Cancer research, a field on the verge of a paradigm shift?

Trends in Molecular Medicine

Volumn 18, Issue 6, 2012, Pages 299-303

  Goldstein, Ido ^a   Madar, Shalom ^a   Rotter, Varda ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Cancer; Chemotherapy; Kuhn; Paradigm shift; Targeted therapy

Indexed keywords

ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; CHLORMETHINE; IMATINIB;

ANTINEOPLASTIC ACTIVITY; BIOENGINEERING; CANCER CELL; CANCER CHEMOTHERAPY; CANCER IMMUNIZATION; CANCER MORTALITY; CANCER PREVENTION; CANCER RESEARCH; CANCER RISK; CANCER SURGERY; CANCER SUSCEPTIBILITY; CANCER THERAPY; CARCINOGENESIS; CELL DIVISION; CHEMOPROPHYLAXIS; CHRONIC DISEASE; CHRONIC MYELOID LEUKEMIA; CONCEPTUAL FRAMEWORK; DRUG RESEARCH; ENVIRONMENTAL EXPLOITATION; GENE MUTATION; HUMAN; INFLAMMATION; LIFESTYLE MODIFICATION; LUNG CANCER; MEDICAL DEVICE; MOLECULARLY TARGETED THERAPY; NEOPLASM; NOTE; ONCOGENESIS AND MALIGNANT TRANSFORMATION; PERSONALIZED MEDICINE; PHILADELPHIA 1 CHROMOSOME; SMOKING; SOLID TUMOR; TUMOR MICROENVIRONMENT;

HUMANS; NEOPLASMS; RESEARCH;

EID: 84861900896     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2012.04.002     Document Type: Note

References (16)

1. Malakoff D. Can treatment costs be tamed? Science 2011, 331:1545-1547.
2. Siegel R., et al. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J. Clin. 2011, 61:212-236.
3. Strebhardt K., Ullrich A. Paul Ehrlich's magic bullet concept: 100 years of progress. Nat. Rev. Cancer 2008, 8:473-480.
4. Nowell P.C. The clonal evolution of tumor cell populations. Science 1976, 194:23-28.
5. Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990, 61:759-767.
6. Gilman A. The initial clinical trial of nitrogen mustard. Am. J. Surg. 1963, 105:574-578.
7. Chabner B.A., Roberts T.G. Timeline: chemotherapy and the war on cancer. Nat. Rev. Cancer 2005, 5:65-72.
8. Sawyers C.L. Shifting paradigms: the seeds of oncogene addiction. Nat. Med. 2009, 15:1158-1161.
9. Paget S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev. 1989, 8:98-101.
10. Gatenby R.A., Gillies R.J. A microenvironmental model of carcinogenesis. Nat. Rev. Cancer 2008, 8:56-61.
11. Joyce J.A. Therapeutic targeting of the tumor microenvironment. Cancer Cell 2005, 7:513-520.
12. Balkwill F., Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001, 357:539-545.
13. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
14. Gatenby R.A. A change of strategy in the war on cancer. Nature 2009, 459:508-509.
15. Pasquier E., et al. Metronomic chemotherapy: new rationale for new directions. Nat. Rev. Clin. Oncol. 2010, 7:455-465.
16. Bode A.M., Dong Z. Cancer prevention research - then and now. Nat. Rev. Cancer 2009, 9:508-516.