Convergent, kilogram scale synthesis of an Akt kinase inhibitor

Organic Process Research and Development

Volumn 16, Issue 5, 2012, Pages 1069-1081

  Grongsaard, Pintipa ^a   Bulger, Paul G ^a   Wallace, Debra J ^a   Tan, Lushi ^a   Chen, Qinghao ^a   Dolman, Sarah J ^a   Nyrop, Jason ^a   Hoerrner, R Scott ^a   Weisel, Mark ^a   Arredondo, Juan ^a   Itoh, Takahiro ^a   Xie, Chengfu ^b   Wen, Xianghui ^b   Zhao, Dalian ^a   Muzzio, Daniel J ^a   Bassan, Ephraim M ^a   Shultz, C Scott ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b WUXI APPTEC   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOSELECTIVE; CHROMATOGRAPHY-FREE SYNTHESIS; CONTINUOUS PROCESSING; CYCLOBUTANES; DIANIONS; DIASTEREOMERS; ESTER HYDROLYSIS; FORMYLATION; FRAGMENT COUPLING; HIGH TEMPERATURE AND PRESSURE; KINASE INHIBITORS; PROCESS DEVELOPMENT; REACTION YIELDS; TARGET MOLECULE;

BUTANE; LITHIUM;

CHROMATOGRAPHY;

EID: 84862070513     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op300031r     Document Type: Article

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