Weight loss is associated with improved endothelial dysfunction via NOX2-generated oxidative stress down-regulation in patients with the metabolic syndrome

Internal and Emergency Medicine

Volumn 7, Issue 3, 2012, Pages 219-227

  Angelico, Francesco ^a   Loffredo, Lorenzo ^a   Pignatelli, Pasquale ^a   Augelletti, Teresa ^a   Carnevale, Roberto ^a   Pacella, Antonio ^a   Albanese, Fabiana ^a   Mancini, Ilaria ^a   Di Santo, Serena ^a   Del Ben, Maria ^a   Violi, Francesco ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Atherosclerosis; Diet; Endothelial dysfunction; Metabolic syndrome; Oxidative stress

Indexed keywords

ANTIOXIDANT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

AGED; ANALYSIS OF VARIANCE; ARTERIOSCLEROSIS; ARTICLE; BIOSYNTHESIS; BODY MASS; CONFIDENCE INTERVAL; DIET THERAPY; DISEASE COURSE; FEMALE; HUMAN; MALE; METABOLIC SYNDROME X; NUTRITIONAL STATUS; OUTPATIENT; OXIDATIVE STRESS; PATHOLOGY; STATISTICS; VASCULAR ENDOTHELIUM; WEIGHT REDUCTION;

AGED; ANALYSIS OF VARIANCE; ANTIOXIDANTS; ARTERIOSCLEROSIS; BODY MASS INDEX; CONFIDENCE INTERVALS; DISEASE PROGRESSION; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; METABOLIC SYNDROME X; NADPH OXIDASE; NUTRITIONAL STATUS; OUTPATIENTS; OXIDATIVE STRESS; STATISTICS AS TOPIC; WEIGHT LOSS;

EID: 84862165187     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-011-0591-x     Document Type: Article

References (39)

1. (2001) Executive summary of the third report of the national cholesterol education program (NCEP) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) JAMA 285: 2486-2497.
2. Despres JP, Lemieux I, Bergeron J et al (2008) Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol 28: 1039-1049.
3. Grundy SM (2008) Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 28: 629-636.
4. Landmesser U, Drexler H (2005) The clinical significance of endothelial dysfunction. Curr Opin Cardiol 20: 547-551.
5. Corretti MC, Anderson TJ, Benjamin EJ et al (2002) Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the international brachial artery reactivity task force. J Am Coll Cardiol 39: 257-265.
6. Singh U, Jialal I (2006) Oxidative stress and atherosclerosis. Pathophysiology 13: 129-142.
7. Cangemi R, Angelico F, Loffredo L et al (2007) Oxidative stress-mediated arterial dysfunction in patients with metabolic syndrome: effect of ascorbic acid. Free Radic Biol Med 43: 853-859.
8. Hamburg NM, Larson MG, Vita JA et al (2008) Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease. Am J Cardiol 101: 82-88.
9. Joannides R, Haefeli WE, Linder L et al (1995) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 91: 1314-1319.
10. Cooke JP (2003) Flow, NO, and atherogenesis. Proc Natl Acad Sci USA 100: 768-770.
11. Heiss C, Lauer T, Dejam A et al (2006) Plasma nitroso compounds are decreased in patients with endothelial dysfunction. J Am Coll Cardiol 47: 573-579.
12. Loffredo L, Marcoccia A, Pignatelli P et al (2007) Oxidative-stress-mediated arterial dysfunction in patients with peripheral arterial disease. Eur Heart J 28: 608-612.
13. Cai H, Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-844.
14. Violi F, Marino R, Milite MT, Loffredo L (1999) Nitric oxide and its role in lipid peroxidation. Diabetes Metab Res Rev 15: 283-288.
15. Dai J, Jones DP, Goldberg J et al (2008) Association between adherence to the Mediterranean diet and oxidative stress. Am J Clin Nutr 88: 1364-1370.
16. Rallidis LS, Lekakis J, Kolomvotsou A et al (2009) Close adherence to a Mediterranean diet improves endothelial function in subjects with abdominal obesity. Am J Clin Nutr 90: 263-268.
17. Forstermann U (2008) Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 5: 338-349.
18. Bendall JK, Rinze R, Adlam D et al (2007) Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice. Circ Res 100: 1016-1025.
19. Oelze M, Warnholtz A, Faulhaber J et al (2006) NADPH oxidase accounts for enhanced superoxide production and impaired endothelium-dependent smooth muscle relaxation in BKbeta1-/- mice. Arterioscler Thromb Vasc Biol 26: 1753-1759.
20. Jung O, Schreiber JG, Geiger H, Pedrazzini T, Busse R, Brandes RP (2004) gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. Circulation 109: 1795-1801.
21. Violi F, Sanguigni V, Carnevale R et al (2009) Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study. Circulation 120: 1616-1622.
22. Alberti KG, Zimmet P, Shaw J (2006) Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 23: 469-480.
23. Wang Z, Ciabattoni G, Creminon C et al (1995) Immunological characterization of urinary 8-epi-prostaglandin F2 alpha excretion in man. J Pharmacol Exp Ther 275: 94-100.
24. Pignatelli P, Carnevale R, Cangemi R et al (2010) Atorvastatin inhibits gp91phox circulating levels in patients with hypercholesterolemia. Arterioscler Thromb Vasc Biol 30: 360-367.
25. Fortuno A, Bidegain J, Robador PA et al (2009) Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension. Hypertension 54: 744-750.
26. Fito M, Guxens M, Corella D et al (2007) Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial. Arch Intern Med 167: 1195-1203.
27. Shai I, Schwarzfuchs D, Henkin Y et al (2008) Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med 359: 229-241.
28. Sacks FM, Bray GA, Carey VJ et al (2009) Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 360: 859-873.
29. Keogh JB, Brinkworth GD, Noakes M, Belobrajdic DP, Buckley JD, Clifton PM (2008) Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity. Am J Clin Nutr 87: 567-576.
30. Keogh JB, Brinkworth GD, Clifton PM (2007) Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin. Br J Nutr 98: 852-859.
31. Williams IL, Chowienczyk PJ, Wheatcroft SB et al (2005) Endothelial function and weight loss in obese humans. Obes Surg 15: 1055-1060.
32. Bigornia SJ, Mott MM, Hess DT et al (2010) Long-term successful weight loss improves vascular endothelial function in severely obese individuals. Obesity (Silver Spring) 18: 754-759.
33. Davi G, Guagnano MT, Ciabattoni G et al (2002) Platelet activation in obese women: role of inflammation and oxidant stress. JAMA 288: 2008-2014.
34. Szabo C, Day BJ, Salzman AL (1996) Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger. FEBS Lett 381: 82-86.
35. Carnevale R, Pignatelli P, Di Santo S et al (2010) Atorvastatin inhibits oxidative stress via adiponectin-mediated NADPH oxidase down-regulation in hypercholesterolemic patients. Atherosclerosis 213: 225-234.
36. Furukawa S, Fujita T, Shimabukuro M et al (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114: 1752-1761.
37. Nakanishi S, Yamane K, Kamei N, Nojima H, Okubo M, Kohno N (2005) A protective effect of adiponectin against oxidative stress in Japanese Americans: the association between adiponectin or leptin and urinary isoprostane. Metabolism 54: 194-199.
38. Tao L, Gao E, Jiao X et al (2007) Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Circulation 115: 1408-1416.
39. Shai I, Spence JD, Schwarzfuchs D et al (2010) Dietary intervention to reverse carotid atherosclerosis. Circulation 121: 1200-1208.