blue Highway LLC   (United States)

^f Welch Allyn Inc   (United States)

Author keywords

Low coherence interferometry; Optical coherence tomography; Otolaryngology; Otoscopy; Primary care imaging

Indexed keywords

ADULT; ANTIBIOTIC THERAPY; ARTICLE; BIOFILM; CHRONIC OTITIS MEDIA; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; IN VIVO STUDY; INTERFEROMETRY; LOW COHERENCE INTERFEROMETRY; MIDDLE EAR; NON INVASIVE PROCEDURE; OPTICAL COHERENCE TOMOGRAPHY; OTOSCOPY; PRIORITY JOURNAL; PROBABILITY; TREATMENT RESPONSE;

BIOFILMS; EAR, MIDDLE; HUMANS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84862197919     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1201592109     Document Type: Article

References (24)

1. Klein JO (1994) Otitis media. Clin Infect Dis 19:823-833.
2. Roberts JE, Rosenfeld RM, Zeisel SA (2004) Otitis media and speech and language: a meta-analysis of prospective studies. Pediatrics 113:e238-e248.
3. Culpepper L, et al. (1993) Acute otitis media in adults: a report from the International Primary Care Network. J Am Board Family Pract 6:333-339.
4. Froom J, et al. (1997) Antimicrobials for acute otitis media? A review from the International Primary Care Network. BMJ 315:98-102. (Pubitemid 27285444)
5. Hoberman A, et al. (2011) Treatment of acute otitis media in children under 2 years of age. N Engl J Med 364:105-115.
6. Pransky SM (1998) Surgical strategies for otitis media. J Otolaryngol 27(Suppl 2): 37-42.
7. Shekelle PT, et al. (2003) Diagnosis, Natural History, and Late Effects of Otitis Media with Effusion (Agency for Healthcare Research and Quality, Rockville, MD), Evidence Report/Technology Assessment 55.
8. Harris PK, Hutchinson KM, Moravec J (2005) The use of tympanometry and pneumatic otoscopy for predicting middle ear disease. Am J Audiol 14:3-13. (Pubitemid 44756641)
9. Hall-Stoodley L, et al. (2006) Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. JAMA 296:202-211. (Pubitemid 44050374)
10. Dohar JE, et al. (2005) Mucosal biofilm formation on middle-ear mucosa in a nonhuman primate model of chronic suppurative otitis media. Laryngoscope 115:1469-1472. (Pubitemid 41105861)
11. Allegrucci M, et al. (2006) Phenotypic characterization of Streptococcus pneumoniae biofilm development. J Bacteriol 188:2325-2335.
12. Potera C (1999) Forging a link between biofilms and disease. Science 283:1837-1839.
13. Costerton JW, Stewart PS, Greenberg EP (1999) Bacterial biofilms: A common cause of persistent infections. Science 284:1318-1322. (Pubitemid 29289651)
14. Drexler W, Fujimoto J (2008) Optical Coherence Tomography: Technology and Applications (Springer, New York).
15. Zysk AM, Nguyen FT, Oldenburg AL, Marks DL, Boppart SA (2007) Optical coherence tomography: A review of clinical development from bench to bedside. J Biomed Opt 12:051403.
16. Pitris C, Saunders KT, Fujimoto JG, Brezinski ME (2001) High-resolution imaging of the middle ear with optical coherence tomography: A feasibility study. Arch Otolaryngol Head Neck Surg 127:637-642. (Pubitemid 32705868)
17. Djalilian HR, et al. (2008) Imaging the human tympanic membrane using optical coherence tomography in vivo. Otol Neurotol 29:1091-1094.
18. Xi C, Marks D, Schlachter S, Luo W, Boppart SA (2006) High-resolution three-dimensional imaging of biofilm development using optical coherence tomography. J Biomed Opt 11:34001.
19. Zysk AM, Boppart SA (2006) Computational methods for analysis of human breast tumor tissue in optical coherence tomography images. J Biomed Opt 11:054015.
20. Nguyen CT, Tu H, Chaney EJ, Stewart CN, Boppart SA (2010) Non-invasive optical interferometry for the assessment of biofilm growth in the middle ear. Biomed Opt Express 1:1104-1116.
21. Chaney EJ, Nguyen CT, Boppart SA (2011) Novel method for non-invasive induction of a middle-ear biofilm in the rat. Vaccine 29:1628-1633.
22. Lim DJ (1995) Structure and function of the tympanic membrane: A review. Acta Otorhinolaryngol Belg 49:101-115.
23. Jung W, et al. (2010) Numerical analysis of gradient index lens-based optical coherence tomography imaging probes. J Biomed Opt 15:066027.
24. Jung W, et al. (2011) Handheld optical coherence tomography scanner for primary care diagnostics. IEEE Trans Biomed Eng 58:741-744.