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Volumn 19, Issue 18, 2011, Pages 5334-5341

5a-Carba-β-d-glucopyranose derivatives as novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

(19) Ohtake, Yoshihito a Sato, Tsutomu a Matsuoka, Hiroharu a Nishimoto, Masahiro a Taka, Naoki a Takano, Koji a Yamamoto, Keisuke a Ohmori, Masayuki a Higuchi, Takashi a Murakata, Masatoshi a Kobayashi, Takamitsu a Morikawa, Kazumi a Shimma, Nobuo a Suzuki, Masayuki a Hagita, Hitoshi a Ozawa, Kazuharu a Yamaguchi, Koji a Kato, Motohiro a Ikeda, Sachiya a

a CHUGAI PHARMACEUTICAL CO LTD (Japan)

Author keywords

5a Carba d glucopyranose; Carbasugar; Metabolic stabilization; SGLT2 inhibitor; Type 2 diabetes

Indexed keywords

(2 BENZYLPHENYL) 5A CARBA BETA DEXTRO GLUCOPYRANOSIDE; 1 BENZYLOXY 2 (4 CYCLOPROPYLBENZYL)BENZENE; 2 (2,3,4,6 TETRA O BENZYL 5A CARBA BETA DEXTRO GLUCOPYRANOSYL)BENZALDEHYDE; 2 (2,3,4,6 TETRA O BENZYL 5A CARBA BETA DEXTRO GLUCOPYRANOSYL)BENZOIC METHYL ESTER; 2 (2,3,4,6 TETRA O BENZYL 5A CARBA BETA DEXTRO GLUCOPYRANOSYL)BENZYL ALCOHOL; 2 (4 BROMOBENZYL)PHENOL; 2 (4 CHLOROBENZYL)PHENOL; 2 (4 CYCLOPROPYLBENZYL)PHENOL; 2 (4 ETHOXYBENZYL)PHENOL; 2 (4 FLUOROBENZYL)PHENOL; 2 (4 ISOPROPYLBENZYL)PHENOL; 2 (4 METHYLSULFANYLBENZYL)PHENOL; 2 (4 TRIFLUOROMETHYLBENZYL)PHENOL; 2 BENZYLOXYPHENYL (4 CYCLOPROPYLBENZYL)METHANOL; 2,3,4 TRISBENZYLOXY (5 BENZYLOXYMETHYL)CYCLOHEXYL TRIFLUOROMETHANESULFONATE; 2,3,4,6 TETRA O BENZYL 5A CARBA ALPHA DEXTRO GLUCOPYRANOSE; 5A CARBA BETA DEXTRO GLUCOPYRANOSE DERIVATIVE; [2 (2,3,4,6 TETRA O BENZYL 5A CARBA BETA DEXTRO GLUCOPYRANOSYL)PHENYL] 4 METHOXYPHENYLMETHANOL; [2 (4 ETHOXYBENZYL)PHENYL] 5A CARBA BETA DEXTRO GLUCOPYRANOSIDE; [2 (4 ETHYLBENZYL)PHENYL] 5A CARBA BETA DEXTRO GLUCOPYRANOSIDE; [2 (4 ISOPROPYLBENZYL)PHENYL] 5A CARBA BETA DEXTRO GLUCOPYRANOSIDE; [2 (4 METHOXYBENZYL)PHENYL] 5A CARBA BETA DEXTRO GLUCOPYRANOSIDE; [2 (4 METHYLBENZYL)PHENYL] 5A CARBA BETA DEXTRO GLUCOPYRANOSIDE; [2 (4 NPROPYLBENZYL)PHENYL] 5A CARBA BETA DEXTRO GLUCOPYRANOSIDE; [2 (4 VINYLBENZYL)PHENYL] 5A CARBA BETA DEXTRO GLUCOPYRANOSIDE; AGLYCONE; ANTIDIABETIC AGENT; SERGLIFLOZIN ETABONATE; SODIUM GLUCOSE COTRANSPORTER 2; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; LIPOPHILICITY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTON NUCLEAR MAGNETIC RESONANCE; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; GLUCOSE; MALE; MICE; MICE, OBESE; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; SODIUM-GLUCOSE TRANSPORTER 2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

MUS;

EID: 80052572117 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.08.005 Document Type: Article

Times cited : (19)

References (22)

1
- 0028784958
- G. You, W.S. Lee, E.J.G. Barros, Y. Kanai, T.L. Huo, S. Khawaja, R.G. Wells, S.K. Nigam, and M.A. Hediger J. Biol. Chem. 270 1995 29365
- (1995) J. Biol. Chem. , vol.270 , pp. 29365
- You, G.¹ Lee, W.S.² Barros, E.J.G.³ Kanai, Y.⁴ Huo, T.L.⁵ Khawaja, S.⁶ Wells, R.G.⁷ Nigam, S.K.⁸ Hediger, M.A.⁹

2
- 0036368517
- E.M. Wright, E. Turk, and M.G. Martin Cell Biochem. Biophys. 36 2002 115
- (2002) Cell Biochem. Biophys. , vol.36 , pp. 115
- Wright, E.M.¹ Turk, E.² Martin, M.G.³

3
- 77949429493
- S. Nomura Curr. Top. Med. Chem. 10 2010 411
- (2010) Curr. Top. Med. Chem. , vol.10 , pp. 411
- Nomura, S.¹

4
- 12744253796
- J.R.L. Ehrenkanz, N.G. Lewis, C.R. Kahn, and J. Roth Diabates/Metab. Res. Rev. 21 2005 31
- (2005) Diabates/Metab. Res. Rev. , vol.21 , pp. 31
- Ehrenkanz, J.R.L.¹ Lewis, N.G.² Kahn, C.R.³ Roth, J.⁴

5
- 0032850016
- A. Oku, K. Ueta, K. Arakawa, T. Ishihara, M. Nawano, Y. Kuronuma, M. Matsumoto, A. Saito, K. Tsujihara, M. Anai, T. Asano, Y. Kanai, and H. Endou Diabetes 48 1999 1794
- (1999) Diabetes , vol.48 , pp. 1794
- Oku, A.¹ Ueta, K.² Arakawa, K.³ Ishihara, T.⁴ Nawano, M.⁵ Kuronuma, Y.⁶ Matsumoto, M.⁷ Saito, A.⁸ Tsujihara, K.⁹ Anai, M.¹⁰ Asano, T.¹¹ Kanai, Y.¹² Endou, H.¹³

6
- 0033619999
- K. Tsujihara, M. Hongu, K. Saito, H. Kawanishi, K. Kuriyama, M. Matsumoto, A. Oku, K. Ueta, M. Tsuda, and A. Saito J. Med. Chem. 42 1999 5311
- (1999) J. Med. Chem. , vol.42 , pp. 5311
- Tsujihara, K.¹ Hongu, M.² Saito, K.³ Kawanishi, H.⁴ Kuriyama, K.⁵ Matsumoto, M.⁶ Oku, A.⁷ Ueta, K.⁸ Tsuda, M.⁹ Saito, A.¹⁰

7
- 80052599703
- PCT Int. Appl. WO2003011880
- Fushimi, N.; Ito, F.; Isaji, M. PCT Int. Appl. WO2003011880, 2004.
- (2004)
- Fushimi, N.¹ Ito, F.² Isaji, M.³

8
- 33845873376
- K. Katsuno, Y. Fujimori, Y. Takemura, M. Hiratochi, F. Itoh, Y. Komatsu, H. Fujikura, and M. Isaji J. Pharmacol. Exp. Ther. 320 2007 323
- (2007) J. Pharmacol. Exp. Ther. , vol.320 , pp. 323
- Katsuno, K.¹ Fujimori, Y.² Takemura, Y.³ Hiratochi, M.⁴ Itoh, F.⁵ Komatsu, Y.⁶ Fujikura, H.⁷ Isaji, M.⁸

9
- 52649083832
- Y. Fujimori, K. Katsuno, I. Nakashima, Y. Ishikawa-Takemura, H. Fujikura, and M. Isaji J. Pharmacol. Exp. Ther. 327 2008 268
- (2008) J. Pharmacol. Exp. Ther. , vol.327 , pp. 268
- Fujimori, Y.¹ Katsuno, K.² Nakashima, I.³ Ishikawa-Takemura, Y.⁴ Fujikura, H.⁵ Isaji, M.⁶

10
- 41649087328
- W. Meng, B.A. Ellsworth, A.A. Nirschl, P.J. McCann, M. Patel, R.N. Girotra, G. Wu, P.M. Sher, E.P. Morrison, S.A. Biller, R. Zahler, P.P. Deshpande, A. Pullockaran, D.L. Hagan, N. Morgan, J.R. Taylor, M.T. Obermeier, W.G. Humphreys, A. Khanna, L. Discenza, J.G. Robertson, A. Wang, S. Han, W.N. Wetterau, E.B. Janovitz, O.P. Flint, J.M. Whaley, and W.N. Washburn J. Med. Chem. 51 2008 1145
- (2008) J. Med. Chem. , vol.51 , pp. 1145
- Meng, W.¹ Ellsworth, B.A.² Nirschl, A.A.³ McCann, P.J.⁴ Patel, M.⁵ Girotra, R.N.⁶ Wu, G.⁷ Sher, P.M.⁸ Morrison, E.P.⁹ Biller, S.A.¹⁰ Zahler, R.¹¹ Deshpande, P.P.¹² Pullockaran, A.¹³ Hagan, D.L.¹⁴ Morgan, N.¹⁵ Taylor, J.R.¹⁶ Obermeier, M.T.¹⁷ Humphreys, W.G.¹⁸ Khanna, A.¹⁹ Discenza, L.²⁰ more..

11
- 64549142812
- W.N. Washburn J. Med. Chem. 52 2009 1785
- (2009) J. Med. Chem. , vol.52 , pp. 1785
- Washburn, W.N.¹

12
- 77956319973
- S. Nomura, S. Sakamaki, M. Hongu, E. Kawanishi, Y. Koga, T. Sakamoto, Y. Yamamoto, K. Ueta, H. Kimata, K. Nakayama, and M. Tsuda-Tsukimoto J. Med. Chem. 53 2010 6355
- (2010) J. Med. Chem. , vol.53 , pp. 6355
- Nomura, S.¹ Sakamaki, S.² Hongu, M.³ Kawanishi, E.⁴ Koga, Y.⁵ Sakamoto, T.⁶ Yamamoto, Y.⁷ Ueta, K.⁸ Kimata, H.⁹ Nakayama, K.¹⁰ Tsuda-Tsukimoto, M.¹¹

13
- 80052560882
- PCT Int. Appl. WO2004014931
- Sato, M.; Kakinuma, H.; Asanuma, H. PCT Int. Appl. WO2004014931, 2004; Chem. Abstr. 2004, 140, 199631.
- (2004)
- Sato, M.¹ Kakinuma, H.² Asanuma, H.³

14
- 77951143723
- H. Kakinuma, T. Oi, Y. Hashimoto-Tsuchiya, M. Arai, Y. Kawakita, Y. Fukasawa, I. Iida, N. Hagima, H. Takeuchi, Y. Chino, J. Asami, L. Okumura-Kitajima, F. Io, D. Yamamoto, N. Miyata, T. Takahashi, S. Uchida, and K. Yamamoto J. Med. Chem. 53 2010 3247
- (2010) J. Med. Chem. , vol.53 , pp. 3247
- Kakinuma, H.¹ Oi, T.² Hashimoto-Tsuchiya, Y.³ Arai, M.⁴ Kawakita, Y.⁵ Fukasawa, Y.⁶ Iida, I.⁷ Hagima, N.⁸ Takeuchi, H.⁹ Chino, Y.¹⁰ Asami, J.¹¹ Okumura-Kitajima, L.¹² Io, F.¹³ Yamamoto, D.¹⁴ Miyata, N.¹⁵ Takahashi, T.¹⁶ Uchida, S.¹⁷ Yamamoto, K.¹⁸

15
- 70350075459
- N.C. Goodwin, R. Mabon, B.A. Harrison, M.K. Shadoan, Z.Y. Almstead, Y. Xie, J. Healy, L.M. Buhring, C.M. DaCosta, J. Bardenhagen, F. Mseeh, Q. Liu, A. Nouraldeen, A.G.E. Wilson, S.D. Kimball, D.R. Powell, and D.B. Rawlins J. Med. Chem. 52 2009 6201
- (2009) J. Med. Chem. , vol.52 , pp. 6201
- Goodwin, N.C.¹ Mabon, R.² Harrison, B.A.³ Shadoan, M.K.⁴ Almstead, Z.Y.⁵ Xie, Y.⁶ Healy, J.⁷ Buhring, L.M.⁸ Dacosta, C.M.⁹ Bardenhagen, J.¹⁰ Mseeh, F.¹¹ Liu, Q.¹² Nouraldeen, A.¹³ Wilson, A.G.E.¹⁴ Kimball, S.D.¹⁵ Powell, D.R.¹⁶ Rawlins, D.B.¹⁷

16
- 76649110175
- R.P. Robinson, V. Mascitti, C.M. Boustany-Kari, C.L. Carr, P.M. Foley, E. Kimoto, M.T. Leininger, A. Lowe, M.K. Klenotic, J.I. MacDonald, R.J. Maguire, V.M. Masterson, T.S. Maurer, Z. Miao, J.D. Patel, C. Préville, M.R. Reese, L. She, C.M. Steppan, B.A. Thuma, and T. Zhu Bioorg. Med. Chem. Lett. 20 2010 1569
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 1569
- Robinson, R.P.¹ Mascitti, V.² Boustany-Kari, C.M.³ Carr, C.L.⁴ Foley, P.M.⁵ Kimoto, E.⁶ Leininger, M.T.⁷ Lowe, A.⁸ Klenotic, M.K.⁹ MacDonald, J.I.¹⁰ Maguire, R.J.¹¹ Masterson, V.M.¹² Maurer, T.S.¹³ Miao, Z.¹⁴ Patel, J.D.¹⁵ Préville, C.¹⁶ Reese, M.R.¹⁷ She, L.¹⁸ Steppan, C.M.¹⁹ Thuma, B.A.²⁰ Zhu, T.²¹ more..

17
- 34249893345
- O. Arjona, A.M. Gómez, J.C. López, and J. Plumet Chem. Rev. 107 2007 1919
- (2007) Chem. Rev. , vol.107 , pp. 1919
- Arjona, O.¹ Gómez, A.M.² López, J.C.³ Plumet, J.⁴

18
- 80052586598
- PCT Int. Appl. WO2006011469; EP1783110
- Matsuoka, H.; Sato, T.; Nishimoto, M.; Shimma N. PCT Int. Appl. WO2006011469, 2006; EP1783110.
- (2006)
- Matsuoka, H.¹ Sato, T.² Nishimoto, M.³ Shimma, N.⁴

19
- 84988060663
- H. Tsunoda, and S. Ogawa Liebigs Ann. 2 1995 267
- (1995) Liebigs Ann. , vol.2 , pp. 267
- Tsunoda, H.¹ Ogawa, S.²

20
- 0002780860
- A.V.R.L. Sudha, and M. Nagarajan Chem. Commun. 1998 925
- (1998) Chem. Commun. , pp. 925
- Sudha, A.V.R.L.¹ Nagarajan, M.²

21
- 0004000187
- R.C. Huston, A. Neeley, B.L. Fayerweather, H.M. D'Arcy, F.H. Maxfield, M.M. Ballard, and W.C. Lewis J. Am. Chem. Soc. 55 1933 2146
- (1933) J. Am. Chem. Soc. , vol.55 , pp. 2146
- Huston, R.C.¹ Neeley, A.² Fayerweather, B.L.³ D'Arcy, H.M.⁴ Maxfield, F.H.⁵ Ballard, M.M.⁶ Lewis, W.C.⁷

22
- 80052598288
- PCT Int. Appl. WO04052902
- Frick, W.; Glombik, H.; Kramer, W.; Heuer, H.; Brummerhop, H.; Plettemburg, O. PCT Int. Appl. WO04052902, 2004.
- (2004)
- Frick, W.¹ Glombik, H.² Kramer, W.³ Heuer, H.⁴ Brummerhop, H.⁵ Plettemburg, O.⁶

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