Is hepatitis C virus core antigen an adequate marker for community screening?

Journal of Clinical Microbiology

Volumn 50, Issue 6, 2012, Pages 1989-1993

  Kuo, Yuan Hung ^a   Chang, Kuo Chin ^a   Wang, Jing Houng ^a   Tsai, Pei Shan ^a   Hung, Shu Feng ^a   Hung, Chao ^a   Chen, Chien Hung ^a   Lu, Sheng Nan ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS C ANTIBODY; HEPATITIS C ANTIGEN; HEPATITIS C CORE ANTIGEN; UNCLASSIFIED DRUG; VIRUS RNA;

ACCURACY; ADULT; AGED; ARTICLE; COMMUNITY ASSESSMENT; CORRELATION ANALYSIS; ENDEMIC DISEASE; FEMALE; FOLLOW UP; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS SCREENING; PREDICTIVE VALIDITY; PREDICTIVE VALUE; PRIORITY JOURNAL; RESIDENTIAL AREA; RNA ANALYSIS; SENSITIVITY AND SPECIFICITY; VIREMIA;

AGED; AGED, 80 AND OVER; CLINICAL LABORATORY TECHNIQUES; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIBODIES; HEPATITIS C ANTIGENS; HUMANS; MALE; MASS SCREENING; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; VIRAL CORE PROTEINS; VIROLOGY;

HEPATITIS C VIRUS;

EID: 84862075103     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.05175-11     Document Type: Article

References (28)

1. Centers for Disease Control and Prevention. Hepatitis C information for health professionals: laboratory testing. Centers for Disease Control and Prevention, Atlanta, GA. http://www.cdc.gov/hepatitis/HCV/LabTesting.htm.
2. Enomoto M, et al. 2005. Chemiluminescence enzyme immunoassay for monitoring hepatitis C virus core protein during interferon-alpha 2b and ribavirin therapy in patients with genotype 1 and high viral loads. J. Med. Virol. 77:77-82.
3. Fabrizi F, et al. 2005. Novel assay using total hepatitis C virus (HCV) core antigen quantification for diagnosis of HCV infection in dialysis patients. J. Clin. Microbiol. 43:414-420.
4. Hayashi K, et al. 2005. Usefulness of a new immuno-radiometric assay to detect hepatitis C core antigen in a community-based population. J. Viral Hepat. 12:106-110. (Pubitemid 40188783)
5. Huang WS, et al. 2005. Prediction of viremia for cases of hepatitis C virus (HCV) infection using a third-generation anti-HCV enzyme immunoassay test. Hepatogastroenterology 52:893-896.
6. Huang YC, et al. 2011. Community-based screening for hepatocellular carcinoma in elderly residents in a hepatitis B- and C-endemic area. J. Gastroenterol. Hepatol. 26:129-134.
7. Hung CH, et al. 2008. Identified cases of acute hepatitis C from computerized laboratory database: a hospital-based epidemiological and clinical study. J. Infect. 56:274-280.
8. Kaiser T, et al. 2008. Kinetics of hepatitis C viral RNA and HCV-antigen during dialysis sessions: evidence for differential viral load reduction on dialysis. J. Med. Virol. 80:1195-1201. (Pubitemid 351705998)
9. Lavanchy D. 2009. The global burden of hepatitis C. Liver Int. 29(Suppl. 1):74-81.
10. Lu SN, et al. 2003. Molecular epidemiological and clinical aspects of hepatitis D virus in a unique triple hepatitis viruses (B, C, D) endemic community in Taiwan. J. Med. Virol. 70:74-80.
11. Lu SN, et al. 1997. Different viral aetiology of hepatocellular carcinoma between two hepatitis B and C endemic townships in Taiwan. J. Gastroenterol. Hepatol. 12:547-550.
12. Lu SN, et al. 2004. Is it possible to diagnose acute hepatitis C virus (HCV) infection by a rising anti-HCV titre rather than by seroconversion? J. Viral Hepat. 11:563-570.
13. Maillard P, et al. 2001. Nonenveloped nucleocapsids of hepatitis C virus in the serum of infected patients. J. Virol. 75:8240-8250. (Pubitemid 32743696)
14. Miedouge M, Saune K, Kamar N, Rieu M. 2010. Analytical evaluation of HCV core antigen and interest for HCV screening in haemodialysis patients. J. Clin. Virol. 48:18-21.
15. Morota K, et al. 2009. A new sensitive and automated chemiluminescent microparticle immunoassay for quantitative determination of hepatitis C virus core antigen. J. Virol. Methods 157:8-14.
16. National Institutes of Health. 2002. NIH consensus statement on management of hepatitis C. NIH Consens. State Sci. Statements 19:1-46.
17. Park Y, et al. 2010. New automated hepatitis C virus (HCV) core antigen assay as an alternative to real-time PCR for HCV RNA quantification. J. Clin. Microbiol. 48:2253-2256.
18. Richter SS. 2002. Laboratory assays for diagnosis and management of hepatitis C virus infection. J. Clin. Microbiol. 40:4407-4412. (Pubitemid 35434922)
19. Ross RS, et al. 2010. Analytical performance characteristics and clinical utility of a novel assay for total hepatitis C virus core antigen quantification. J. Clin. Microbiol. 48:1161-1168.
20. Schüttler CG, et al. 2004. Variable v ratio of hepatitis C virus RNA to viral core antigen in patient sera. J. Clin. Microbiol. 42:1977-1981. (Pubitemid 38637810)
21. Seme K, Poljak M, Babic DZ, Mocilnik T, Vince A. 2005. The role of core antigen detection in management of hepatitis C: a critical review. J. Clin. Virol. 32:92-101. (Pubitemid 40093959)
22. Shepard CW, Finelli L, Alter MJ. 2005. Global epidemiology of hepatitis C virus infection. Lancet Infect. Dis. 5:558-567. (Pubitemid 41196755)
23. Singal AK, et al. 2010. Antiviral therapy reduces risk of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis. Clin. Gastroenterol. Hepatol. 8:192-199.
24. Sroczynski G, et al. 2009. Long-term effectiveness and cost-effectiveness of screening for hepatitis C virus infection. Eur. J. Public Health 19:245-253.
25. Tanaka E, et al. 2000. Evaluation of a new enzyme immunoassay for hepatitis C virus (HCV) core antigen with clinical sensitivity approximating that of genomic amplification of HCV RNA. Hepatology 32:388-393. (Pubitemid 30614672)
26. Tsai PS, et al. 2011. Acquirement and disappearance of HBsAg and anti-HCV in an aged population: a follow-up study in an endemic town-ship. Liver Int. 31:971-979.
27. Wang JH, et al. 2010. Liver stiffness decrease after effective antiviral therapy in patients with chronic hepatitis C: longitudinal study using FibroScan. J. Gastroenterol. Hepatol. 25:964-969.
28. Zanetti AR, et al. 2003. Total HCV core antigen assay: a new marker of hepatitis C viremia for monitoring the progress of therapy. J. Med. Virol. 70:27-30. (Pubitemid 36368861)