Targeted molecular imaging: Target significance and probe validation

JACC: Cardiovascular Imaging

Volumn 5, Issue 6, 2012, Pages 616-618

  Eckelman, William C ^a  

^a Molecular Tracer LLC   (United States)

Author keywords

clinical impact; disease control points; personalized medicine; quality control; targeted probes

Indexed keywords

ALPRENOLOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMATINIB; LISINOPRIL; RADIOISOTOPE; TRASTUZUMAB;

COST EFFECTIVENESS ANALYSIS; DIAGNOSTIC IMAGING; DRUG TARGETING; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOMICS; HYPERTENSION; MOLECULAR IMAGING; NOTE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SIGNAL PROCESSING; SINGLE NUCLEOTIDE POLYMORPHISM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; VALIDATION PROCESS;

EID: 84862155606     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2012.02.013     Document Type: Editorial

References (17)

1. W.G. Feero, A.E. Guttmacher, F.S. Collins Genomic medicine - an updated primer N Engl J Med 362 2010 2001 2011
2. C.P. Carden, D. Sarker, S. Postel-Vinay Can molecular biomarker-based patient selection in Phase 1 trials accelerate anticancer drug development? Drug Discovery Today 15 2010 88 97
3. S. Ripke, A.R. Sanders, K.S. Kendler Genome-wide association study identifies five new schizophrenia loci Nat Genet 43 2011 969 976
4. C.T. Dollery Beyond genomics Clin Pharmacol Ther 82 2007 366 370 (Pubitemid 47414367)
5. E.E. Schadt, B. Zhang, J. Zhu Advances in systems biology are enhancing our understanding of disease and moving us closer to novel disease treatments Genetica 136 2009 259 269
6. V. Dilsizian, W.C. Eckelman, M.L. Loredo, E.M. Jagoda, J. Shirani Evidence for tissue angiotensin-converting-enzyme in explanted hearts of ischemic cardiomyopathy using targeted radiotracer technique J Nucl Med 48 2007 182 187 (Pubitemid 47555341)
7. B. Riemann, M. Schäfers, M.P. Law, T. Wichter, O. Schober Radioligands for imaging myocardial alpha- and beta-adrenoceptors Nuklearmedizin 42 2003 4 9 (Pubitemid 36231684)
8. H. Kobayashi, M.R. Longmire, M. Ogawa, P.L. Choyke Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals Chem Soc Rev 40 2011 4626 4648
9. A. Chopra, L. Shan, W.C. Eckelman, K. Leung, A.E. Menkens Important parameters to consider for the characterization of PET and SPECT imaging probes Nucl Med Biol 38 2011 1079 1084
10. A. Chopra, L. Shan, W.C. Eckelman Molecular imaging and contrast agent database (MICAD): evolution and progress Mol Imaging Biol 14 2012 4 13
11. H.J. Motulsky Analyzing Data with GraphPad Prism 2009 GraphPad Software Inc San Diego, CA www.graphpad.com Accessed April 21, 2012
12. W.C. Eckelman Design criteria for targeted molecules: muscarinic cholinergic systems biology M.J. Welch, W.C. Eckelman, Targeted Molecular Imaging 2012 CRC Press, Taylor & Francis Group Boca Raton, FL 201 215
13. M.A. Mintun, M.E. Raichle, M.R. Kilbourn, G.F. Wooten, M.J. Welch A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography Ann Neurol 15 1984 217 227 (Pubitemid 14164735)
14. R.E. Carson Tracer kinetic modeling, positron emission tomography P.E. Valk, D.L. Bailey, D.W. Townsend, M.N. Maisey, Basic Science and Clinical Practice 2003 Springer-Verlag London, UK 147 179
15. T. Hara, B. Bhayana, B. Thompson Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence J Am Coll Cardiol Img 5 2012 607 615
16. V. Dilsizian, T.K. Zynda, A. Petrov Molecular imaging of human ACE-1 expression in transgenic rats J Am Coll Cardiol Img 5 2012 409 418
17. M.J. Welch, W.C. Eckelman Targeted Molecular Imaging 2012 CRC Press, Taylor & Francis Boca Raton, FL