The human capsaicin model of allodynia and hyperalgesia: Sources of variability and methods for reduction

Journal of Pain and Symptom Management

Volumn 16, Issue 1, 1998, Pages 10-20

  Liu, Maywin ^a,c   Max, Mitchell B ^a   Robinovitz, Elaine ^b   Gracely, Richard H ^a   Bennett, Gary J ^a,d  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Capsaicin; Experimental pain model; Mechanical allodynia; Pinprick hyperalgesia

Indexed keywords

CAPSAICIN;

ALLODYNIA; ARTICLE; BLOOD FLOW; CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION FUNCTION; CROSSOVER PROCEDURE; FOOT; FOREARM; HUMAN; HUMAN EXPERIMENT; HYPERALGESIA; INTRADERMAL DRUG ADMINISTRATION; MODEL; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SKIN TEMPERATURE; TOPICAL DRUG ADMINISTRATION; VOLUNTEER;

ADULT; CAPSAICIN; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERALGESIA; MALE; PAIN MEASUREMENT;

EID: 0032127027     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0885-3924(98)00026-8     Document Type: Article

References (20)

1. Simone D.A., Baumann T.K., LaMotte R.H. Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin. Pain. 38:1989;99-107.
2. LaMotte R.H., Shain C.N., Simone D.A., Tsai E.P. Neurogenic hyperalgesia. psychophysical studies of underlying mechanisms J Neurophysiol. 66:1991;190-211.
3. Koltzenburg M., Lundberg L.E.R., Torebjörk H.E. Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain. 51:1992;207-219.
4. Kilo S., Schmelz M., Koltzenburg M., Handwerker H.O. Different patterns of hyperalgesia induced by experimental inflammation in human skin. Brain. 117:1994;385-396.
5. Torebjörk H.E., Lundberg L.E., LaMotte R.H. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol. 448:1992;765-780.
6. Gracely RH, Lynch SA, Bennett GJ. Evidence for A-beta low-threshold mechanoreceptor-mediated mechano-allodynia and cold hyperalgesia following intradermal injection of capsaicin into the foot dorsum. Pain 1993;(suppl 6), 372.
7. Park K.M., Max M.B., Robinovitz E., Gracely R.H., Bennett G.J. Effects of intravenous ketamine, alfentanil,or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in humans. Pain. 63:1995;163-172.
8. Sethna NF, Liu M, Gracely RH, Bennett GJ, Max MB. Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations vs. either drug alone after intradermal capsaicin in normal subjects. Anesthesia & Analgesia, 1998, in press.
9. Culp W.J., Ochoa J., Cline M., Dotson R. Heat and mechanical hyperalgesia induced by capsaicin, cross modality threshold modulation in human C nociceptors. Brain. 112:1989;1317-1331.
10. Gracely R.H., Barcellos S.A., Saltzman S.J., Byas-Smith M.G., Max M.B., Bennett G.J. A-beta mechanoallodynia and cold hyperalgesia following large doses of intradermal capsaicin. Soc Neurosci Abstr. 19:1993;1073.
11. Ferguson G.A. Statistical analysis in psychology and education. 1966;McGraw-Hill, New York.
12. Nathan P.W. Improvement in cutaneous sensibility associated with relief of pain. J Neurol Neurosurg Psychiatry. 23:1960;202-206.
13. Hodge C.J. Jr., King R.B. Medical modification of sensation. J Neurosurg. 44:1976;21-28.
14. Marchettini P., Lacerenza M., Marangoni C., Pellegata G., Sotgiu M.I., Smirne S. Lidocaine test in neuralgia. Pain. 48:1992;377-382.
15. Liu M., Max M.B., Parada S., Rowan J.S., Bennett G.J. Capsaicin-evoked mechanical allodynia but not pinprick hyperalgesia is mediated by the sympathetic nervous system in humans. J Neurosci. 16:1996;7331-7335.
16. Livingston W.K. Pain mechanisms. a physiologic interpretation of causalgia and its related states:1947;MacMillan, New York.
17. Korenman E.M.D., Devor M. Ectopic adrenergic sensitivity in damaged peripheral nerve axons in the rat. Exp Neurol. 72:1981;63-81.
18. Kim S.H., Chung J.M. Sympathectomy alleviates mechanical allodynia in an experimental animal model for neuropathy in the rat. Neurosci Lett. 134:1991;131-134.
19. Levine JD, Taiwo YO, Collins SD, Tam JK. Noradrenaline hyperalgesia is mediated through interaction with sympathetic postganglionic neurone terminals rather than activation of primary nociceptors. Nature 1986,323:158-160.
20. Treede R.D., Davis K.D., Campbell J.N. Raja SN. The plasticity of cutaneous hyperalgesia during sympathetic ganglion blockade in patients with neuropathic pain. Brain. 115:1992;607-621.