Treatment-responsive pandysautonomia in an adolescent with ganglionic α3-AChR antibodies

European Journal of Paediatric Neurology

Volumn 16, Issue 4, 2012, Pages 396-398

  Dale, Russell C ^a   Lang, Bethan ^b   Brilot, Fabienne ^a   Polfrit, Yann ^c   Smith, Grahame H H ^d   Wong, Melanie ^d  

^a UNIVERSITY OF SYDNEY   (Australia)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c CHT Magenta   (New Caledonia)

^d CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

Author keywords

Autoantibody; Ganglionopathy; Pseudo obstruction; Pupillary dilatation; SLE

Indexed keywords

ALPHA3 CHOLINERGIC RECEPTOR ANTIBODY; ANTINUCLEAR ANTIBODY; AZATHIOPRINE; CALCIUM; CHOLINERGIC RECEPTOR ANTIBODY; COMPLEMENT COMPONENT C4; CREATININE; DOUBLE STRANDED DNA ANTIBODY; LISINOPRIL; PREDNISOLONE; UNCLASSIFIED DRUG; VITAMIN D;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADD ON THERAPY; ADOLESCENT; ARTICLE; ATROPHY; CASE REPORT; DECREASED APPETITE; DIARRHEA; DRUG DOSE INCREASE; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; HYDRONEPHROSIS; HYPOTENSION; IMMUNOSUPPRESSIVE TREATMENT; INTERSTITIAL NEPHRITIS; KIDNEY BIOPSY; NEUROLOGIC DISEASE; PANDYSAUTONOMIA; PRIORITY JOURNAL; PROTEINURIA; PSEUDOOBSTRUCTION; TREATMENT RESPONSE; TUBULAR ATROPHY; VISUAL DISORDER; VITAMIN SUPPLEMENTATION; VOMITING;

ABDOMINAL PAIN; ADOLESCENT; ANTI-INFLAMMATORY AGENTS; ANTIBODIES; AUTOIMMUNE DISEASES; AUTONOMIC NERVOUS SYSTEM DISEASES; AZATHIOPRINE; BICYCLO COMPOUNDS, HETEROCYCLIC; FEMALE; GANGLIA, AUTONOMIC; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL OBSTRUCTION; NICOTINIC AGONISTS; PREDNISOLONE; PYRIDINES; RADIOPHARMACEUTICALS; RECEPTORS, NICOTINIC;

EID: 84862007189     PISSN: 10903798     EISSN: 15322130     Source Type: Journal    
DOI: 10.1016/j.ejpn.2011.11.001     Document Type: Article

References (15)

1. N. Winston, and S. Vernino Recent advances in autoimmune autonomic ganglionopathy Curr Opin Neurol 23 2010 514 518
2. W. Xu, S. Gelber, and A. Orr-Urtreger Megacystis, mydriasis, and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor Proc Natl Acad Sci USA 96 1999 5746 5751
3. S. Vernino, P.A. Low, R.D. Fealey, J.D. Stewart, G. Farrugia, and V.A. Lennon Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies N Engl J Med 343 2000 847 855
4. S. Vernino, J. Lindstrom, S. Hopkins, Z. Wang, and P.A. Low Characterization of ganglionic acetylcholine receptor autoantibodies J Neuroimmunol 197 2008 63 69
5. S. Vernino Neuronal acetylcholine receptor autoimmunity Ann N Y Acad Sci 1132 2008 124 128
6. C.H. Ding, X.H. Wang, and L.P. Zou Clinical characteristics and diagnosis of acute pandysautonomia in childhood Zhonghua Er Ke Za Zhi 48 6 2010 454 459
7. P. Sandroni, S. Vernino, and C.M. Klein Idiopathic autonomic neuropathy: comparison of cases seropositive and seronegative for ganglionic acetylcholine receptor antibody Arch Neurol 61 2004 44 48
8. V. Iodice, K. Kimpinski, S. Vernino, P. Sandroni, R.D. Fealey, and P.A. Low Efficacy of immunotherapy in seropositive and seronegative putative autoimmune autonomic ganglionopathy Neurology 72 2009 2002 2008
9. C. Schroeder, S. Vernino, and A.L. Birkenfeld Plasma exchange for primary autoimmune autonomic failure N Engl J Med 353 2005 1585 1590
10. R. Imrich, S. Vernino, B.A. Eldadah, C. Holmes, and D.S. Goldstein Autoimmune autonomic ganglionopathy: treatment by plasma exchanges and rituximab Clin Auton Res 19 2009 259 262
11. A. McKeon, V.A. Lennon, D.H. Lachance, R.D. Fealey, and S.J. Pittock Ganglionic acetylcholine receptor autoantibody: oncological, neurological, and serological accompaniments Arch Neurol 66 2009 735 741
12. V.A. Lennon, L.G. Ermilov, J.H. Szurszewski, and S. Vernino Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease J Clin Invest 111 2003 907 913
13. S. Vernino, L.G. Ermilov, L. Sha, J.H. Szurszewski, P.A. Low, and V.A. Lennon Passive transfer of autoimmune autonomic neuropathy to mice J Neurosci 24 2004 7037 7042
14. Z. Wang, P.A. Low, and J. Jordan Autoimmune autonomic ganglionopathy: IgG effects on ganglionic acetylcholine receptor current Neurology 68 2007 1917 1921
15. Z. Wang, P.A. Low, and S. Vernino Antibody-mediated impairment and homeostatic plasticity of autonomic ganglionic synaptic transmission Exp Neurol 222 1 2010 114 119