Transcriptional regulation of platelet-derived growth factor-B chain by thrombin in endothelial cells: Involvement of Egr-1 and CREB-binding protein

Molecular and Cellular Biochemistry

Volumn 366, Issue 1-2, 2012, Pages 81-87

  Chen, Jing ^a   Xu, Lin ^a   Chen, Sisi ^a   Yang, Jian ^a   Jiang, Hong ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

CREB binding protein; Early growth response 1; Endothelial cell; Platelet derived growth factor B; Thrombin

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SMALL INTERFERING RNA; THROMBIN; TRANSCRIPTION FACTOR EGR 1;

ADENOVIRUS INFECTION; ANIMAL CELL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; NONHUMAN; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THORACIC AORTA; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; AORTA, THORACIC; CELLS, CULTURED; CREB-BINDING PROTEIN; EARLY GROWTH RESPONSE PROTEIN 1; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; MALE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-SIS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; THROMBIN; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84862018724     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1285-z     Document Type: Article

References (32)

1. Ferns GA, Raines EW, Sprugel KH, Motani AS, Reidy MA, RossR (1991) Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science 253:1129-1132 (Pubitemid 21917260)
2. Ross R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362:801-809
3. Deguchi J, Namba T, Hamada H, Nakaoka T, Abe J, Sato O, Miyata T, Makuuchi M, Kurokawa K, Takuwa Y (1999) Targeting endogenous platelet-derived growth factor B-chain by adenovirus-mediated gene transfer potently inhibits in vivo smooth muscle proliferation after arterial injury. Gene Ther 6:956-965 (Pubitemid 29295200)
4. Harlan JM, Thompson PJ, Ross RR, Bowen-Pope DF (1986) Alpha-thrombin induces release of platelet-derived growth factorlike molecule(s) by cultured human endothelial cells. J Cell Biol 103:1129-1133 (Pubitemid 17177359)
5. Deguchi J, Makuuchi M, Nakaoka T, Collins T, Takuwa Y (1999) Angiotensin II stimulates platelet-derived growth factor-B chain expression in newborn rat vascular smooth muscle cells and neointimal cells through Ras, extracellular signal-regulated protein kinase, and c-Jun N-terminal protein kinase mechanisms. Circ Res 85:565-574 (Pubitemid 29467845)
6. Ross R, Masuda J, Raines EW, Gown AM, Katsuda S, Sasahara M, Malden LT, Masuko H, Sato H (1990) Localization of PDGFB protein in macrophages in all phases of atherogenesis. Science 248:1009-1012
7. Nykänen AI, Krebs R, Tikkanen JM, Raisky O, Sihvola R, Wood J, Koskinen PK, Lemström KB (2005) Combined vascular endothelial growth factor and platelet-derived growth factor inhibition in rat cardiac allografts: beneficial effects on inflammation and smooth muscle cell proliferation. Transplantation 79:182-189
8. Kozaki K, Kaminski WE, Tang J, Hollenbach S, Lindahl P, Sullivan C, Yu JC, Abe K, Martin PJ, Ross R, Betsholtz C, Giese NA, Raines EW (2002) Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice. Am J Pathol 161:1395-1407
9. Scarpati EM, DiCorleto PE (1996) Identification of a thrombin response element in the human platelet-derived growth factor B-chain (c-sis) promoter. J Biol Chem 271:3025-3032
10. Shankar R, de la Motte CA, Poptic EJ, DiCorleto PE (1994) Thrombin receptor-activating peptides differentially stimulate platelet-derived growth factor production, monocytic cell adhesion, and E-selectin expression in human umbilical vein endothelial cells. J Biol Chem 269:13936-13941
11. Khachigian LM (2006) Early growth response-1 in cardiovascular pathobiology. Circ Res 98:186-191
12. Abdel-Malak NA, Mofarrahi M, Mayaki D, Khachigian LM, Hussain SN (2009) Early growth response-1 regulates angiopoietin- 1-induced endothelial cell proliferation, migration, and differentiation. Arterioscler Thromb Vasc Biol 29:209-216
13. Tsai JC, Liu L, Guan J, Aird WC (2000) The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells. Am J Physiol Cell Physiol 279:C1414-C1424
14. Khachigian LM, Anderson KR, Halnon NJ, Gimbrone MA Jr, Resnick N, Collins T (1997) Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shearstress- response element in the PDGF A-chain promoter. Arterioscler Thromb Vasc Biol 17:2280-2286 (Pubitemid 28057133)
15. Wu SQ, Minami T, Donovan DJ, Aird WC (2002) The proximal serum response element in the Egr-1 promoter mediates response to thrombin in primary human endothelial cells. Blood 100:4454-4461 (Pubitemid 35429685)
16. Khachigian LM, Lindner V, Williams AJ, Collins T (1996) Egr- 1-induced endothelial gene expression: a common theme in vascular injury. Science 271:1427-1431 (Pubitemid 26089480)
17. McCaffrey TA, Fu C, Du B, Eksinar S, Kent KC, Bush H Jr, Kreiger K, Rosengart T, Cybulsky MI, Silverman ES, Collins T (2000) High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis. J Clin Invest 105:653-662 (Pubitemid 30146512)
18. Mechtcheriakova D, Wlachos A, Holzmüller H, Binder BR, Hofer E (1999) Vascular endothelial cell growth factor-induced tissue factor expression in endothelial cells is mediated by EGR-1. Blood 93:3811-3823 (Pubitemid 29249828)
19. Hogan PG, Chen L, Nardone J, Rao A (2003) Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 17:2205-2232 (Pubitemid 37128637)
20. Khachigian LM, Williams AJ, Collins T (1995) Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells. J Biol Chem 270:27679-27686
21. Lucerna M, Mechtcheriakova D, Kadl A, Schabbauer G, Schäfer R, Gruber F, Koshelnick Y, Müller HD, Issbrücker K, Clauss M, Binder BR, Hofer E (2003) NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. J Biol Chem 278:11433-11440 (Pubitemid 36792702)
22. Silverman ES, Du J, Williams AJ, Wadgaonkar R, Drazen JM, Collins T (1998) cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1). Biochem J 336:183-189 (Pubitemid 28532575)
23. Suschek C, Kolb H, Kolb-Bachofen V (1997) Dobesilate enhances endothelial nitric oxide synthase-activity in macro- and microvascular endothelial cells. Br J Pharmacol 122:1502-1508 (Pubitemid 27503945)
24. Hoffmann J, Haendeler J, Aicher A, Rössig L, Vasa M, Zeiher AM, Dimmeler S (2001) Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. Circ Res 89:709-715 (Pubitemid 34627071)
25. Chen J, Jiang H, Xu L, Zhu LH, Wang L, Wen HZ, Hu XR (2008) Dysregulation of CREB binding protein triggers thrombininduced proliferation of vascular smooth muscle cells. Mol Cell Biochem 315:123-130
26. Borrelli V, Sterpetti AV, Coluccia P, Randone B, Cavallaro A, Santoro D'Angelo L, Cucina A (2001) Bimodal concentrationdependent effect of thrombin on endothelial cell proliferation and growth factor release in culture. J Surg Res 100:154-160 (Pubitemid 32989355)
27. Kamimura M, Bea F, Akizawa T, Katus HA, Kreuzer J, Viedt C (2004) Platelet-derived growth factor induces tissue factor expression in vascular smooth muscle cells via activation of Egr-1. Hypertension 44:944-951 (Pubitemid 39577426)
28. Kanda Y, Nishio E, Kuroki Y, Mizuno K, Watanabe Y (2001) Thrombin activates p38 mitogen-activated protein kinase in vascular smooth muscle cells. Life Sci 68:1989-2000 (Pubitemid 32245600)
29. Lee HM, Lee CK, Lee SH, Roh HY, Bae YM, Lee KY, Lim J, Park PJ, Park TK, Lee YL, Won KJ, Kim B (2007) p38 mitogenactivated protein kinase contributes to angiotensin II-stimulated migration of rat aortic smooth muscle cells. J Pharmacol Sci 105:74-81 (Pubitemid 47463527)
30. Vendrov AE, Madamanchi NR, Hakim ZS, Rojas M, Runge MS (2006) Thrombin and NAD(P)H oxidase-mediated regulation of CD44 and BMP4-Id pathway in VSMC, restenosis, and atherosclerosis. Circ Res 98:1254-1263 (Pubitemid 43948080)
31. Campos AH, Zhao Y, Pollman MJ, Gibbons GH (2003) DNA microarray profiling to identify angiotensin-responsive genes in vascular smooth muscle cells: potential mediators of vascular disease. Circ Res 92:111-118 (Pubitemid 36105614)
32. Vo N, Goodman RH (2001) CREB-binding protein and p300 in transcriptional regulation. J Biol Chem 276:13505-13508