Clinicopathologic features and prognostic analysis of MSI-high colon cancer

International Journal of Colorectal Disease

Volumn 27, Issue 3, 2012, Pages 277-286

  Lin, Chun Chi ^a,b   Lai, Yi Ling ^a   Lin, Tzu Chen ^a   Chen, Wei Shone ^a,b   Jiang, Jeng Kai ^a,b   Yang, Shung Haur ^a,b   Wang, Huann Sheng ^a,b   Lan, Yuan Tzu ^a,b   Liang, Wen Yih ^a   Hsu, Hui Mei ^a   Lin, Jen Kou ^a,b   Chang, Shih Ching ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Colon cancer; Microsatellite; Mismatch repair; MSI; Prognosis; Replication error

Indexed keywords

CAPECITABINE; FLUOROURACIL; FOLINIC ACID; UFT; ADENOSINE TRIPHOSPHATASE; DNA BINDING PROTEIN; G T MISMATCH BINDING PROTEIN; G-T MISMATCH-BINDING PROTEIN; MLH1 PROTEIN, HUMAN; MSH2 PROTEIN, HUMAN; NUCLEAR PROTEIN; PMS2 PROTEIN, HUMAN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN MSH2; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AGED; ARTICLE; CANCER INCIDENCE; CLINICAL FEATURE; COLON CANCER; COLON RESECTION; CONTROLLED STUDY; FEMALE; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; TAIWAN; TUMOR LOCALIZATION; ADENOCARCINOMA; CANCER STAGING; COLON; COLON TUMOR; DISEASE FREE SURVIVAL; GENETICS; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; MISMATCH REPAIR; MULTIVARIATE ANALYSIS; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; SEX DIFFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOCARCINOMA; ADENOSINE TRIPHOSPHATASES; AGED; AGED, 80 AND OVER; COLON; COLONIC NEOPLASMS; DISEASE-FREE SURVIVAL; DNA MISMATCH REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; FEMALE; GENOTYPE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MULTIVARIATE ANALYSIS; MUTS HOMOLOG 2 PROTEIN; NEOPLASM STAGING; NUCLEAR PROTEINS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; SEX FACTORS;

EID: 84861986852     PISSN: 01791958     EISSN: 14321262     Source Type: Journal    
DOI: 10.1007/s00384-011-1341-2     Document Type: Article

References (44)

1. Dept. of Health, the executive yuan, R.O.C, 2009 "Cancer registry annual report, Taiwan, R.O.C. (2006)."
2. Soreide K, Janssen EA, Soiland H et al (2006) Microsatellite instability in colorectal cancer. Br J Surg 93:395-406
3. Aaltonen LA, Peltomaki P, Leach FS et al (1993) Clues to the pathogenesis of familial colorectal cancer. Science 260:812-816
4. Thibodeau SN, French AJ, Cunningham JM et al (1998) Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer Res 58:1713-1718
5. Eshleman JR, Markowitz SD (1996) Mismatch repair defects in human carcinogenesis. Hum Mol Genet Spec No:1489-1494
6. Boland CR, Thibodeau SN, Hamilton SR et al (1998) A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58:5248-5257
7. Gafa R, Maestri I, Matteuzzi M et al (2000) Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability. Cancer 89:2025-2037
8. Ionov Y, Peinado MA, Malkhosyan S et al (1993) Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363:558-561
9. Jass JR, Do KA, Simms LA et al (1998) Morphology of sporadic colorectal cancer with DNA replication errors. Gut 42:673-679
10. Thibodeau SN, Bren G, Schaid D (1993) Microsatellite instability in cancer of the proximal colon. Science 260:816-819
11. Lothe RA, Peltomaki P, Meling GI et al (1993) Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 53:5849-5852
12. Benatti P, Gafa R, Barana D et al (2005) Microsatellite instability and colorectal cancer prognosis. Clin Cancer Res 11:8332-8340
13. Sinicrope FA, Rego RL, Halling KC et al (2006) Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients. Gastroenterology 131:729-737
14. Gryfe R, Kim H, Hsieh ET et al (2000) Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med 342:69-77
15. Popat S, Hubner R, Houlston RS (2005) Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol 23:609-618
16. Kim GP, Colangelo LH, Wieand HS et al (2007) Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study. J Clin Oncol 25:767-772
17. Curran B, Lenehan K, Mulcahy H et al (2000) Replication error phenotype, clinicopathological variables, and patient outcome in Dukes' B stage II (T3, N0, M0) colorectal cancer. Gut 46:200-204
18. Ikeda Y, Oda S, Abe T et al (2001) Features of microsatellite instability in colorectal cancer: comparison between colon and rectum. Oncology 61:168-174
19. Kim H, Jen J, Vogelstein B, Hamilton SR (1994) Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 145:148-156
20. Ishikubo T, Nishimura Y, Yamaguchi K et al (2004) The clinical features of rectal cancers with high-frequency microsatellite instability (MSI-H) in Japanese males. Cancer Lett 216:55-62
21. Vasen HF, Watson P, Mecklin JP, Lynch HT (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the international collaborative group on HNPCC. Gastroenterology 116:1453-1456
22. Edge SB, Byrd DR, Compton CC et al (2010) AJCC cancer staging manual, 7th edn. Springer, New York
23. Lin JK, Chang SC, Yang YC, Li AF (2003) Loss of heterozy-gosity and DNA aneuploidy in colorectal adenocarcinoma. Ann Surg Oncol 10:1086-1094
24. Chang S-C, Lin J-K, Yang SH et al (2006) Relationship between genetic alterations and prognosis in sporadic colorectal cancer. Int J Cancer 118:1721-1727
25. Chang SC, Lin PC, Yang SH et al (2010) Taiwan hospital-based detection of Lynch syndrome distinguishes 2 types of microsatellite instabilities in colorectal cancers. Surgery 147(5):720-728
26. Nehls O, Hass HG, Okech T et al (2009) Prognostic implications of BAX protein expression and microsatellite instability in all non-metastatic stages of primary colon cancer treated by surgery alone. Int J Colorectal Dis 24:655-663
27. Elsaleh H, Powell B, Soontrapornchai P et al (2000) p53 gene mutation, microsatellite instability and adjuvant chemotherapy: impact on survival of 388 patients with Dukes' C colon carcinoma. Oncology 58:52-59
28. Ribic CM, Sargent DJ, Moore MJ et al (2003) Tumor microsatellite- instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 349:247-257
29. Kochhar R, Halling KC, McDonnell S et al (1997) Allelic imbalance and microsatellite instability in resected Duke's D colorectal cancer. Diagn Mol Pathol 6:78-84
30. Buckowitz A, Knaebel HP, Benner A et al (2005) Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases. Br J Cancer 92:1746-1753
31. Kim ST, Lee J, Park SH et al (2010) Clinical impact of microsatellite instability in colon cancer following adjuvant FOLFOX therapy. Cancer Chemother Pharmacol 66(4):659-667
32. Westra JL, Schaapveld M, Hollema H et al (2005) Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. J Clin Oncol 23:5635-5643
33. Sinicrope FA, Rego RL, Foster N et al (2006) Microsatellite instability accounts for tumor site-related differences in clinico-pathologic variables and prognosis in human colon cancers. Am J Gastroenterol 101:2818-2825
34. Guidoboni M, Gafa R, Viel A et al (2001) Microsatellite instability and high content of activated cytotoxic lymphocytes identify colon cancer patients with a favorable prognosis. Am J Pathol 159:297-304
35. Samowitz WS, Curtin K, Ma KN et al (2001) Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level. Cancer Epid Bio Prev 10:917-923
36. Deschoolmeester V, Van Damme N, Baay M et al (2008) Microsatellite instability in sporadic colon carcinomas has no independent prognostic value in a Belgian study population. Eur J Cancer 44:2288-2295
37. Watanabe T, Wu TT, Catalano PJ et al (2001) Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med 344:1196-1206
38. Barratt PL, Seymour MT, Stenning SP et al (2002) DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study. Lancet 360:1381-1391
39. Samowitz WS, Holden JA, Curtin K et al (2001) Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer. Am J Pathol 158:1517-1524
40. Anwar S, Frayling IM, Scott NA, Carlson GL (2004) Systematic review of genetic influences on the prognosis of colorectal cancer. Br J Surg 91:1275-1291
41. Yoon YS, Yu CS, Kim TW et al (2011) Mismatch repair status in sporadic colorectal cancer: immunohistochemistry and microsatellite instability analyses. J Gastroenterol Hepatol. [Epub ahead of print]
42. Lanza G, Gafa R, Santini A et al (2006) Immunohistochemical test for MLH1 and MSH2 expression predicts clinical outcome in stage II and III colorectal cancer patients. J Clin Oncol 24:2359-2367
43. Marcus VA, Madlensky L, Gryfe R et al (1999) Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors. Am J Surg Pathol 23:1248-1255
44. Shia J, Ellis NA, Klimstra DS (2004) The utility of immunohis-tochemical detection of DNA mismatch repair gene proteins. Virchows Arch 445:431-441