Social anxiety modulates risk sensitivity through activity in the anterior insula

Frontiers in Neuroscience

Volumn , Issue JAN, 2012, Pages

  Tang, Grace S ^a   van den Bos, Wouter ^a   Andrade, Eduardo B ^b   McClure, Samuel M ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anterior cingulate cortex; Anterior insula; Intraparietal sulcus; Risk; Social anxiety; SPIN

Indexed keywords

ADULT; ANTERIOR CINGULATE; ANTERIOR INSULA; ARTICLE; BEHAVIOR; DECISION MAKING; ELECTROENCEPHALOGRAM; HIGH RISK BEHAVIOR; HUMAN; HUMAN EXPERIMENT; INTRAPARIETAL SULCUS; MALE; NEUROIMAGING; NORMAL HUMAN; SCORING SYSTEM; SOCIAL BEHAVIOR; SOCIAL PHOBIA; SOCIAL PHOBIA INVENTORY;

EID: 84861933781     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2011.00142     Document Type: Article

References (45)

1. Baumgartner, T., Heinrichs, M., Vonlan-then, A., Fischbacher, U., and Fehr, E. (2008). Oxytocin shapes the neural circuitry of trust and trust adapta-tionin humans. Neuron 58,639-650.
2. Bossaerts, P. (2010). Risk and risk prediction error signals in anterior insula. Brain Struct. Funct. 214, 645-653.
3. Brand, M., Grabenhorst, F., Starcke, K., Vandekerckhove, M. M. P., and Markowitsch, H. J. (2007). Role of the amygdala in decisions under ambiguity and decisions under risk: evidence from patients with Urbach-Wiethe disease. Neuropsychologia 45, 1305-1317.
4. Bröder, A., and Hohmann, N. (2003). Variations in risk taking behavior over the menstrual cycle. Evol. Hum. Behav. 24, 391-398.
5. Casey, B. J., Somerville, L. H., Gotlib, I. H., Ayduk, O., Franklin, N. T., Askren, M. K., Jonides, J., Berman, M. G., Wilson, N. L., Teslovich, T., Glover, G., Zayas, V., Mischel, W., and Shoda, Y. (2011). Behavioral and neural correlates of delay of gratification 40 years later. Proc. Natl. Acad. Sci. U.S.A. 108, 14998-15003.
6. Charness, G., and Rabin, M. (2002). Understanding social preferences with simple tests. Q. J. Econ. 117, 817-869.
7. Charness, G., and Rabin, M. (2005). Expressed preferences and behavior in experimental games. Games Econ. Behav. 53, 151-169.
8. Chavanne, T. J., and Gallup, G. G. (1998). Variation in risk taking behavior among female college students as a function of the menstrual cycle. Evol. Hum. Behav. 19, 27-32.
9. Cohen, M. X., Heller, A. S., and Ran-ganath, C. (2005). Functional connectivity with anterior cingulate and orbitofrontal cortices during decision-making. Cogn. Brain Res. 23, 61-70.
10. Connor, K. M., Davidson, J. R. T., Churchill, L. E., Sherwood, A., Foa, E., and Weisler, R. H. (2000). Psychometric properties of the Social Phobia Inventory (SPIN): new self-rating scale. Br. J. Psychiatry 176, 379-386.
11. Dayan, P., and Huys, Q. J. M. (2008). Serotonin, inhibition, and negative mood. PLoS Comput. Biol. 4, e4. doi:10.1371/journal.pcbi.0040004
12. Deen, B., Pitskel, N. B., and Pelphrey, K. A. (2011). Three systems of insular functional connectivity identified with cluster analysis. Cereb. Cortex 21, 1498-1506.
13. Ekman, P., and Friesen, W. V. (1976). Pictures of Facial Affect. Palo Alto, CA: Consulting Psychologists.
14. Erwin, B., Heimberg, R., Schneier, F., and Liebowitz, M. (2003). Anger experience and expression in social anxiety disorder: pretreatment profile and predictors of attrition and response to cognitive-behavioral treatment. Behav. Ther. 34, 331-350.
15. Etkin, A., and Wager, T. D. (2007). Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am. J. Psychiatry 164, 1476-1488.
16. Glover, G. H., and Lai, S. (1998). Self-navigated spiral fMRI: interleaved versus single-shot. Magn. Reson. Med. 39, 361-368.
17. Glover, G. H., and Law, C. S. (2001). Spiral-in/out BOLD fMRI for increased SNR and reduced susceptibility artifacts. Magn. Reson. Med. 46, 515-522.
18. Hare, T. A., Camerer, C. F., and Rangel, A. (2009). Self-control in decision-making involves modulation of the vmPFC valuation system. Science 324, 646-648.
19. Hsu, M., Bhatt, M., Adolphs, R., Tranel, D., and Camerer, C. F. (2005). Neural systems responding to degrees of uncertainty in human decision-making. Science 310, 1680-1683.
20. Huettel, S. A., Song, A. W., and McCarthy, G. (2005). Decisions under uncertainty: probabilistic context influences activation of prefrontal and parietal cortices. Laterality 25, 3304-3311.
21. Huettel, S. A., Stowe, C. J., Gordon, E. M., Warner, B. T., and Platt, M. L. (2006). Neural signatures of economic preferences for risk and ambiguity. Neuron 49, 765-775.
22. Kashdan, T. B., Collins, R. L., and Elhai, J. D. (2006). Social anxiety and positive outcome expectancies on risk-taking behaviors. Cognit. Ther. Res. 30, 749-761.
23. Kashdan, T. B., and McKnight, P. E. (2010). The darker side of social anxiety: when aggressive impulsiv-ity prevails over shy inhibition. Curr. Dir. Psychol. Sci. 19, 47-50.
24. Kessler, R. C., McGonagle, K. A., Zhao, S., Nelson, C. B., Hughes, M., Esh-leman, S., Wittchen, H. U., and Kendler, K. S. (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch. Gen. Psychiatry 51, 8-19.
25. King-Casas, B., Sharp, C., Lomax-Bream, L., Lohrenz, T., Fonagy, P., and Montague, P. R. (2008). The rupture and repair of cooperation in borderline personality disorder. Science 321, 806-810.
26. Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., and Fehr, E. (2005). Oxytocin increases trust in humans. Nature 435, 673-676.
27. Krueger, F., McCabe, K., Moll, J., Kriegeskorte, N., Zahn, R., Stren-ziok, M., Heinecke, A., and Graf-man, J. (2007). Neural correlates of trust. Proc. Natl. Acad. Sci. U.S.A. 104, 20084-20089.
28. Kuhnen, C. M., and Knutson, B. (2005). The neural basis of financial risk taking. Neuron 47, 763-770.
29. Kurth, F., Zilles, K., Fox, P. T., Laird, A. R., and Eickhoff, S. B. (2010). A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis. Brain Struct. Funct. 214, 519-534.
30. Lerner, J. S., and Keltner, D. (2001). Fear, anger, and risk. J. Pers. Soc. Psychol. 81, 146-159.
31. Maia, T.V., and Frank, M. J.(2011).From reinforcement learning models to psychiatric and neurological disorders. Nat. Neurosci.14, 154-162.
32. Maner, J. K., Richey, J. A., Cromer, K., Mallott, M., Lejuez, C. W., Joiner, T. E., and Schmidt, N. B. (2007). Dis-positional anxiety and risk-avoidant decision-making. Pers. Individ. Dif. 42, 665-675.
33. Mohr, P. N. C., Biele, G., and Heekeren, H. R. (2010). Neural processing of risk. J. Neurosci. 30, 6613-6619.
34. Park, S. Q., Kahnt, T., Beck, A., Cohen, M. X., Dolan, R. J., Wrase, J., and Heinz, A. (2010). Prefrontal cortex fails to learn from reward prediction errors in alcohol dependence. J. Neurosci. 30, 7749-7753.
35. Paulus, M. P., Rogalsky, C., Simmons, A., Feinstein, J. S., and Stein, M. B. (2003). Increased activation in the right insula during risk-taking decision makingisrelatedtoharmavoid-ance and neuroticism. Neuroimage 19, 1439-1448.
36. Preston, A. R., Thomason, M. E., Ochsner, K. N., Cooper, J. C., and Glover, G. H. (2004). Comparison of spiral-in/out and spiral-out BOLD fMRI at 1.5 and 3 T. NeuroImage 21, 291-301.
37. Rangel, A., Camerer, C., and Montague, P. R. (2008). A framework for studying the neurobiology of value-based decision making. Nat. Rev. Neurosci. 9, 545-556.
38. Rushworth, M. F. S., Walton, M. E., Kennerley, S. W., and Bannerman, D. M. (2004). Action sets and decisions in the medial frontal cortex. Trends Cogn. Sci. (Regul. Ed.) 8, 410-417.
39. Sanfey, A. G., Rilling, J. K., Aron-son, J. A., Nystrom, L. E., and Cohen, J. D. (2003). The neural basis of economic decision-making in the Ultimatum Game. Science 300, 1755-1758.
40. Spielberger, C. D. (1983). State-Trait Anxiety Inventory for Adults. Palo Alto, CA: Mind Garden.
41. van den Bos, W., Cohen, M. X., Kahnt, T., and Crone, E. A. (2011). Striatum-medial prefrontal cortex connectivity predicts developmental changes in reinforcement learning. Cereb. Cortex. doi: 10.1093/cer-cor/bhr198
42. van den Bos, W., van Dijk, E., West-enberg, M., Rombouts, S. A. R. B., and Crone, E. A. (2009). What motivates repayment? Neural correlates of reciprocity in the Trust Game. Soc. Cogn. Affect. Neurosci. 4, 294-304.
43. Voelker, R. (1998). France and United Kingdom channel efforts to improve health services. JAMA 280, 681-683.
44. Ward, B. D. (2000). Simultaneous Inference for fMRI Data. Available at: http://afni.nimh.nih.gov/afni/ docpdf/AlphaSim.pdf
45. Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., and Jenike, M. A. (1998). Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J. Neurosci. 18, 411-418.