Stereoselective synthesis of (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl) propanenitrile

Journal of Organic Chemistry

Volumn 77, Issue 10, 2012, Pages 4732-4739

  Lall, Manjinder S ^a   Hoge, Garrett ^b   Tran, Tuan P ^a   Kissel, William ^c   Murphy, Sean T ^d   Taylor, Clarke ^e   Hutchings, Kim ^f   Samas, Brian ^a   Ellsworth, Edmund L ^a   Curran, Timothy ^g   Showalter, H D Hollis ^h  

^a PFIZER INC   (United States)

^b Dr Reddy's   (United Kingdom)

^c Ironwood Pharmaceuticals   (United States)

^d Takeda San Diego Inc   (United States)

^e Lycera Corporation   (United States)

^f ASTRAZENECA   (United Kingdom)

^g VERTEX PHARMACEUTICALS   (United States)

^h UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC HYDROGENATION; EXTRACTION PROTOCOLS; FLUOROQUINOLONE ANTIBIOTICS; HIGH YIELD; INVERSION OF CONFIGURATION; RESPIRATORY TRACT INFECTIONS; STEREOSELECTIVE SYNTHESIS; SYNTHETIC SEQUENCE;

AMIDES; CHLORINE COMPOUNDS; HYDROGENATION; STEREOCHEMISTRY; SUBSTITUTION REACTIONS;

STEREOSELECTIVITY;

3 (METHYLAMINO) 3 (PYRROLIDIN 3 YL)PROPANENITRILE DERIVATIVE; AMIDE; BENZYL DERIVATIVE; BENZYLOXYACETYL CHLORIDE; METHYLAMINE; NITRILE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; CRYSTALLIZATION; EXTRACTION; HYDROGENATION; STEREOCHEMISTRY; SUBSTITUTION REACTION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; CATALYSIS; FLUOROQUINOLONES; MOLECULAR STRUCTURE; NITRILES; PYRROLIDINES; STEREOISOMERISM;

EID: 84862076455     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo3004716     Document Type: Article

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