Methyltransferase inhibitor adenosine dialdehyde suppresses androgen receptor expression and prostate cancer growth

Journal of Urology

Volumn 188, Issue 1, 2012, Pages 300-306

  Shiota, Masaki ^a   Takeuchi, Ario ^a   Yokomizo, Akira ^a   Kashiwagi, Eiji ^a   Tatsugami, Katsunori ^a   Naito, Seiji ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

androgen; drug resistance; gene expression; neoplasm; prostate; prostatic neoplasms; receptors

Indexed keywords

ADENOSINE DIALDEHYDE; ANDROGEN RECEPTOR; HISTONE H3; METHYLTRANSFERASE INHIBITOR; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR TWIST1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CASTRATION; CELL SURVIVAL; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CYTOTOXICITY; GENE EXPRESSION; HISTONE METHYLATION; HUMAN; HUMAN CELL; MALE; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; XENOGRAFT;

ADENOSINE; ANDROGENS; ANIMALS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; METHYLTRANSFERASES; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANDROGEN; RNA, NEOPLASM; TUMOR CELLS, CULTURED;

EID: 84862123496     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2012.02.2553     Document Type: Article

References (29)

1. H. Miyamoto, E.M. Messing, C. Chang Androgen deprivation therapy for prostate cancer: current status and future prospects Prostate 61 2004 332
2. B. Seruga, A. Ocana, I.F. Tannock Drug resistance in metastatic castration-resistant prostate cancer Nat Rev Clin Oncol 8 2011 12
3. P.A. Jones, S.B. Baylin The epigenomics of cancer Cell 128 2007 683
4. T.B. Miranda, P.A. Jones DNA methylation: the nuts and bolts of repression J Cell Physiol 213 2007 384
5. P. Chi, C.D. Allis, G.G. Wang Covalent histone modifications - miswritten, misinterpreted and mis-erased in human cancers Nat Rev Cancer 10 2010 457
6. A. Barski, S. Cuddapah, K. Cui High-resolution profiling of histone methylations in the human genome Cell 129 2007 823
7. T.S. Mikkelsen, M. Ku, D.B. Jaffe Genome-wide maps of chromatin state in pluripotent and lineage-committed cells Nature 448 2007 553
8. D.B. Seligson, S. Horvath, T. Shi Global histone modification patterns predict risk of prostate cancer recurrence Nature 435 2005 1262
9. M. Shiota, Y. Song, A. Yokomizo Human heterochromatin protein 1 isoform HP1β enhances androgen receptor activity and is implicated in prostate cancer growth Endocr Relat Cancer 17 2010 455
10. G. Egger, A.M. Aparicio, S.G. Escobar Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2′-deoxycytidine treatment Cancer Res 67 2007 346
11. P.K. Chiang Biological effects of inhibitors of S-adenosylhomocysteine hydrolase Pharmacol Ther 77 1998 115
12. J. Tan, X. Yang, L. Zhuang Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells Genes Dev 21 2007 1050
13. T.B. Miranda, C.C. Cortez, C.B. Yoo DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation Mol Cancer Ther 8 2009 1579
14. C.W. Gregory, K.G. Hamil, D. Kim Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes Cancer Res 58 1998 5718
15. C.D. Chen, D.S. Welsbie, C. Tran Molecular determinants of resistance to antiandrogen therapy Nat Med 10 2004 33
16. O.L. Zegarra-Moro, L.J. Schmidt, H. Huang Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells Cancer Res 62 2002 1008
17. M. Shiota, A. Yokomizo, Y. Tada Castration resistance of prostate cancer cells caused by castration-induced oxidative stress through Twist1 and androgen receptor overexpression Oncogene 29 2010 237
18. M. Shiota, A. Yokomizo, E. Kashiwagi Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin Cancer Sci 101 2010 1177
19. J.A. Rosenfeld, Z. Wang, D.E. Schones Determination of enriched histone modifications in non-genic portions of the human genome BMC Genomics 10 2009 143
20. M. Shiota, A. Yokomizo, S. Naito Increased androgen receptor transcription: a cause of castration-resistant prostate cancer and a possible therapeutic target J Mol Endocrinol 47 2011 R25
21. Z. Song, Z. Zhou, S. Uriarte S-adenosylhomocysteine sensitizes to TNF-α hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease Hepatology 40 2004 989
22. I.I. Kruman, R.P. Wersto, F. Cardozo-Pelaez Cell cycle activation linked to neuronal cell death initiated by DNA damage Neuron 41 2004 549
23. L. Jackson-Grusby, C. Beard, R. Possemato Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation Nat Genet 27 2001 31
24. I. Stancheva, C. Hensey, R.R. Meehan Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryos EMBO J 20 2001 1963
25. A.R. Karpf, B.C. Moore, T.O. Ririe Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2′-deoxycytidine Mol Pharmacol 59 2001 751
26. R. Schneider-Stock, M. Diab-Assef, A. Rohrbeck 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms J Pharmacol Exp Ther 312 2005 525
27. Y.H. Song, M. Shiota, K. Kuroiwa The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer Mod Pathol 24 2011 1272
28. C. Schwerk, K. Schulze-Osthoff Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death Oncogene 24 2005 7002
29. M. Shiota, H. Izumi, A. Tanimoto Programmed cell death protein 4 down-regulates Y-box binding protein-1 expression via a direct interaction with Twist1 to suppress cancer cell growth Cancer Res 69 2009 3148