Label-free imaging of basement membranes differentiates normal, precancerous, and cancerous colonic tissues by second-harmonic generation microscopy

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Zhuo, Shuangmu ^a   Yan, Jun ^b   Chen, Gang ^b   Shi, Hong ^b   Zhu, Xiaoqin ^a   Lu, Jianping ^b   Chen, Jianxin ^a   Xie, Shusen ^a  

^a FUJIAN NORMAL UNIVERSITY   (China)

^b FUJIAN PROVINCIAL TUMOR HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BASEMENT MEMBRANE; CANCER STAGING; CANCER TISSUE; CELL DIFFERENTIATION; COLON; COLON ADENOCARCINOMA; COLON ADENOMA; COLON CANCER; CONTROLLED STUDY; DYNAMICS; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MICROSCOPY; OUTCOME ASSESSMENT; POPULATION DENSITY; PRECANCER; QUANTITATIVE ANALYSIS; SECOND HARMONIC GENERATION MICROSCOPY; CLINICAL TRIAL; COLONIC NEOPLASMS; DEVICES; FEMALE; MALE; PATHOLOGY; PRECANCEROUS CONDITIONS; PROCEDURES;

BASEMENT MEMBRANE; COLONIC NEOPLASMS; FEMALE; HUMANS; MALE; MICROSCOPY; PRECANCEROUS CONDITIONS;

EID: 84862001118     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038655     Document Type: Article

References (20)

1. Jemal A, Siegel R, Xu J, Ward E, (2010) Cancer statistics, 2010. CA Cancer J Clin 60: 277 300.
2. Goetz M, Kiesslich R, (2010) Advances of endomicroscopy for gastrointestinal physiology and diseases. Am J Physiol Gastrointest Liver Physiol 298: G797 G806.
3. Jass JR, Whitehall VL, Young J, Leggett BA, (2002) Emerging concepts in colorectal neoplasia. Gastroenterology 123: 862 876.
4. Srivastava S, Henson DE, Gazdar A, (1998) Molecular pathology of early cancer. Amsterdam: IOS Press.
5. Hida J, Matsuda T, Kitaoka M, Machidera N, Kubo R, (1994) The role of basement membrane in colorectal cancer invasion and liver metastasis. Cancer 74: 592 598.
6. Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz CM, (1980) Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 284: 67 68.
7. Visser R, Arends JW, Leigh IM, Bosma FT, (1993) Patterns and composition of basement membranes in colon adenomas and adenocarcinomas. J Pathol 170: 285 290.
8. Zipfel WR, Williams RM, Christie R, Nikitin AY, Hyman BT, (2003) Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation. Proc Natl Acad Sci USA 100: 7075 7080.
9. Campagnola PJ, Loew LM, (2003) Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms. Nat Biotechnol 21: 1356 1360.
10. Zhuo SM, Zheng LQ, Chen JX, Xie SS, Zhu XQ, (2010) Depth-cumulated epithelial redox ratio and stromal collagen quantity as quantitative intrinsic indicators for differentiating normal, inflammatory, and dysplastic epithelial tissues. Appl Phys Lett 97: 173701.
11. Hovhannisyan VA, Su PJ, Dong CY, (2009) Qunatifying thermodynamics of collagen thermal denaturation by second harmonic generation imaging. Appl Phys Lett 94: 233902.
12. Matteini P, Ratto F, Rossi F, Cicchi R, Stringari C, (2009) Photothermally-induced disordered patterns of corneal collagen revealed by SHG imaging. Opt Express 17: 4868 4878.
13. Zhuo SM, Chen JX, Luo TS, Zou DS, Zhao JJ, (2006) Multimode nonlinear optical imaging of the dermis in ex vivo human skin based on the combination of multichannel mode and Lambda mode. Opt Express 14: 7810 7820.
14. Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, (2003) Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat Med 9: 796 800.
15. Campagnolal PJ, Dong CY, (2011) Second harmonic generation microscopy: principles and applications to disease diagnosis. Laser Photonics Rev 5: 13 26.
16. Bosman FT, (1994) The borderline: Basement membranes and the transition from premalignant to malignant neoplasia. Microsc ResTech 28: 216 225.
17. Bao HC, Boussioutas A, Jeremy R, Russell S, Gu M, (2010) Second harmonic generation imaging via nonlinear endomicroscopy. Opt Express 18: 1255 1260.
18. Wu YC, Xi JF, Cobb MJ, Li XD, (2009) Scanning fiber-optic nonlinear endomicroscopy with miniature aspherical compound lens and multimode fiber collector. Opt Lett 34: 953 955.
19. Rivera1 DR, Brown CM, Ouzounov DG, Pavlova I, Kobat D, et al (2011) Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue. Proc Natl Acad Sci USA 108: 17598 17603.
20. Zhuo SM, Chen JX, Wu GZ, Xie SS, Zheng, et al, (2010) Quantitatively linking collagen alteration and epithelial tumor progression by second harmonic generation microscopy. Appl Phys Lett 96: 213704.