Evolutionary history of copy-number-variable locus for the low-affinity Fcγ receptor: Mutation rate, autoimmune disease, and the legacy of helminth infection

American Journal of Human Genetics

Volumn 90, Issue 6, 2012, Pages 973-985

  MacHado, Lee R ^a   Hardwick, Robert J ^a,d   Bowdrey, Jennifer ^a   Bogle, Helen ^a,e   Knowles, Timothy J ^b   Sironi, Manuela ^c   Hollox, Edward J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c SCIENTIFIC INSTITUTE   (Italy)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD16 ANTIGEN; FC RECEPTOR; FC RECEPTOR IIA; FC RECEPTOR IIB; FC RECEPTOR IIC; FCGAMMA RECEPTOR IIIA; FCGAMMA RECEPTOR IIIB; HUMAN NEUTROPHIL ANTIGEN 1; IMMUNOGLOBULIN G; LEUKOCYTE ANTIGEN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; GENE DELETION; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HELMINTHIASIS; HOMOLOGOUS RECOMBINATION; HUMAN; HYGIENE HYPOTHESIS; IMMUNOPATHOGENESIS; MOLECULAR EVOLUTION; MUTATION RATE; NONALLELIC HOMOLOGOUS RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

ALLELES; AUTOIMMUNE DISEASES; EVOLUTION, MOLECULAR; GENE DELETION; GENE DOSAGE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HAPLOTYPES; HELMINTHIASIS; HUMANS; IMMUNOGLOBULIN G; MODELS, GENETIC; MUTATION; MUTATION RATE; PHYLOGENY; RECEPTORS, IGG; RECOMBINATION, GENETIC;

MAMMALIA; VERMES;

EID: 84862119571     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2012.04.018     Document Type: Article

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