Corticosteroid treatment selectively decreases mast cells in the smooth muscle and epithelium of asthmatic bronchi

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 67, Issue 7, 2012, Pages 958-961

  James, Anna ^a   Gyllfors, P ^b   Henriksson, E ^c   Dahlen S E ^a   Adner, M ^a   Nilsson, G ^a   Dahlen B ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ST GÖRAN S HOSPITAL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Asthma; Corticosteroids; Epithelium; Mast cell; Smooth muscle

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; NITRIC OXIDE;

ARTICLE; ASTHMA; BRONCHUS MUCOSA; BRONCHUS MUSCLE; CELL COUNT; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAST CELL; PRIORITY JOURNAL; SUBMUCOSA;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ANTI-ASTHMATIC AGENTS; ASTHMA; BRONCHI; CASE-CONTROL STUDIES; HUMANS; MAST CELLS; MUSCLE, SMOOTH; RESPIRATORY MUCOSA;

EID: 84862001138     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2012.02836.x     Document Type: Article

References (17)

1. Bradding P, Walls AF, Holgate ST. The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol 2006;117:1277-1284. (Pubitemid 43795741)
2. Carroll NG, Mutavdzic S, James AL. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 2002;19:879-885. (Pubitemid 34567902)
3. Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID. Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med 2002;346:1699-1705. (Pubitemid 34547483)
4. Balzar S, Fajt ML, Comhair SA, Erzurum SC, Bleecker E, Busse WW et al. Mast cell phenotype, location, and activation in severe asthma: data from the severe asthma research program. Am J Respir Crit Care Med 2011;183:299-309.
5. Laitinen LA, Laitinen A, Haahtela T. Airway mucosal inflammation even in patients with newly diagnosed asthma. Am Rev Respir Dis 1993;147:697-704. (Pubitemid 23072664)
6. Gyllfors P, Kumlin M, Dahlen SE, Gaber F, Ehrs PO, Dahlen B. Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis. Thorax 2005;60:902-908. (Pubitemid 41598205)
7. Kraft M, Martin RJ, Lazarus SC, Fahy JV, Boushey HA, Lemanske RF Jr et al. Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids. Chest 2003;124:42-50. (Pubitemid 36851329)
8. John M, Oltmanns U, Binder C, Meiners S, Gellert K, Chung KF et al. Inhibition of chemokine production from human airway smooth muscle cells by fluticasone, budesonide and beclomethasone. Pulm Pharmacol Ther 2004;17:41-47. (Pubitemid 37468408)
9. Kim YK, Nakagawa N, Nakano K, Sulakvelidze I, Dolovich J, Denburg J. Stem cell factor in nasal polyposis and allergic rhinitis: increased expression by structural cells is suppressed by in vivo topical corticosteroids. J Allergy Clin Immunol 1997;100:389-399. (Pubitemid 27402783)
10. Bradley BL, Azzawi M, Jacobson M, Assoufi B, Collins JV, Irani AM et al. Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol 1991;88:661-674.
11. Djukanovic R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR et al. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 1992;145:669-674.
12. Bentley AM, Hamid Q, Robinson DS, Schotman E, Meng Q, Assoufi B et al. Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am J Respir Crit Care Med 1996;153:551-556.
13. Wallin A, Sue-Chu M, Bjermer L, Ward J, Sandström T, Lindberg A et al. Effect of inhaled fluticasone with and without salmeterol on airway inflammation in asthma. J Allergy Clin Immunol 2003;112:72-78. (Pubitemid 36819810)
14. Overbeek SE, Mulder PG, Baelemans SM, Hoogsteden HC, Prins J-B. Formoterol added to low-dose budesonide has no additional anti-inflammatory effect in asthmatic patients. Chest 2009;128:1121-1127. (Pubitemid 41324385)
15. Yip KH, Huang Y, Waye MM, Lau HY. Induction of nitric oxide synthases in primary human cultured mast cells by IgE and proinflammatory cytokines. Int Immunopharmacol 2008;8:764-768.
16. Andersson CK, Mori M, Bjermer L, Lofdahl CG, Erjefalt JS. Novel site-specific mast cell subpopulations in the human lung. Thorax 2009;64:297-305.
17. Dougherty R, Sidhu S, Raman K, Solon M, Solberg O, Caughey G et al. Accumulation of intraepithelial mast cells with a unique protease phenotype in TH2-high asthma. J Allergy Clin Immunol 2010;125:1046-1053.