An efficient one-pot cyclization of quinoline thiosemicarbazones to quinolines derivatized with 1,3,4-thiadiazole as anticancer and anti-tubercular agents

Medicinal Chemistry Research

Volumn 21, Issue 2, 2012, Pages 185-191

  Marganakop, Sheetal B ^a   Kamble, Ravindra R ^a   Taj, Tasneem ^a   Kariduraganvar, Mahadevappa Y ^a  

^a KARNATAK UNIVERSITY   (India)

Author keywords

1,3,4 Thiadiazole; Anticancer activity; Antitubercular activity; C log P; Cyclization; Quinoline; SAR

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; ACETIC ANHYDRIDE; ANTINEOPLASTIC AGENT; N [4 ACETYL 5(2 CHLORO 6 METHOXYQUINOLIN 3 YL) 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL] ACETAMIDE; N [4 ACETYL 5(2 CHLORO 6 METHYLQUINOLIN 3 YL) 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL] ACETAMIDE; N [4 ACETYL 5(2 CHLORO 6,7 DIMETHOXYQUINOLIN 3 YL) 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL] ACETAMIDE; N [4 ACETYL 5(2 CHLORO 7 METHOXYQUINOLIN 3 YL) 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL] ACETAMIDE; N [4 ACETYL 5(2 CHLORO 7 METHYLQUINOLIN 3 YL) 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL] ACETAMIDE; N [4 ACETYL 5(2 CHLORO 8 METHOXYQUINOLIN 3 YL) 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL] ACETAMIDE; N [4 ACETYL 5(2 CHLORO 8 METHYLQUINOLIN 3 YL) 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL] ACETAMIDE; N [4 ACETYL 5(2 CHLOROQUINOLIN 3 YL) 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL] ACETAMIDE; N [4 ACETYL 5(2,6 DICHLOROQUINOLIN 3 YL) 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL] ACETAMIDE; N [4 ACETYL 5(6 BROMO 2 CHLOROQUINOLIN 3 YL) 4,5 DIHYDRO 1,3,4 THIADIAZOL 2 YL] ACETAMIDE; QUINOLINE DERIVATIVE; THIOSEMICARBAZONE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYCLIZATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ONE POT SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; UTERINE CERVIX CANCER;

EID: 84861880315     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-010-9522-z     Document Type: Article

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