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Volumn 71, Issue , 2012, Pages 111-117

Design and operation of a filter reactor for continuous production of a selected pharmaceutical intermediate

Author keywords

Batch; Chemical reactors; Continuous design; Grignard; Optimization; Pharmaceuticals

Indexed keywords

BATCH REACTORS; CHEMICAL REACTORS; CHLORINE COMPOUNDS; DRUG PRODUCTS; OPTIMIZATION; ORGANIC SOLVENTS;

EID: 84855774460     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2011.12.002     Document Type: Article
Times cited : (21)

References (29)
  • 1
    • 79251504260 scopus 로고    scopus 로고
    • Current practices of process validation for drug substances and intermediates
    • Anderson N.G., Burdick D.C., Reeve M.M. Current practices of process validation for drug substances and intermediates. Org. Process Res. Dev. 2011, 15:162-172.
    • (2011) Org. Process Res. Dev. , vol.15 , pp. 162-172
    • Anderson, N.G.1    Burdick, D.C.2    Reeve, M.M.3
  • 2
    • 49149122787 scopus 로고    scopus 로고
    • Alternative to the microreactor
    • Ashe R. Alternative to the microreactor. Process Eng. 2008, 89:17-18.
    • (2008) Process Eng. , vol.89 , pp. 17-18
    • Ashe, R.1
  • 3
    • 84856587948 scopus 로고    scopus 로고
    • BASF Corporation, Tetrahydrofuran (THF) Storage and Handling. Material Safety Data Sheet. (retrieved 03/03/2010).
    • BASF Corporation, 1998. Tetrahydrofuran (THF) Storage and Handling. Material Safety Data Sheet. (retrieved 03/03/2010). http://www2.basf.us/diols/pdfs/thf_brochure.pdf.
    • (1998)
  • 4
  • 7
    • 63249085787 scopus 로고    scopus 로고
    • Quantifying experience in powder processing
    • Freeman T. Quantifying experience in powder processing. Pharm. Technol. Eur. 2009, 21:16-21.
    • (2009) Pharm. Technol. Eur. , vol.21 , pp. 16-21
    • Freeman, T.1
  • 8
    • 33749845639 scopus 로고    scopus 로고
    • Process development and production concepts for the manufacturing of organic fine chemicals at LONZA
    • Heckmann G., Previdoli F., Reidel T., Ruppen D., Veghini D., Zacher U. Process development and production concepts for the manufacturing of organic fine chemicals at LONZA. Chimia 2006, 60:530-533.
    • (2006) Chimia , vol.60 , pp. 530-533
    • Heckmann, G.1    Previdoli, F.2    Reidel, T.3    Ruppen, D.4    Veghini, D.5    Zacher, U.6
  • 9
    • 3042682174 scopus 로고    scopus 로고
    • Selectivity gains and energy savings for the industrial phenyl boronic acid process using micromixer/tubular reactors
    • Hessel V., Hofmann C., Löwe H., Meudt A., Scherer S., Schönfeld F., Werner B. Selectivity gains and energy savings for the industrial phenyl boronic acid process using micromixer/tubular reactors. Org. Process Res. Dev. 2004, 8:511-523.
    • (2004) Org. Process Res. Dev. , vol.8 , pp. 511-523
    • Hessel, V.1    Hofmann, C.2    Löwe, H.3    Meudt, A.4    Scherer, S.5    Schönfeld, F.6    Werner, B.7
  • 11
    • 84856584109 scopus 로고    scopus 로고
    • Reaktion von Carbonylverbindungen mit metallorganischen Reagenzien.
    • Merck Patent G.m.b.H., Germany DE 10001317.
    • Koop, U., Krummradt, H., Schwarz, M., Stoldt, J., Eckstein, J., Zehner, S., 2001. Reaktion von Carbonylverbindungen mit metallorganischen Reagenzien. Merck Patent G.m.b.H., Germany DE 10001317.
    • (2001)
    • Koop, U.1    Krummradt, H.2    Schwarz, M.3    Stoldt, J.4    Eckstein, J.5    Zehner, S.6
  • 12
    • 84856587951 scopus 로고    scopus 로고
    • Think small
    • Kossik J. Think small. Pharm. Manuf. 2002, 1:34-37.
    • (2002) Pharm. Manuf. , vol.1 , pp. 34-37
    • Kossik, J.1
  • 13
    • 33745266376 scopus 로고    scopus 로고
    • The microreactor a systematic and efficient tool for the transition from batch to continuous process?
    • Lomel S., Falk L., Commenge J.M., Houzelot J.L., Ramdani K. The microreactor a systematic and efficient tool for the transition from batch to continuous process?. Chem. Eng. Res. Des. 2006, 84:363-369.
    • (2006) Chem. Eng. Res. Des. , vol.84 , pp. 363-369
    • Lomel, S.1    Falk, L.2    Commenge, J.M.3    Houzelot, J.L.4    Ramdani, K.5
  • 14
    • 84856576962 scopus 로고    scopus 로고
    • (Food and Drug Administration), 2010. In: Proceedings of the ISPE Nordic Affiliate Conference on Continuous Manufacturing and PAT, Copenhagen, Handouts, 2 August
    • Moore, C. (Food and Drug Administration), 2010. In: Proceedings of the ISPE Nordic Affiliate Conference on Continuous Manufacturing and PAT, Copenhagen, Handouts, 2 August 2010.
    • (2010)
    • Moore, C.1
  • 15
    • 79551706348 scopus 로고    scopus 로고
    • Continuous oscillatory baffled reactor technology
    • Ni X. Continuous oscillatory baffled reactor technology. Innovations Pharm. Technol. 2006, 20:90-96.
    • (2006) Innovations Pharm. Technol. , vol.20 , pp. 90-96
    • Ni, X.1
  • 16
    • 84856584108 scopus 로고    scopus 로고
    • Novel Reactor Design for Organic-chemical Production of Pharmaceuticals.
    • M.Sc. Thesis. Department of Chemical and Biochemical Engineering, Technical University of Denmark.
    • Pedersen, M., 2009. Novel Reactor Design for Organic-chemical Production of Pharmaceuticals. M.Sc. Thesis. Department of Chemical and Biochemical Engineering, Technical University of Denmark.
    • (2009)
    • Pedersen, M.1
  • 17
    • 22744441634 scopus 로고    scopus 로고
    • Continuous processing in the pharmaceutical industry: changing the mind set
    • Plumb K. Continuous processing in the pharmaceutical industry: changing the mind set. Chem. Eng. Res. Des. 2005, 83:730-738.
    • (2005) Chem. Eng. Res. Des. , vol.83 , pp. 730-738
    • Plumb, K.1
  • 19
    • 77949915742 scopus 로고    scopus 로고
    • Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions
    • Riva E., Gagliardi S., Martinelli M., Passarella D., Vigo D., Rencurosi A. Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions. Tetrahedron 2010, 66:3242-3247.
    • (2010) Tetrahedron , vol.66 , pp. 3242-3247
    • Riva, E.1    Gagliardi, S.2    Martinelli, M.3    Passarella, D.4    Vigo, D.5    Rencurosi, A.6
  • 20
    • 15944366532 scopus 로고    scopus 로고
    • Microreactor technology: a revolution for the fine chemical and pharmaceutical industries?
    • Roberge D.M., Ducry L., Bieler N., Cretton P., Zimmermann B. Microreactor technology: a revolution for the fine chemical and pharmaceutical industries?. Chem. Eng. Technol. 2005, 28:318-323.
    • (2005) Chem. Eng. Technol. , vol.28 , pp. 318-323
    • Roberge, D.M.1    Ducry, L.2    Bieler, N.3    Cretton, P.4    Zimmermann, B.5
  • 21
    • 58149114898 scopus 로고    scopus 로고
    • Microreactor technology and continuous processes in the fine chemical and pharmaceutical industry: is the revolution underway?
    • Roberge D.M., Zimmermann B., Rainone F., Gottsponer M., Eyholzer M., Kockmann N. Microreactor technology and continuous processes in the fine chemical and pharmaceutical industry: is the revolution underway?. Org. Process Res. Dev. 2008, 12:905-910.
    • (2008) Org. Process Res. Dev. , vol.12 , pp. 905-910
    • Roberge, D.M.1    Zimmermann, B.2    Rainone, F.3    Gottsponer, M.4    Eyholzer, M.5    Kockmann, N.6
  • 24
    • 84856581950 scopus 로고    scopus 로고
    • Norvatis, MIT pair to improve drugmaking
    • (1 p.)
    • Swichtenberg B. Norvatis, MIT pair to improve drugmaking. Pharm. Manuf. 2007, 6:11. (1 p.).
    • (2007) Pharm. Manuf. , vol.6 , pp. 11
    • Swichtenberg, B.1
  • 25
    • 72449200368 scopus 로고    scopus 로고
    • Moving beyond the batch
    • Swichtenberg B. Moving beyond the batch. Pharm. Manuf. 2008, 7:24-26.
    • (2008) Pharm. Manuf. , vol.7 , pp. 24-26
    • Swichtenberg, B.1
  • 26
    • 84856587950 scopus 로고    scopus 로고
    • The reality of small scale continuous processes.
    • In: Proceedings of the Switching from Batch to Continuous Processing Conference. IChemE, London, 22-23 November 2004
    • Thomas, H., 2004. The reality of small scale continuous processes. In: Proceedings of the Switching from Batch to Continuous Processing Conference. IChemE, London, 22-23 November 2004.
    • (2004)
    • Thomas, H.1
  • 27
    • 33745210137 scopus 로고    scopus 로고
    • Evolving concepts in OSF plant design: part 2
    • Vu J., Lhoest W. Evolving concepts in OSF plant design: part 2. Pharm. Technol. Eur. 2006, 18:1-7.
    • (2006) Pharm. Technol. Eur. , vol.18 , pp. 1-7
    • Vu, J.1    Lhoest, W.2
  • 28
    • 0037704669 scopus 로고    scopus 로고
    • Continuous flow reactors for drug discovery
    • Watts P., Haswell S.J. Continuous flow reactors for drug discovery. Drug Discovery Today 2003, 8:586-593.
    • (2003) Drug Discovery Today , vol.8 , pp. 586-593
    • Watts, P.1    Haswell, S.J.2
  • 29
    • 53749090735 scopus 로고    scopus 로고
    • Continuous flow reactors, a tool for the modern synthetic chemist
    • Wiles C., Watts P. Continuous flow reactors, a tool for the modern synthetic chemist. Eur. J. Org. Chem. 2008, 2008:1655-1671.
    • (2008) Eur. J. Org. Chem. , vol.2008 , pp. 1655-1671
    • Wiles, C.1    Watts, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.