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Management of hepatitis C genotype 4: Recommendations of an international expert panel
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Boceprevir and telaprevir in the management of hepatitis C virus-infected patients
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Butt, A.A.1
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Interferon lambdas: The next cytokines storm
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The era of direct-acting antivirals has begun: The beginning of the end for HCV?
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PSI-7851, a pronucleotide of β-D-2′-deoxy-2′-fluoro- 2′-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication
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Lam AM, Murakami E, Espiritu C, Steuer HM et al. PSI-7851, a pronucleotide of β-D-2′-deoxy-2′-fluoro-2′-C- methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob. Agents Chemother. 54(8), 3187-3196 (2010).
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New NS5B polymerase inhibitors for hepatitis C
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Review of NS5B nucleos(t)ide and non-nucleoside inhibitors published in 2010 and before. Includes a comparison of the differences between the two classes
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Legrand-Abravanel F, Nicot F, Izopet J. New NS5B polymerase inhibitors for hepatitis C. Exp. Opin. 19(8), 963-975 (2010). Review of NS5B nucleos(t)ide and non-nucleoside inhibitors published in 2010 and before. Includes a comparison of the differences between the two classes.
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β-D-2′-deoxy-2′-fluoro-2′-C-methyluridine phosphoramidates are potent and selective inhibitors of HCV RNA replication
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Presented at
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Furman PA, Bao D, Chang W et al. β-D-2′-deoxy-2′-fluoro- 2′-C-methyluridine phosphoramidates are potent and selective inhibitors of HCV RNA replication. Presented at: 15th International Symposium on Hepatitis C Virus and Related Viruses. San Antonio, TX, USA, 5-9 October 2008.
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15th International Symposium on Hepatitis C Virus and Related Viruses. San Antonio, TX, USA, 5-9 October 2008
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Furman, P.A.1
Bao, D.2
Chang, W.3
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16
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84872757924
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PSI-7851: A novel liver-targeting nucleotide prodrug for the treatment of hepatitis C
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Presented at
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Furman PA, Wang P, Niu C. PSI-7851: a novel liver-targeting nucleotide prodrug for the treatment of hepatitis C. Presented at: The 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). San Francisco, CA, USA, 31 October-4 November 2008.
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The 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). San Francisco, CA, USA, 31 October-4 November 2008
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Furman, P.A.1
Wang, P.2
Niu, C.3
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17
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84872753262
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PROTON: PSI-7977 & peg/RBV in treatment-naive patients with HCV GT1: sustained virologic response
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Presented at
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Lawitz E, Lalezari JP, Hassanein T et al. PROTON: PSI-7977 & peg/RBV in treatment-naive patients with HCV GT1: sustained virologic response. Presented at: The 62th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). San Francisco, CA, USA, 5-8 November 2011.
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The 62th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). San Francisco, CA, USA, 5-8 November 2011
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Lawitz, E.1
Lalezari, J.P.2
Hassanein, T.3
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18
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84872757189
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Antiviral activity, pharmacokinetics, safety, and tolerability of PSI-7851, a novel nucleotide polymerase inhibitor for HCV, following single and 3 day multiple ascending oral doses in healthy volunteers and patients with chronic HCV infection
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Presented at
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Rodriguez-Torres M, Lawitz E, Flach S et al. Antiviral activity, pharmacokinetics, safety, and tolerability of PSI-7851, a novel nucleotide polymerase inhibitor for HCV, following single and 3 day multiple ascending oral doses in healthy volunteers and patients with chronic HCV infection. Presented at: The 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA, 30 October-3 November 2009.
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The 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA, 30 October-3 November 2009
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Rodriguez-Torres, M.1
Lawitz, E.2
Flach, S.3
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19
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84872747665
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Clinical synergy of an anti-HCV nucleotide analog with SOC: Viral kinetics of PSI-7977 with SOC
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Presented at
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Lawitz E, Lalezari JP, Rodriguez-Torres M et al. Clinical synergy of an anti-HCV nucleotide analog with SOC: viral kinetics of PSI-7977 with SOC. Presented at: The 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA, 30 October-2 November 2010.
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The 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA, 30 October-2 November 2010
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Lawitz, E.1
Lalezari, J.P.2
Rodriguez-Torres, M.3
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20
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84872749042
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Lack of effect of the nucleotide analog polymerase inhibitor PSI-7977 on methadone PK and PD
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Presented at
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Denning JM, Cornpropst MT, Clemons D et al. Lack of effect of the nucleotide analog polymerase inhibitor PSI-7977 on methadone PK and PD. Presented at: The 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). San Francisco, CA, USA, 5-8 November 2011.
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The 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). San Francisco, CA, USA, 5-8 November 2011
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Denning, J.M.1
Cornpropst, M.T.2
Clemons, D.3
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21
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84872749654
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PSI-7977 has no effect on QTcF intervals at therapeutic or supratherapeutic doses
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Presented at
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Cornpropst MT, Denning JM, Clemons D et al. PSI-7977 has no effect on QTcF intervals at therapeutic or supratherapeutic doses. Presented at: The 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). San Francisco, CA, USA, 5-8 November 2011.
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The 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). San Francisco, CA, USA, 5-8 November 2011
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Cornpropst, M.T.1
Denning, J.M.2
Clemons, D.3
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23
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84872752720
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High rapid virologic response (RVR) with PSI-7977 daily dosing plus PEG-IFN/RBV in a 28-day Phase 2a trial
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Presented at
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Lawitz E, Lalezari J, Rodriguez-Torres M, Kowdley KV et al. High rapid virologic response (RVR) with PSI-7977 daily dosing plus PEG-IFN/RBV in a 28-day Phase 2a trial. Presented at: The 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA, 30 October-2 November 2010.
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The 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA, 30 October-2 November 2010
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Lawitz, E.1
Lalezari, J.2
Rodriguez-Torres, M.3
Kowdley, K.V.4
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24
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84872756657
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IL28B SNP geographical distribution and antiviral responses in a 28-day Phase 2a trial of PSI-7977 daily dosing plus PEG-IFN/RBV
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Presented at
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McHutchison JG, Goldstein DB, Shianna K et al. IL28B SNP geographical distribution and antiviral responses in a 28-day Phase 2a trial of PSI-7977 daily dosing plus PEG-IFN/RBV. Presented at: The 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA, 30 October-2 November 2010.
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The 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA, 30 October-2 November 2010
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McHutchison, J.G.1
Goldstein, D.B.2
Shianna, K.3
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25
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84872756239
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PROTON study: PSI-7977 QD with PEG/RBV: 12-week safety, RVR, cEVR, & SVR12 in treatment-naive patients with HCV GT2 or GT3
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Presented at
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Lalezari J, Lawitz E, Rodriguez-Torres M et al. PROTON study: PSI-7977 QD with PEG/RBV: 12-week safety, RVR, cEVR, & SVR12 in treatment-naive patients with HCV GT2 or GT3. Presented at: European Association for the Study of the Liver (EASL). The International Liver Congress 2011. Berlin, Germany, 30 March-2 April 2011.
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European Association for the Study of the Liver (EASL). The International Liver Congress 2011. Berlin, Germany, 30 March-2 April 2011
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Lalezari, J.1
Lawitz, E.2
Rodriguez-Torres, M.3
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26
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84856159009
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Preliminary study of two antiviral agents for hepatitis C genotype 1
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Lok A, Gardiner D, Lawitz E et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N. Engl. J. Med. 366(3), 216-224 (2012).
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Lok, A.1
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27
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84872747403
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PSI-treatment-naive 7977: ELECTRON interferon is not required for sustained virologic response in treatment naive patients with HCV GT2 or GT3
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Presented at
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Gane EJ, Stedman CA, Hyland RH et al. PSI-treatment-naive 7977: ELECTRON interferon is not required for sustained virologic response in treatment naive patients with HCV GT2 or GT3. Presented at: The 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). San Francisco, CA, USA, 5-8 November 2011.
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The 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). San Francisco, CA, USA, 5-8 November 2011
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Gane, E.J.1
Stedman, C.A.2
Hyland, R.H.3
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28
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84872750078
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PSI-7977 + ribavirin in HCV genotype 1 null responders: Results from the ELECTRON trial
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Presented at
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Gane E, Stedman C, Anderson J et al. PSI-7977 + ribavirin in HCV genotype 1 null responders: results from the ELECTRON trial. Presented at: 19th Conference on Retroviruses and Opportunistic Infections (CROI). Seattle, WA, USA, 5-8 March 2012.
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19th Conference on Retroviruses and Opportunistic Infections (CROI). Seattle, WA, USA, 5-8 March 2012
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Gane, E.1
Stedman, C.2
Anderson, J.3
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29
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84872747752
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PSI-7977 with PEG/RBV elicits rapid declines in HCV RNA in patients with HCV GT-4 and GT-6
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Presented at
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Hassanein T, Nelson DR, Lawitz E et al. PSI-7977 with PEG/RBV elicits rapid declines in HCV RNA in patients with HCV GT-4 and GT-6. Presented at: HepDart 2011. Kauai, HI, USA, 4-8 December 2011.
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HepDart 2011. Kauai, HI, USA, 4-8 December 2011
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Hassanein, T.1
Nelson, D.R.2
Lawitz, E.3
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30
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84872755157
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Pharmacokinetics, safety, and tolerability of PSI-352938, a novel nucleotide polymerase inhibitor for HCV, following single ascending oral doses in healthy subjects
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Presented at
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Symonds WT, Denning JM, Albanis E et al. Pharmacokinetics, safety, and tolerability of PSI-352938, a novel nucleotide polymerase inhibitor for HCV, following single ascending oral doses in healthy subjects. Presented at: The 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA, 30 October-2 November 2010.
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The 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Boston, MA, USA, 30 October-2 November 2010
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Symonds, W.T.1
Denning, J.M.2
Albanis, E.3
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31
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84872758812
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PSI-7977 QD plus PEG/RBV in HCV GT1: 98% rapid virologic response, complete early virologic response: The PROTON Study
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Presented at
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Nelson DR, Lalezari J, Lawitz E et al. PSI-7977 QD plus PEG/RBV in HCV GT1: 98% rapid virologic response, complete early virologic response: the PROTON Study. Presented at: European Association for the Study of the Liver (EASL). The International Liver Congress 2011. Berlin, Germany, 30 March-2 April 2011.
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European Association for the Study of the Liver (EASL). The International Liver Congress 2011. Berlin, Germany, 30 March-2 April 2011
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Nelson, D.R.1
Lalezari, J.2
Lawitz, E.3
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32
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84857152249
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Centers for Disease Control and Prevention
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Centers for Disease Control and Prevention: Viral Heaptitis Surveillance - United States, 2009. www.cdc.gov/hepatitis/Statistic/2009Surveillance/index. htm
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Viral Heaptitis Surveillance - United States
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36
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Pharmasset Inc. Press Releases
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Pharmasset Inc. Press Releases. http://investor.pharmasset.com/releases. cfm
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