Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults

Malaria Journal

Volumn 11, Issue , 2012, Pages

  Byakika Kibwika, Pauline ^a,b,c   Lamorde, Mohammed ^a,b   Mayito, Jonathan ^c   Nabukeera, Lillian ^a   Mayanja Kizza, Harriet ^a,c   Katabira, Elly ^a,c   Hanpithakpong, Warunee ^d   Obua, Celestino ^e   Pakker, Nadine ^c   Lindegardh, Niklas ^d,f   Tarning, Joel ^d,f   De Vries, Peter J ^g   Merry, Concepta ^a,b,c  

^a MAKERERE UNIVERSITY   (Uganda)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c Infectious Diseases Network for Treatment and Research in Africa   (Uganda)

^d MAHIDOL UNIVERSITY   (Thailand)

^e MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

^f CHURCHILL HOSPITAL   (United Kingdom)

^g ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Artesunate; Intravenous; Pharmacodynamics; Pharmacokinetics; Severe malaria

Indexed keywords

ARTESUNATE; DIHYDROARTEMISININ;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BLOOD SMEAR; CLINICAL ARTICLE; DEHYDRATION; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; FEMALE; HEMOGLOBINURIA; HUMAN; HYPERPYREXIA; JAUNDICE; LABORATORY TEST; LIQUID CHROMATOGRAPHY; MALARIA FALCIPARUM; MALE; MAXIMUM PLASMA CONCENTRATION; PARASITE CLEARANCE; PHARMACODYNAMICS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TREATMENT RESPONSE; UGANDA; VOMITING; WEAKNESS;

ADULT; ANTIMALARIALS; ARTEMISININS; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALARIA; MALE; PLASMA; TANDEM MASS SPECTROMETRY; UGANDA;

EID: 84862176876     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-11-132     Document Type: Article

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