Pancreatic abnormalities at a young age in Spontaneously Diabetic Torii (SDT) rats

Journal of Animal and Veterinary Advances

Volumn 11, Issue 9, 2012, Pages 1322-1326

  Ohta, Takeshi ^a,b   Shinohara, Masami ^c   Yamamoto, Takuji ^a,b   Yamada, Takahisa ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c CLEA Japan Inc   (Japan)

Author keywords

HOMA; IGT; Insulin content; Pancreatic; Reduction; SDT rat

Indexed keywords

EID: 84861877057     PISSN: 16805593     EISSN: 1993601X     Source Type: Journal    
DOI: 10.3923/javaa.2012.1322.1326     Document Type: Article

References (24)

1. Bloomgarden, Z.T., 2008. Approaches to treatment of pre-diabetes and obesity and promising new approaches to type 2 diabetes. Diabetes Care, 31: 1461-1466.
2. Butler, A.E., J. Janson, S. Bonner-Weir, R. Ritzel, R.A. Rizza and P.C. Butler, 2003. p-cell deficit and increased a-cell apoptosis in human with type 2 diabetes. Diabetes, 52: 102-110.
3. Campbell, I.W. and S. Mariz, 2007. [3-cell preservation with thiazolidinediones. Diabetes Res. Clin. Pract, 76: 163-176.
4. Delghingaro-Augusto, V., C.J. Nolan, D. Gupta, T.L. Jetton and M.G. Latour et al, 2009. Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: Severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass. Diabetologia, 52: 1122-1132.
5. Gillies, C.L., K.R. Abrams, P.C. Lambert, N.J. Cooper, AJ. Sutton, R.T. Hsu and K. Khunti, 2007. Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: Systematic review and meta-analysis. Br. Med. J., 334: 299-307.
6. Haffner, S.M., H. Miettinen and M.P. Stern, 1997. The homeostasis model in the San Antonio heart study. Diabetes Care, 20: 1087-1092.
7. Iida, M., T. Murakami, K. Ishida, A. Mizuno, M. Kuwajima and K. Shima, 1996. Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. Biochem. Biophys. Res. Commun., 222: 19-26.
8. Kenny, A.J., 1955. Extractable glucagon of the human pancreas. J. Clin. Endocrinol. Metab., 15: 1089-1105.
9. Li, J., H. Tian, Q. Li, N. Wang and T. Wu et al, 2007. Improvement of insulin sensitivity and [3-cell function by nateglinide and repaglinide in type 2 diabetic patients: A randomized controlled double-blind and double-dummy multicentre clinical trial. Diabetes Obesity Metab., 9: 558-565.
10. Liu, Y.Q., T.L. Jetton and J.L. Leahy, 2002. (i-cell adaptation to insulin resistance: increased pyruvate carboxylase and malate pyruvate shuttle activity in islets of nondiabetic zucker fatty rats. J. Biol. Chem., 277: 39163-39168.
11. Masuyama, T., K. Komeda, A. Hara, M. Noda and M. Shinohara et al, 2004. Chronological characterization of diabetes development in male Spontaneously Diabetic Toriirats. Biochem. Biophys. Res. Commun., 314: 870-877.
12. Matsui, K., T. Oda, E. Nishizawa, R. Sano and H. Yamamoto, et al, 2009. Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage. Exp. Anim., 58: 363-374.
13. Matsumoto, K., S. Miyake, M. Yano, Y. Ueki, Y. Yamaguchi, S. Akazawa and Y. Tominaga, 1997. Glucose tolerance, insulin secretion and insulin sensitivity in nonobese and obese Japanese subjects. Diabetes Care, 20: 1562-1568.
14. Matthews, D.R., J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher and R.C. Turner, 1985. Homeostasis model assessment: Insulin resistance and [i-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia, 28: 412-419.
15. Meier, J.J., B.A. Menge, T.G.K. Breuer, C.A. Muller, W.U. Tannapfel, W.E. Schmidt and H. Schrader, 2009. Functional assessment of pancreatic [3-cell area in humans. Diabetes, 58: 1595-1603.
16. Ohta, T., K. Matsui, K. Miyajima, T. Sasase, T. Masuyama et al, 2007. Effect of insulin therapy on renal changes in Spontaneously Diabetic Torii rats. Exp. Anim., 56: 355-362.
17. Ohta, T., K. Miyajima and T. Yamada, 2011. Pathophysiological changes in pre-diabetic stage of spontaneously diabetic torii (SDT) rats. J. Anim. Vet. Adv., 10: 813-817.
18. Pickavance, L.C. and J.P.H. Wilding, 2007. Effects of S 15511, a therapeutic metabolite of the insulin-sensitizing agent S 15261, in the Zucker diabetic fatty rat. Diabetes Obesity Metab., 9: 114-120.
19. Rhee, E.J., J.H. Choi, S.H. Yoo, J.C. Bae and W.J. Kim et al., 2011. The association of unintentional changes in weight, body composition and homeostasis model assessment index with glycemic progression in non-diabetic healthy subjects. Diabetes Metab. J., 35: 138-148.
20. Sasase, T., T. Ohta, N. Ogawa, K. Miyajima and M. Ito et al., 2006. Preventive effects of glycaemic control on ocular complications of spontaneously diabetic torii rats. Diabetes Obes. Metab., 8: 501-507.
21. Shinohara, M., T. Masuyama, T. Shoda, T. Takahashi and Y. Katsuda et al, 2000. A new spontaneously diabetic non-obese Torii rat strain with severe ocular complications. Int. J. Exp. Diabetes Res., 1: 89-100.
22. UK Prospective Diabetes Study Group, 1995. UK. prospective diabetes study 16. Overview of 6 years therapy of type 2 diabetes: A progressive disease. Diabetes, 44: 1249-1258.
23. Wallace, T.M., J.C. Levy andD.R. Matthews, 2004. Use and abuse of HOMA modeling. Diabetes Care, 27: 1487-1495.
24. Zhang, W., Y.C. Xu, F.J. Guo, Y. Meng and M.L. Li, 2008. Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-bmding protein 4 expression in rats with type 2 diabetes mellitus. Chin. Med. J., 121: 2124-2128.