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Volumn 9, Issue 7, 2010, Pages 504-506

Allosteric AKT inhibitors as a targeted cancer therapy

Author keywords

Allosteric AKT inhibitor; Dose schedules; Hyperglycemia; Insulin resistance; Pharmacodynamics; Pharmacokinetics; PI3K AKT signaling pathway

Indexed keywords

PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR;

EID: 77953699532     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.9.7.11356     Document Type: Note
Times cited : (10)

References (24)
  • 2
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2:489-501. (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 5
    • 54949109808 scopus 로고    scopus 로고
    • PI3K/Akt: Getting it right matters
    • Franke TF. PI3K/Akt: getting it right matters. Oncogene 2008; 27:6473-88.
    • (2008) Oncogene , vol.27 , pp. 6473-6488
    • Franke, T.F.1
  • 7
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005; 5:341-54.
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 9
    • 39049171769 scopus 로고    scopus 로고
    • The PI3K/Akt pathway: Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors
    • Lindsley CW, Barnett SF, Layton ME, Bilodeau MT. The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors. Curr Cancer Drug Targets 2008; 8:7-18.
    • (2008) Curr Cancer Drug Targets , vol.8 , pp. 7-18
    • Lindsley, C.W.1    Barnett, S.F.2    Layton, M.E.3    Bilodeau, M.T.4
  • 10
    • 34547817154 scopus 로고    scopus 로고
    • A new paradigm for protein kinase inhibition: Blocking phosphorylation without directly targeting ATP binding
    • Bogoyevitch MA, Fairlie DP. A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding. Drug Discov Today 2007; 12:622-33.
    • (2007) Drug Discov Today , vol.12 , pp. 622-633
    • Bogoyevitch, M.A.1    Fairlie, D.P.2
  • 13
    • 52449092107 scopus 로고    scopus 로고
    • Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling
    • She QB, Chandarlapaty S, Ye Q, Lobo J, Haskell KM, Leander KR, et al. Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. PLoS One 2008; 3:3065.
    • (2008) PLoS One , vol.3 , pp. 3065
    • She, Q.B.1    Chandarlapaty, S.2    Ye, Q.3    Lobo, J.4    Haskell, K.M.5    Leander, K.R.6
  • 14
    • 77953721226 scopus 로고    scopus 로고
    • An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transietn effects on glucose and insulin levels in vivo
    • Cherrin C, Haskell K, Howell B, Jones R, Leander K, Robinson R, et al. An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transietn effects on glucose and insulin levels in vivo. Cancer Biol Ther 2010; 9:493-503.
    • (2010) Cancer Biol Ther , vol.9 , pp. 493-503
    • Cherrin, C.1    Haskell, K.2    Howell, B.3    Jones, R.4    Leander, K.5    Robinson, R.6
  • 15
    • 34547933680 scopus 로고    scopus 로고
    • Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition
    • Han EK, Leverson JD, McGonigal T, Shah OJ, Woods KW, Hunter T, et al. Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. Oncogene 2007; 26:5655-61.
    • (2007) Oncogene , vol.26 , pp. 5655-5661
    • Han, E.K.1    Leverson, J.D.2    McGonigal, T.3    Shah, O.J.4    Woods, K.W.5    Hunter, T.6
  • 16
    • 42049115641 scopus 로고    scopus 로고
    • Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity
    • Rhodes N, Heerding DA, Duckett DR, Eberwein DJ, Knick VB, Lansing TJ, et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res 2008; 68:2366-74.
    • (2008) Cancer Res , vol.68 , pp. 2366-2374
    • Rhodes, N.1    Heerding, D.A.2    Duckett, D.R.3    Eberwein, D.J.4    Knick, V.B.5    Lansing, T.J.6
  • 17
    • 20344384859 scopus 로고    scopus 로고
    • Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo
    • Luo Y, Shoemaker AR, Liu X, Woods KW, Thomas SA, de Jong R, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther 2005; 4:977-86.
    • (2005) Mol Cancer Ther , vol.4 , pp. 977-986
    • Luo, Y.1    Shoemaker, A.R.2    Liu, X.3    Woods, K.W.4    Thomas, S.A.5    De Jong, R.6
  • 19
    • 85047693348 scopus 로고    scopus 로고
    • Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBbeta
    • Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, et al. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBbeta. J Clin Invest 2003; 112:197-208.
    • (2003) J Clin Invest , vol.112 , pp. 197-208
    • Garofalo, R.S.1    Orena, S.J.2    Rafidi, K.3    Torchia, A.J.4    Stock, J.L.5    Hildebrandt, A.L.6
  • 20
    • 73349099049 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
    • Tolcher AW, Sarantopoulos J, Patnaik A, Papadopoulos K, Lin CC, Rodon J, et al. Phase I, pharmacokinetic and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol 2009; 27:5800-7.
    • (2009) J Clin Oncol , vol.27 , pp. 5800-5807
    • Tolcher, A.W.1    Sarantopoulos, J.2    Patnaik, A.3    Papadopoulos, K.4    Lin, C.C.5    Rodon, J.6
  • 21
    • 59649123810 scopus 로고    scopus 로고
    • Integrating BRAF/MEK inhibitors into combination therapy for melanoma
    • Smalley KS, Flaherty KT. Integrating BRAF/MEK inhibitors into combination therapy for melanoma. Br J Cancer 2009; 100:431-5.
    • (2009) Br J Cancer , vol.100 , pp. 431-435
    • Smalley, K.S.1    Flaherty, K.T.2
  • 22
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007; 6:273-86.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.