Effects of amitriptyline, fluoxetine, tranylcypromine and venlafaxine on rat vascular smooth muscle in vitro the role of the endothelium

Journal of Physiology and Pharmacology

Volumn 63, Issue 2, 2012, Pages 119-125

  Ribback, S ^a   Pavlovic, D ^a   Herbst, D ^a   Nedeljkov Jancic, R ^b   Wendt, M ^a   Nedeljkov, V ^b   Bleich, S ^c   Frieling, H ^c  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Antidepressants; Endothelium; Nitric oxide; Potassium channels; Relaxation; Smooth muscle contraction

Indexed keywords

AMITRIPTYLINE; CYCLIC GMP; FLUOXETINE; NITRIC OXIDE; PHENYLEPHRINE; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; PROSTAGLANDIN F2 ALPHA; TRANYLCYPROMINE; VENLAFAXINE;

ADRENERGIC TRANSMISSION; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL TONE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; EXCITATION CONTRACTION COUPLING; HYPOTENSION; IN VITRO STUDY; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASODILATATION;

AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS; AORTA, ABDOMINAL; AORTA, THORACIC; CYCLIC AMP; CYCLIC GMP; CYCLOHEXANOLS; DINOPROST; ENDOTHELIUM, VASCULAR; FLUOXETINE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NITRIC OXIDE; PHENYLEPHRINE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHLORIDE; RATS; RATS, INBRED LEW; SEROTONIN UPTAKE INHIBITORS; TRANYLCYPROMINE;

EID: 84861913810     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Pacher P, Ungvari Z, Kecskemeti V, Furst S. Review of cardiovascular effects of fluoxetine, a selective serotonin reuptake inhibitor, compared to tricyclic antidepressants. Curr Med Chem 1998; 5: 381-390.
2. Edwards RP, Miller RD, Roizen MF, et al. Cardiac responses to imipramine and pancuronium during anesthesia with halothane or enflurane. Anesthesiology 1979; 50: 421-425.
3. Glisson SN, Fajardo L, El-Etr AA. Amitriptyline therapy increases electrocardiographic changes during reversal of neuromuscular blockade. Anesth Analg 1978; 57: 77-83.
4. Sprung J, Schoenwald PK, Levy P, Krajewski LP. Treating intraoperative hypotension in a patient on long-term tricyclic antidepressants: a case of aborted aortic surgery. Anesthesiology 1997; 86: 990-992.
5. Huang Y. Inhibition of contractions by tricyclic antidepressants and xylamine in rat vas deferens. Eur J Pharmacol 1997; 327: 41-47.
6. Huang Y, Lau CW. Inhibitory effect of amitriptyline on contraction of the rat isolated trachea. Pharmacology 1997; 54: 312-318.
7. Velasco A, Arruza A, Maroto M, Carvajal A, Fernandez del Busto E, Garcia del Pozo J. Effect of venlafaxine hydrochloride in different preparations of isolated guinea-pig and rat organ tissues. J Auton Pharmacol 1999; 19: 109-113.
8. Feighner J P. Cardiovascular safety in depressed patients: focus on venlafaxine. J Clin Psychiatry 1995; 56: 574-579.
9. Ocharan ME, Asbun J, Valencia I, Castillo C, Castillo EF. A study of the interactions of tricyclic antidepressants with alpha 1-adrenoceptor subtypes in rat aorta and caudal arteries. Proc West Pharmacol Soc 1998; 41: 141-143.
10. Pacher P, Ungvari Z, Kecskemeti V, Friedmann T, Furst S. Serotonin reuptake inhibitors fluoxetine and citalopram relax intestinal smooth muscle. Can J Physiol Pharmacol 2001; 79: 580-584.
11. 2+ sensitivity. Br J Pharmacol 1999; 127: 740-746.
12. Vila JM, Medina P, Segarra G, et al. Relaxant effects of antidepressants on human isolated mesenteric arteries. Br J Clin Pharmacol 1999; 48: 223-229.
13. Itoh T. Pharmacomechanical coupling in vascular smooth muscle cells-an overview. Jpn J Pharmacol 1991; 55: 1-9.
14. Somlyo AV, Somlyo AP. Electromechanical and pharmacomechanical coupling in vascular smooth muscle. J Pharmacol Exp Ther 1968; 159: 129-145.
15. 2+) channel opener. Stroke 1999; 30: 1949-1954.
16. 2+ influx. Circ Res 1999; 84: 210-219.
17. Czubak A, Nowakowska E, Golembiowska K, Kus K, Burda K, Metelska J. Effect of venlafaxine and nicotine on the level of neurotransmitters and their metabolites in rat brains. J Physiol Pharmacol 2010; 61: 339-346.
18. Abdelmawla AH, Langley RW, Szabadi E, Bradshaw CM. Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline- and methoxamine-evoked constriction of the dorsal hand vein. Br J Clin Pharmacol 1999; 48: 345-354.
19. Reeve HL, Nelson DP, Archer SL, Weir EK. Effects of fluoxetine, phentermine, and venlafaxine on pulmonary arterial pressure and electrophysiology. Am J Physiol 1999; 276: L213-L219.
20. Sozzani S, Agwu DE, McCall CE, et al. Propranolol, a phosphatidate phosphohydrolase inhibitor, also inhibits protein kinase C. J Biol Chem 1992; 267: 20481-20488.
21. Couture L, Elie R, Lavoie PA. Effect of antidepressants on ATP-dependent calcium uptake by neuronal endoplasmic reticulum. Can J Physiol Pharmacol 2001; 79: 946-952.
22. Huang Y. Inhibitory effect of noradrenaline uptake inhibitors on contractions of rat aortic smooth muscle. Br J Pharmacol 1996; 117: 533-539.
23. Nojimoto FD, Mueller A, Hebeler-Barbosa F, et al. The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1β-adrenoceptors. Neuropharmacology 2010; 59: 49-57.
24. Tuncok Y, Kalkan S, Murat N, et al. The effect of the nitric oxide synthesis inhibitor L-NAME on amitriptyline-induced hypotension in rats. J Toxicol Clin Toxicol 2002; 40: 121-127.
25. Rehavi M, Weiss H, Nissenkorn I, Rubinstein R, Cohen S. A comparative study of the affinities of some tricyclic antidepressants for the muscariniccholinergic receptor in human and guinea-pig bladder, ileum and brain in relation to differential drug potency. Life Sci 1987; 40: 1819-1827.
26. Kalkan S, Hocaoglu N, Akgun A, Gidener S, Tuncok Y. Effects of adenosine receptor antagonists on amitriptyline-induced vasodilation in rat isolated aorta. Clin Toxicol (Phila). 2007; 45: 600-604.
27. Frieling H, Bleich S. Tranylcypromine: new perspectives on an "old" drug. Eur Arch Psychiatry Clin Neurosci 2006; 256: 268-273.
28. Bujak-Gizycka B, Olszanecki R, Suski M, Madek J, Stachowicz A, Korbut R. Angiotensinogen metabolism in rat aorta: robust formation of proangiotensin-12. J Physiol Pharmacol 2010; 61: 679-682.
29. Senejoux F, Girard-Thernier C, Berthelot A, Bevalot F, Demougeot C. New insights into the mechanisms of the vasorelaxant effects of apocynin in rat thoracic aorta. Fundam Clin Pharmacol 2012; doi: 10.1111/j.1472-8206.2011.01025.x. (epub ahead of print)
30. Kajita M, Murata T, Horiguchi K, Iizuka M, Hori M, Ozaki H. iNOS expression in vascular resident macrophages contributes to circulatory dysfunction of splanchnic vascular smooth muscle contractions in portal hypertensive rats. Am J Physiol Heart Circ Physiol 2011; 300: H1021-H1031.
31. Skogvall S, Berglund M, Dalence-Guzman MF, et al. Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. Pulm Pharmacol Ther 2007; 20: 273-280.
32. Kudoh A, Katagai H, Takazawa T. Antidepressant treatment for chronic depressed patients should not be discontinued prior to anesthesia. Can J Anaesth 2002; 49: 132-136.