Neuroprotective effect of neotrofin in a neonatal rat model of periventricular leukomalacia

Neuroscience Letters

Volumn 520, Issue 1, 2012, Pages 6-10

  Tüzün, Funda ^a   Gencpinar, Pinar ^a   özbal, Seda ^a   Dilek, Mustafa ^a   Ergur, Bekir Ugur ^a   Duman, Nuray ^a   Özkan, Hasan ^a   Kumral, Abdullah ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Hypomyelinization; Neotrofin; Newborn; Periventricular leukomalacia; Rat; White matter injury

Indexed keywords

CASPASE 3; ENDOTOXIN; LETEPRINIM; LIPOPOLYSACCHARIDE;

APOPTOSIS; ARTICLE; BRAIN INJURY; CELL DEATH; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; IMMUNOHISTOCHEMISTRY; LEUKOMALACIA; MYELINATION; NEUROPROTECTION; NEWBORN; NONHUMAN; PERINATAL PERIOD; PERIVENTRICULAR LEUKOMALACIA; POSTNATAL CARE; PRENATAL CARE; PRIORITY JOURNAL; RAT; WHITE MATTER INJURY;

AMINOBENZOIC ACIDS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BRAIN; CASPASE 3; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPOXANTHINES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFANT, NEWBORN; LEUKOMALACIA, PERIVENTRICULAR; LIPOPOLYSACCHARIDES; MATERNAL-FETAL EXCHANGE; MYELIN BASIC PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; PREGNANCY; RATS; RATS, WISTAR;

EID: 84862122431     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.04.076     Document Type: Article

References (24)

1. Back S.A., Riddle A., McClure M.M. Maturation-dependent vulnerability of perinatal white matter in premature birth. Stroke 2007, 38:724-730.
2. Bintner J.S., Rathbone M.P., Juurlink B.H.J. AIT-082, a hypoxanthine derivative, prevents much of the decrease in cerebellar neuron ATP following glutamate exposure. Society for Neuroscience Abstract 1999, 25:2131.
3. Caciagli F., Ciccarelli R., Di Iorio P., Ballerini P., Di Giulio C., Bruno V., Battaglia G., Rathbone M. The hypoxanthine derivative AIT-082 protects against neurotoxicity in vitro and in vivo. Society for Neuroscience Abstract 1998, 24:1941.
4. Caciagli R.C.F., Di Iorio P., Ballerini P., Di Giulio C., Bruno V., Battaglia G., Rathbone M.P. The hypoxanthine derivative AIT-082 protects against neurotoxicity in vitro and in vivo. Society for Neuroscience Abstract 1998, 24:1941.
5. Cai Z., Pan Z.L., Pang Y., Evans O.B., Rhodes P.G. Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration. Pediatric Research 2000, 47:64-72.
6. Chamnanvanakij S., Margraf L.R., Burns D., Perlman J.M. Apoptosis and white matter injury in preterm infants. Pediatric and Developmental Pathology 2002, 5:184-189.
7. Ciccarelli R. Guanosine and related drugs stimulate the production of neurotrophic factors from rat cultured astrocytes by involving mitogen-activated protein kinase pathway. Society for Neuroscience Abstract 1998, 25:1013.
8. Deng W., Pleasure J., Pleasure D. Progress in periventricular leukomalacia. Archives of Neurology 2008, 65:1291-1295.
9. Di Iorio P., Virgilio A., Giuliani P., Ballerini P., Vianale G., Middlemiss P.J., Rathbone M.P., Ciccarelli R. AIT-082 is neuroprotective against kainate-induced neuronal injury in rats. Experimental Neurology 2001, 169:392-399.
10. Follett P.L., Deng W., Dai W., Talos D.M., Massillon L.J., Rosenberg P.A., Volpe J.J., Jensen F.E. Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate. Journal of Neuroscience 2004, 24:4412-4420.
11. Gencpinar P., Tuzun F., Ozbal S., Tugyan K., Duman N., Ozkan H., Kumral A. Effects of neotrofin on neonatal hypoxic ischemic brain injury. Neuroscience Letters 2012, 505:205-210.
12. Glasky A.J., Melchior C.L., Pirzadeh B., Heydari N., Ritzmann R.F. Effect of AIT-082, a purine analog, on working memory in normal and aged mice. Pharmacology Biochemistry and Behavior 1994, 47:325-329.
13. Glasky M.S., Conner J.M., Tuszynski M.H. Oral administration of AIT-082 stimulates BDNF and NGF expression in vivo in rats. Society for Neuroscience Abstract 2001, 27:137-140.
14. Hefti F. Growth factors and neurodegeneration. Neurodegenerative Diseases 1994, 177-194. W.B. Saunders, Philadelphia, PA. D.B. Calne (Ed.).
15. Juurlik B.H.J., Rathbone M.P. The hypoxanthine derivative AIT-082 promotes neurite formation and regeneration in cultured hippocampal neurons. Society for Neuroscience Abstract 1998, 24:1941.
16. Kadhim H., Khalifa M., Deltenre P., Casimir G., Sebire G. Molecular mechanisms of cell death in periventricular leukomalacia. Neurology 2006, 67:293-299.
17. Kumral A., Baskin H., Yesilirmak D.C., Ergur B.U., Aykan S., Genc S., Genc K., Yilmaz O., Tugyan K., Giray O., Duman N., Ozkan H. Erythropoietin attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain. Neonatology 2007, 92:269-278.
18. Middlemiss P., Imitiaz M., Jiang S., Mintz A., Almas C., Crocker C., Virk T., Rathbone M.P. The synthetic purine AIT-082 enhances recovery after acute spinal cord crush injury in rats. Society for Neuroscience Abstract 1999, 25:1002.
19. Nakajima W., Ishida A., Lange M.S., Gabrielson K.L., Wilson M.A., Martin L.J., Blue M.E., Johnston M.V. Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat. Journal of Neuroscience 2000, 20:7994-8004.
20. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2002, Academic Press, New York.
21. Tuzun F., Kumral A., Dilek M., Ozbal S., Ergur B., Yesilirmak D.C., Duman N., Yilmaz O., Ozkan H. Maternal omega-3 fatty acid supplementation protects against lipopolysaccharide-induced white matter injury in the neonatal rat brain. Journal of Maternal-Fetal and Neonatal Medicine 2011, (Epub ahead of print). 10.3109/14767058.2011.587917.
22. Walters J., Pop C., Scott F.L., Drag M., Swartz P., Mattos C., Salvesen G.S., Clark A.C. A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochemical Journal 2009, 424:335-345.
23. Wang X., Hauptmann N., Taylor E., Foreman M., Khawli L.A., Maines M.D. Neotrofin increases heme oxygenase-1 selectively in neurons. Brain Research 2003, 962:1-14.
24. Webster N.J.G., Pirrung M.C. Small molecule activators of the Trk receptors for neuroprotection. BMC Neuroscience 2008, 9:1-8.