Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): Findings from a Contact Dermatitis Unit

Cutaneous and Ocular Toxicology

Volumn 31, Issue 2, 2012, Pages 151-153

  Maio, Paula ^a   Carvalho, Rodrigo ^a   Amaro, Cristina ^a   Santos, Raquel ^a   Cardoso, Jorge ^a  

^a HOSPITAL CURRY CABRAL   (Portugal)

Author keywords

contact dermatitis; MCI MI; methylchoroisothiazolinone; methylisothiazolinone; occupational; patch testing; Preservatives

Indexed keywords

2 METHYL 4 ISOTHIAZOLIN 3 ONE; 5 CHLORO 2 METHYL 4 ISOTHIAZOLIN 3 ONE; CHROMIUM; CONTACT ALLERGEN; FRAGRANCE; NICKEL;

ADULT; AGED; ARTICLE; ATOPY; CONTACT ALLERGY; CONTACT DERMATITIS; EUROPEAN UNION; FEMALE; HEAD AND NECK DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MORBIDITY; PATCH TEST; PERSONAL HYGIENE; RETROSPECTIVE STUDY;

ADULT; AGED; ALLERGENS; ANTI-INFECTIVE AGENTS; COSMETICS; DERMATITIS, ALLERGIC CONTACT; DERMATITIS, OCCUPATIONAL; FEMALE; HOSPITAL UNITS; HUMANS; MALE; MIDDLE AGED; PATCH TESTS; PRESERVATIVES, PHARMACEUTICAL; THIAZOLES;

EID: 84862100563     PISSN: 15569527     EISSN: 15569535     Source Type: Journal    
DOI: 10.3109/15569527.2011.627522     Document Type: Article

References (17)

1. Fransway Anthony. Sensitivity to Kathon®CG: findings in 365 patients. Contact Derm 1988:19:342-347.
2. Ledieu G., Martin P. et al. L'Allergie de Contact au Kathon®CG- A propos de 35 cas sur 977 sujects testés. Ann. Dermatol. Venereol. 1991,118:181-189.
3. de Groot AC, Liem DH, Weyland JW. Kathon CG: Cosmetic allergy and patch test sensitization. Contact Derm 1985;12:76-80.
4. Torén K, Brisman J, Meding B. Sensitization and exposure to methylisothiazolinones (Kathon) in the pulp and paper industry - report of two cases. Am J Ind Med 1997;31:551-553.
5. Belsito DV, Fowler JF Jr, Sasseville D, Marks JG Jr, De Leo VA, Storrs FJ. Delayed-type hypersensitivity to fragrance materials in a select North American population. Dermatitis 2006;17:23-28.
6. Jong CT, Statham BN, Green CM, King CM, Gawkrodger DJ, Sansom JE, English JSC, Wilkinson SM, Chowdhury MMU. Contact sensitivity to preservatives in the UK, 2004-2005: Results of multicenter study. Contact Dermatitis 2007; 46:207-210.
7. Maibach HI. Diagnostic patch test concentration for Kathon CG. Contact Derm 1985;13:242-245.
8. Wilkinson JD, Shaw S, Andersen KE, Brandao FM, Bruynzeel DP, Bruze M et al. Monitoring levels of preservative sensitivity in Europe. A 10-year overview (1991-2000). Contact Derm 2002;46:207-210.
9. Dstychová E., Necas M et al. Contact hypersensitivity to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema. Acta Dermatoven. 2008, APA (17) No2.
10. Fewings and Menné. An update on risk assessment for MCI/MI. Contact Derm 1999;41:1-13.
11. Menné T, Frosch P J, Veien N K et al. Contact sensitization to to 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (MCI/MI). A European multicenter study. Contact Derm 1991: 24: 334-341.
12. Hannuksela M. Rapid increase in contact allergy to Kathon CG in Finland. Contact Derm 1986;15:211-214.
13. MD Ludov, JP Thyssen, C Zachariae Prevalence and cause of methylisothiazolinone contact allergy. Contact Derm. 2010;63:164-167.
14. Wilkinson J D, Shaw S, Andersen K E, Brandao F M, Bruynzeel D P. Monitoring levels of preservative sensitivity in Europe. A 10-year overview (1991-2000). Contact Derm 2002:46:207-210.
15. Bruze M, Dahlquist I, Fregert S, Gruvberger B, Persson K. Contact allergy to the active ingredients of Kathon CG. Contact Derm 1987;16:183-188.
16. Bruze M, Dahlquist I, Gruvberger B. Contact allergy to dichlorinated methylisothiazolinone. Contact Derm 1989;20:219-220.
17. Isaksson M, Bruze M, Gruvberger B. Cross-reactivity between methylchloromethylisothiazolinone/methylisothiazolinone, and other isothiazolinones in workers at a plant producing binders for paints and glues. Contact Derm 2008;58:60-62.