Are all airways equal?

Journal of Applied Physiology

Volumn 112, Issue 9, 2012, Pages 1431-1432

  Winkler, Tilo ^a   Venegas, Jose G ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; DEXAMETHASONE; DIAGNOSTIC AGENT; HELIUM;

ANIMAL; ASTHMA; BREATHING MECHANICS; DRUG EFFECT; EDITORIAL; HYPERSENSITIVITY; LUNG; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING;

ADRENAL CORTEX HORMONES; ANIMALS; ASTHMA; DEXAMETHASONE; HELIUM; HYPERSENSITIVITY; LUNG; MAGNETIC RESONANCE IMAGING; MALE; RESPIRATORY MECHANICS;

EID: 84862100171     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00253.2012     Document Type: Editorial

References (15)

1. Altes TA, Powers PL, Knight-Scott J, Rakes G, Platts-Mills TA, de Lange EE, Alford BA, Mugler JP 3rd, Brookeman JR. Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findings. J Magn Reson Imaging 13: 378-384, 2001. (Pubitemid 32173404)
2. Ballester E, Reyes A, Roca J, Guitart R, Wagner PD, Rodriguez- Roisin R. Ventilation-perfusion mismatching in acute severe asthma: effects of salbutamol and 100% oxygen. Thorax 44: 258-267, 1989. (Pubitemid 19113526)
3. Bates JH, Cojocaru A, Haverkamp HC, Rinaldi LM, Irvin CG. The synergistic interactions of allergic lung inflammation and intratracheal cationic protein. Am J Respir Crit Care Med 177: 261-268, 2008. (Pubitemid 351198368)
4. Bayat S, Porra L, Suhonen H, Suortti P, Sovijarvi AR. Paradoxical conducting airway responses and heterogeneous regional ventilation after histamine inhalation in rabbit studied by synchrotron radiation CT. J Appl Physiol 106: 1949-1958, 2009.
5. Braune A, Venegas JG, Winkler T. Synergistic effects of airway wall thickening and smooth muscle stimulation in asthma. Am J Respir Crit Care Med 183: A2301, 2011.
6. Brown RH, Mitzner W. The myth of maximal airway responsiveness in vivo. J Appl Physiol 85: 2012-2017, 1998. (Pubitemid 28558053)
7. Fain SB, Gonzalez-Fernandez G, Peterson ET, Evans MD, Sorkness RL, Jarjour NN, Busse WW, Kuhlman JE. Evaluation of structurefunction relationships in asthma using multidetector CT and hyperpolarized He-3 MRI. Acad Radiol 15: 753-762, 2008. (Pubitemid 351662749)
8. Harris RS, Winkler T, Tgavalekos N, Musch G, Melo MF, Schroeder T, Chang Y, Venegas JG. Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma. Am J Respir Crit Care Med 174: 245-253, 2006. (Pubitemid 44156602)
9. Thomas AC, Kaushik SS, Nouls J, Potts EN, Slipetz DM, Foster WM, Driehuys B. Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized 3He magnetic resonance imaging in an allergic mouse model. J Appl Physiol; doi:101152/japplphysiol.01293.2011.
10. Tzeng YS, Lutchen K, Albert M. The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI. J Appl Physiol 106: 813-822, 2009.
11. Venegas JG, Schroeder T, Harris S, Winkler RT, Melo MF. The distribution of ventilation during bronchoconstriction is patchy and bimodal: a PET imaging study. Respir Physiol Neurobiol 148: 57-64, 2005. (Pubitemid 41132750)
12. Venegas JG, Winkler T, Musch G, Vidal Melo MF, Layfield D, Tgavalekos N, Fischman AJ, Callahan RJ, Bellani G, Harris RS. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature 434: 777-782, 2005. (Pubitemid 44739522)
13. Winkler T, Suki B. Emergent structure-function relations in emphysema and asthma. Crit Rev Biomed Eng 39: 263-280, 2011.
14. Winkler T, Venegas JG. Effects of tidal volume on spatial clustering of broncho-constriction. Am J Respir Crit Care Med 171: A565, 2005.
15. Winkler T, Venegas JG. Self-organized patterns of airway narrowing. J Appl Physiol 110: 1482-1486, 2011.