What Is the Maximum Time That a Unit of Red Blood Cells Can Be Safely Left Out of Controlled Temperature Storage?

Transfusion Medicine Reviews

Volumn 26, Issue 3, 2012, Pages

  Brunskill, Susan ^a,b,c   Thomas, Stephen ^a,b,c   Whitmore, Emma ^a,b,c   McDonald, Carl P ^a,b,c   Dorée, Carolyn ^a,b,c   Hopewell, Sally ^a,b,c   Staves, Julie ^a,b,c   Cardigan, Rebecca ^a,b,c   Murphy, Michael F ^a,b,c  

^a NHS BLOOD AND TRANSPLANT   (United Kingdom)

^b UK COCHRANE CENTRE   (United Kingdom)

^c OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTIC ACID;

ARTICLE; BACTERIUM CONTAMINATION; BLOOD LEVEL; CELL METABOLISM; CLINICAL PROTOCOL; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL TEMPERATURE; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; HEMOLYSIS; HUMAN; IN VIVO STUDY; PATIENT SAFETY; PH; QUALITY CONTROL; STORAGE TEMPERATURE; SYSTEMATIC REVIEW; TIME;

EID: 84862187535     PISSN: 08877963     EISSN: 15329496     Source Type: Journal    
DOI: 10.1016/j.tmrv.2011.09.005     Document Type: Article

References (44)

1. Klein H.G., Anstee D.J. Mollison's blood transfusion in clinical medicine 2005, Blackwell Publishing Ltd., Oxford. 11th ed.
2. Serious Hazards of Transfusion Annual report 2009 2010, Serious Hazards of Transfusion scheme, Manchester, UK. http://www.shotuk.org.
3. US Food and Drug Administration Fatalities reported to FDA following blood collection and transfusion. Annual summary for fiscal year 2008 http://www.fda.gov/downloads/BiologicsBloodVaccines/SafetyAvailability/BloodSafety/UCM113904.pdf.
4. British Committee for Standards in Haematology Guideline on the administration of blood components, 2009 http://www.bcshguidelines.com/documents/Admin_blood_components_bcsh_05012010.pdf.
5. UK Blood Transfusion Services Transfusion procedures. Handbook of transfusion medicine 2009, The Stationery Office, Norwich, UK. http://www.transfusionguidelines.org.uk/Index.aspx?Publication=HTM&Section=9&pageid=1114, 4th ed.
6. American Association of Blood Banks Standards for blood banks and transfusion services 2009, American Association of Blood Banks, Bethesda, MD. 26th ed.
7. Antonello O., Aprili G., Nale O. Survival of erythrocytes in glass bottles subjected to repeated displacement and temperature variations. Trasfusione del Sangue 1979, 24:276-281.
8. Matthes M., Kleine N., Engbring H. Studies on the damaging of preserved blood by changes of temperature during its storage and transport (German). Med Welt 1964, 10:490-494.
9. Strauss D., Tanzer S., Schmutzler F., et al. The effect of storage temperatures between 4 and 25 degrees centigrade on the usefulness of stored blood (German). Folia Haematol 1974, 101:243-255.
10. Strauss D., Raderecht H.J. The effect of adenine and guanosine on the survival rate of erythrocytes after storage at temperatures between 4 and 25 degrees centigrade (German). Folia Haematol 1974, 101:232-242.
11. Tibilova N.N., Agranenko V.A., Markova N.A., et al. Effect of room temperature on the storage of preserved blood and red cell mass (Russian). Gematol Transfuziol 1988, 33:21-25.
12. Ecker T., Hitzler W.E. Effect of 6-hour exposure to 20 degrees C on the ATP content and other biochemical measures of CPDA-1 packed RBCs. Clin Lab 2000, 46:291-293.
13. Gibson J.G., Sack T., Evans R.D., et al. The effect of varying temperatures on the post-transfusion survival of whole blood during depot storage and after transportation by land and air. J Clin Invest 1947, 26:747-755.
14. Hamill T.R., Hamill S.G., Busch M.P. Effects of room-temperature exposure on bacterial growth in stored RBCs. Transfusion 1990, 30:302-306.
15. Hancock V., Beard M., Naik F., et al. Effects of deviations in the recommended storage temperatures of RBCs on their invitro quality. Transfus Med 2009, 19(s1)(21):PO4. [abstract].
16. Hancock V.J., Cardigan R.A., Thomas S. Deviations in the storage temperature of RBCs-Effect on in vitro quality. Vox Sang 2010, 99(s1)(58). [5A-S32-02] [abstract].
17. Hogman C.F., de Verdier C.H., Borgstrom L. Studies on the mechanism of human red cell loss of viability during storage at +4 degrees C. II. Relation between cellular morphology and viability. Vox Sang 1987, 52:20-23.
18. Hughes Jones N.C. Storage of RBCs at temperatures between +10°C and -20°C. Br J Haematol 1958, 4:249-255.
19. Johnson V., Langeberg A., Taye-Makuri A., et al. Temperature-sensitive labels for containers of RBCs. Am J Clin Pathol 2006, 126:406-410.
20. McLaughlin N., Anderson D., Sadek I., et al. The rate leukoreduced RBC units warm when exposed to room temperature for >30 minutes. Transfusion 2010, 50(s2):74a. [abstract].
21. McLaughlin N., Sadek I., Anderson D., et al. Bacterial growth in RBC units exposed to room temperature for greater than 30 minutes. Transfusion 2010, 50(s2):76a. [abstract].
22. Perry H.E., Prasad P., Kirwan S., et al. Core temperature changes in resuspended RBCs (RBCs) and paediatric RBCs removed from refrigerated storage. Transfusion 2010, 50:174-177.
23. Pick P., Fabijanic J. Temperature changes in donor blood under different storage conditions. Transfusion 1971, 11:213-215.
24. Reid T.J., Babcock J.G., Derse-Anthony C.P., et al. The viability of autologous human RBCs stored in additive solution 5 and exposed to 25 degrees C for 24 hours. Transfusion 1999, 39:991-997.
25. Reiter U., Wagner T., Kozma N., et al. Core and surface temperature in a RBC unit during storage and transport. Vox Sang 2011, 101:10-15.
26. Ruddell J.P., Lippert L.E., Babcock J.G., et al. Effect of 24-hour storage at 25 degrees C on the in vitro storage characteristics of CPDA-1 packed RBCs. Transfusion 1998, 38:424-428.
27. Saxena S., Odono V., Uba J., et al. The risk of bacterial growth in units of blood that have warmed to more than 10 degrees C. Am J Clin Pathol 1990, 94:80-83.
28. Sharma R.R., Subramanian P.G., Kumar S., et al. Evaluation of storage conditions and bacterial proliferation in blood components. Lab Med 2004, 35:616-619.
29. Shields C.E. Studies on stored whole blood. IV. Effects of temperature and mechanical agitation on blood with and without plasma. Transfusion 1970, 10:155-162.
30. Hess J.R. An update on solutions for red cell storage. Vox Sang 2006, 91:13-19.
31. Heaton W.A. Evaluation of post transfusion recovery and survival of transfused RBCs. Transfus Med Rev 1992, 6:153-169.
32. Tinmouth A., Chin-Yee I. The clinical consequences of the red cell storage lesion. Transfus Med Rev 2001, 15:91-107.
33. van der Meer P.F., Pietersz R.N. Overnight storage of whole blood: a comparison of two designs of butane-1,4-diol cooling plates. Transfusion 2007, 47:2038-2043.
34. Wallas C.H. Sodium and potassium changes in blood bank stored human erythrocytes. Transfusion 1979, 19:210-215.
35. Strauss R.G. RBC storage and avoiding hyperkalemia from transfusions to neonates and infants. Transfusion 2010, 50:1862-1865.
36. Hogman C.F., Knutson F., Loof H. Storage of whole blood before separation: The effect of temperature on red cell 2,3 DPG and the accumulation of lactate. Transfusion 1999, 39:492-497.
37. Barrett B.B., Andersen J.W., Anderson K.C. Strategies for the avoidance of bacterial contamination of blood components. Transfusion 1993, 33:228-233.
38. Dzieczkowski J.S., Barrett B.B., Nester D., et al. Characterization of reactions after exclusive transfusion of white cell-reduced cellular blood components. Transfusion 1995, 35:20-25.
39. Vuk T., Balija M., Jukic I. Bacterial contamination of blood products 1998-2001. VIII European Congress of International Society of Blood Transfusion 2003, 272. Blackwell Publishing, Oxford, UK, [abstract].
40. Walther-Wenke G., Doerner R., Montag T., et al. Bacterial contamination of platelet concentrates prepared by different methods: results of standardized sterility testing in Germany. Vox Sang 2006, 90:177-182.
41. Wendel S., Fontao-Wendel R., Germano S., et al. Screening of bacterial contamination in a routine scale for blood component production in a Brazilian blood bank. Vox Sang 2000, 78(Suppl):376. [abstract].
42. BSMS National Health Service Blood Stocks Management Scheme Annual Report 2008-09 Available at, Accessed 6 January 2011. http://www.bloodstocks.co.uk.
43. Zimmermann R., Heidenreich D., Weisbach V., et al. In vitro quality of RBC concentrates outdated in clinical practice. Transfus Clin Biol 2003, 10:275-283.
44. Weiss D.R., Fortenbacher S., Ringwald J., et al. Transitory interruption of recommended storage conditions does not cause significant changes in in vitro parameters of leukocyte-depleted RBCs. Vox Sang 2011, 100:272-278.