Design, synthesis, and docking studies of novel ofloxacin analogues as antimicrobial agents

Medicinal Chemistry Research

Volumn 21, Issue 7, 2012, Pages 1403-1410

  Jubie, S ^a   Prabitha, P ^a   Rajesh Kumar, R ^a   Kalirajan, R ^a   Gayathri, R ^a   Sankar, S ^a   Elango, K ^a  

^a JSS COLLEGE OF PHARMACY   (India)

Author keywords

Antimicrobial; Molecular docking; Ofloxacin; Schiff bases

Indexed keywords

9 FLUORO 2,3 DIHYDRO 6 [4,5 DIHYDRO 4 (3 OXO 3 PHENYLPROPYL) 5 SULFANYLENE 1,3,4 OXADIAZOL 2 YL] 3 METHYL L,10 (4 METHYLPIPERAZIN 1 YL) [1,4]OXAZINE[2,3,4 IJ]QUINOLIN 7 ONE; 9 FLUORO 3,7 DIHYDRO 3 METHYL 6 (2 CHLORO N' METHYLENEBENZOHYDRAZIDE) 10 (4 METHYLPIPERAZIN 1 YL) 2H [1,4]OXAZINO[2,3,4 IJ]QUINOLIN 7 ONE; 9 FLUORO 3,7 DIHYDRO 3 METHYL 6 (4 METHOXY N METHYLENEBENZOHYDRAZIDE)10 (4 METHYLPIPERAZIN 1 YL) 2H [1,4]OXAZINO[2,3,4 IJ]QUINOLIN 7 ONE; 9 FLUORO 3,7 DIHYDRO 3 METHYL 6 (N' METHYLENE 3 NITROBENZOHYDRAZIDE) 10 (4 METHYL PIPERAZIN 1 YL) 2H [1,4]OXAZINO[2,3,4 IJ]QUINOLIN 7 ONE; 9 FLUORO 3,7 DIHYDRO 3 METHYL 6 (N' METHYLENEBENZOHYDRAZIDE) 10 (4 METHYL PIPERAZIN 1 YL) 2H [1,4]OXAZINO[2,3,4 IJ]QUINOLIN 7 ONE; 9 FLUORO 3,7 DIHYDRO 3 METHYL L 6 (2 HYDROXY N' METHYLENEBENZOHYDRAZIDE) 10 (4 METHYLPIPERAZIN 1 YL) 2H [1,4]OXAZINO[2,3,4 IJ]QUINOLIN 7 ONE; 9 FLUORO 3,7 DIHYDRO 3 METHYL L 6 (N' METHYLENE HYDROXY 2 CARBOHYDRAZIDE) 10 (4 METHYLPIPERAZIN 1 YL) 2H [1,4]OXAZINO[2,3,4 IJ]QUINOLIN 7 ONE; CARBOXYLIC ACID; DNA TOPOISOMERASE (ATP HYDROLYSING); OFLOXACIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE ACTIVITY RELATION;

EID: 84861915434     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9655-8     Document Type: Article

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