Urine is a highly cytotoxic agent: Does it influence stem cell therapies in urology?

Transplantation Proceedings

Volumn 44, Issue 5, 2012, Pages 1439-1441

  Adamowicz, J ^a   Kloskowski, T ^a   Tworkiewicz, J ^a   Pokrywczynska M ^a   Drewa, T ^a,b  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^b City Hospital Toru   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COUNT; CYTOTOXICITY; HEMATOPOIETIC STEM CELL; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STEM CELL TRANSPLANTATION; URINE; UROLOGY;

ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; MESENCHYMAL STROMAL CELLS; RATS; RATS, WISTAR; TIME FACTORS; URINARY CATHETERIZATION; URINE;

EID: 84861899349     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2012.01.128     Document Type: Article

References (14)

1. Drewa T: Using hair-follicle stem cells for urinary bladder-wall regeneration. Regen Med 3:939, 2008
2. Burst VR, Gillis M, Pütsch F, et al: Poor cell survival limits the beneficial impact of mesenchymal stem cell transplantation on acute kidney injury. Nephron Exp Nephrol 11:4107, 2010
3. Kinebuchi Y, Aizawa N, Imamura T, et al: Autologous bone-marrow-derived mesenchymal stem cell transplantation into injured rat urethral sphincter. Int J Urol 17:359, 2010
4. Oliveira PA, Pires MJ, Nóbrega C, et al: Technique of bladder catheterization in female mice and rats for intravesical instillation in models of bladder cancer. Scand J Lab Anim Sci 36:5, 2009
5. Ferguson MWJ, O'Kane S: Scar free healing: from embryonic mechanisms to adult therapeutic intervention. Phil Trans R Soc Lond B 359:839, 2004
6. Matoka DJ, Cheng EY: Tissue engineering in urology. Can Urol Assoc J 3:403, 2009
7. Drewa T, Adamowicz J, Lysik J, et al: Chitosan scaffold enhances nerve regeneration within the in vitro reconstructed bladder wall: an animal study. Urol Int 81:330, 2008
8. Drewa T, Sir J, Czajkowski R, et al: Scaffold seeded with cells is essential in urothelium regeneration and tissue remodeling in vivo after bladder augmentation using in vitro engineered graft. Transplant Proc 38:133, 2006
9. Drzewiecki BA, Thomas JC, Tanaka ST: Bone marrow-derived mesenchymal stem cells: current and future applications in the urinary bladder. Stem Cells Int 765167, 2011
10. Ortiz LA, Gambelli F, McBride C, et al: Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A 100:8407, 2003
11. Nishijima S, Sugaya K, Miyazato M, et al: Restoration of bladder contraction by bone marrow transplantation in rats with underactive bladder. Biomed Res 28:275, 2007
12. Davis NF, Callanan A, McGuire BB, et al: Evaluation of viability and proliferative activity of human urothelial cells cultured onto xeno-genic tissue-engineered extracellular matrices. Urology 77:1007, 2011
13. Wlodarski K, Kuzaka B, Wlodarski P, et al: Is heterotopic bone formation, occurring near a cut ureter, a sign of osteoinductive potency of human urothelium? Urol Int 55:115, 1995
14. Lu M, Zhou G, Liu W, et al: Remodeling of buccal mucosa by bladder microenvironment. Urology 75:7, 2010