The Role of Uric Acid in the Pathogenesis of Hypertension in the Young

Journal of Clinical Hypertension

Volumn 14, Issue 6, 2012, Pages 346-352

  Feig, Daniel I ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; SODIUM; URIC ACID;

ARTERIOLOSCLEROSIS; BLOOD PRESSURE; CARDIOVASCULAR RISK; CELL PROLIFERATION; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE SEVERITY; ESSENTIAL HYPERTENSION; HUMAN; HYPERTENSION; HYPERURICEMIA; NATRIURESIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; URIC ACID BLOOD LEVEL; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; WHITE COAT HYPERTENSION;

AGE FACTORS; ANIMALS; CHILD; CHILD WELFARE; DISEASE MODELS, ANIMAL; HUMANS; HYPERTENSION; HYPERURICEMIA; RISK FACTORS; UNITED STATES; URIC ACID;

EID: 84861849082     PISSN: 15246175     EISSN: 17517176     Source Type: Journal    
DOI: 10.1111/j.1751-7176.2012.00662.x     Document Type: Review

References (76)

1. Mahomed F. The etiology of Bright's disease and the prealbuminuric state. Med Chir Trans. 1874;39:197-228.
2. Mahomed FA. On chronic Bright's disease, and its essential symptoms. Lancet. 1879;1:399-401.
3. Haig A. Uric Acid as a Factor in the Causation of Disease. 4th edn London, UK: J & A Churchill; 1897.
4. Davis NC. The cardiovascular and renal relations and manifestations of gout. JAMA. 1897;29:261-262.
5. Huchard H. Arteriolosclerosis: including its cardiac form. JAMA. 1909;53:1129.
6. Desgrez A. Influence de la constitution des corps puriques sure leur action vis-a vis de la pression arterielle. Comptes Rendus de l'Academie des Sciences. 1913;156:93-94.
7. Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med. 1999;131:7-13.
8. Gutierrez-Macias A, Lizarralde-Palacios E, Martinez-Odriozola P, Miguel-De-La-Villa F. Fatal allopurinol hypersensitivity syndrome after treatment of asymptomatic hyperuricemia. Br Med J (Clin Res Ed). 2005;331:623-624.
9. Kahn HA, Medalie JH, Neufeld HN, et al. The incidence of hypertension and associated factors: the Israel ischemic heart study. Am Heart J. 1972;84:171-182.
10. Dyer AR, Liu K, Walsh M, et al. Ten-year incidence of elevated blood pressure and its predictors: the CARDIA study Coronary Artery Risk Development in (Young) Adults. J Hum Hypertens. 1999;13:13-21.
11. Imazu M, Yamamoto H, Toyofuku M, et al. Hyperinsulinemia for the development of hypertension: data from the Hawaii-Los Angeles-Hiroshima Study. Hypertens Res. 2001;24:531-536.
12. Masuo K, Kawaguchi H, Mikami H, et al. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension. 2003;42:474-480.
13. Nagahama K, Inoue T, Iseki K, et al. Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan. Hypertens Res. 2004;27:835-841.
14. Nakanishi N, Okamato M, Yoshida H, et al. Serum uric acid and the risk for development of hypertension and imparied fasting glucose or type II diabetes in Japanese male office workers. Eur J Epidemiol. 2003;18:523-530.
15. Taniguchi Y, Hayashi T, Tsumura K, et al. Serum uric acid and the risk for hypertension and type 2 diabetes in Japanese men. The Osaka Health Survey. J Hypertens. 2001;19:1209-1215.
16. Torok E, Gyarfas I, Csukas M. Factors associated with stable high blood pressure in adolescents. J Hypertens Suppl. 1985;3(Suppl 3):S389-S390.
17. Rovda Iu I. [Uric acid and arterial hypertension]. Pediatriia. 1992;10-12:74-78.
18. Goldstein HS, Manowitz P. Relation between serum uric acid and blood pressure in adolescents. Ann Hum Biol. 1993;20:423-431.
19. Nefzger MD, Acheson RM, Heyman A. Mortality from stroke among U.S. veterans in Georgia and 5 western states I. Study plan and death rates. J Chronic Dis. 1973;26:393-404.
20. Saito I, Folsom AR, Brancati FL, et al. Nontraditional risk factors for coronary heart disease incidence among persons with diabetes: the Atherosclerosis Risk in Communities (ARIC) Study. Ann Intern Med. 2000;133:81-91.
21. Staessen J. The determinants and prognostic significance of serum uric acid in elderly patients of the European Working Party on High Blood Pressure in the Elderly trial. Am J Med. 1991;90:50S-54S.
22. Alper AB Jr, Chen W, Yau L, et al. Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study. Hypertension. 2005;45:34-38.
23. Sundstrom J, Sullivan L, D'Agostino RB, et al. Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. Hypertension. 2005;45:28-33.
24. Silverstein D, Srivaths PR, Mattison P, et al. Serum uric acid is associated with high blood pressure in pediatric hemodialysis patients. Pediatr Nephrol. 2011;26:1123-1128.
25. Reyes AJ. The increase in serum uric acid concentration caused by diuretics might be beneficial in heart failure. Eur J Heart Fail. 2005;7:461-467.
26. Graessler J, Graessler A, Unger S, et al. Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. Arthritis Rheum. 2006;54:292-300.
27. Parsa A, Brown E, Weir MR, et al. Genotype-based changes in serum uric acid affect blood pressure. Kidney Int. 2012;81:502-507.
28. Cannella AC, Mikuls TR. Understanding treatments for gout. Am J Manag Care. 2005;11:S451-S458.
29. Lee JE, Kim YG, Choi YH, et al. Serum uric acid is associated with microalbuminuria in prehypertension. Hypertension. 2006;47:962-967.
30. Schlesinger N. Dietary factors and hyperuricaemia. Curr Pharm Des. 2005;11:4133-4138.
31. Hwang LC, Tsai CH, Chen TH. Overweight and obesity-related metabolic disorders in hospital employees. J Formos Med Assoc. 2006;105:56-63.
32. Masseoud D, Rott K, Liu-Bryan R, Agudelo C. Overview of hyperuricaemia and gout. Curr Pharm Des. 2005;11:4117-4124.
33. Rho YH, Zhu Y, Choi HK. The epidmeiology of uric acid and fructose. Semin Nephrol. 2011;31:410-419.
34. Nakagawa T, Hu H, Zharikov S, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol. 2006;290:F625-F631.
35. Fox IH, Kelley WN. Studies on the mechanism of fructose-induced hyperuricemia in man. Metabolism. 1972;21:713-721.
36. Hwang IS, Ho H, Hoffman BB, Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension. 1987;10:512-516.
37. Johnson RJ, Perez-Pozo SE, Sautin YY, et al. Excessive fructose intake, uric acid and the etiology of type 2 diabetes. Endocrin Rev. 2009;30:96-116.
38. Brown C, Culloo A, Yepuri G, Montani J. Fructose ingestion acutely elevates blood pressure in healthy young humans. Am J Physiol Regul Integr Comp Physiol. 2008;294:R730-R737.
39. Nguyen S, Choi H, Lustig R, Hsu C. The association of sugar sweetened beverage consumption on serum uric acid and blood pressure in a nationally representative sample of adolescents. J Pediatr. 2009;154(6):807-813.
40. Jalal D, Smits G, Johnson RJ, Chonchol M. Increased fructose intake associates with elevated blood pressure. J Amer Soc Nephrol. 2010;21:1543-1549.
41. Perez-Pozo SE, Schold J, Nakagawa T, et al. Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int J Obes (Lond). 2010;34(3):454-461.
42. Mazzali M, Hughes J, Kim YG, et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension. 2001;38:1101-1106.
43. Mazzali M, Kanellis J, Han L, et al. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol. 2002;282:F991-F997.
44. Sanchez-Lozada LG, Tapia E, Lopez-Molina R, et al. Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. Am J Physiol Renal Physiol. 2007;292:F1238-F1244.
45. Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol. 2007;293:C584-C596.
46. Gersch MS, Mu W, Cirillo P, et al. Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am J Physiol Renal Physiol. 2007;293:F1256-F1261.
47. Watanabe S, Kang DH, Feng L, et al. Uric acid hominoid evolution and the pathogenesis of salt-sensitivity. Hypertension. 2002;40:355-360.
48. Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol. 2005;16:3553-3562.
49. Kang DH, Nakagawa T, Feng L, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002;13:2888-2897.
50. Kanellis J, Watanabe S, Li JH, et al. Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension. 2003;41:1287-1293.
51. Price K, Sautin Y, Long D, et al. Human vascular smooth muscle cells express a urate transporter. J Am Soc Nephrol. 2006;17:1791-1795.
52. Rovda IuI, Kazakova LM, Plaksina EA. [Parameters of uric acid metabolism in healthy children and in patients with arterial hypertension]. Pediatriia. 1990;(8):19-22.
53. Gruskin AB. The adolescent with essential hypertension. Am J Kidney Dis. 1985;6:86-90.
54. Feig DI, Johnson RJ. Hyperuricemia in childhood primary hypertension. Hypertension. 2003;42:247-252.
55. Laszlo J. Current management of polycythemia vera and related diseases. Postgrad Med. 1974;55:168-173.
56. Szmigiel Z, Pawlicka G, Sowa M. [Clinical effects of purine metabolism disorders in hematopoietic proliferative diseases]. Pol Tyg Lek. 1976;31:2119-2122.
57. Feig DI, Nakagawa T, Karumanchi SA, et al. Hypothesis: Uric acid, nephron number and the pathogenesis of essential hypertension. Kidney Int. 2004;66:281-287.
58. Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA. 2008;300:924-932.
59. Chen L, Caballer B, Mitchell DC, et al. Reducing consumption of sugar-sweetened beverages is associated with reduced blood pressure: a prospective study among United States adults. Circulation. 2010;121:2398-2406.
60. Fessel WJ, Siegelaub AB, Johnson ES. Correlates and consequences of asymptomatic hyperuricemia. Arch Intern Med. 1973;132:144-154.
61. Brand FN, McGee DL, Kannel WB, et al. Hyperuricemia as a risk factor of coronary heart disease: the Framingham Study. Am J Epidemiol. 1985;121:11-18.
62. Selby JV, Friedman GD, Quesenberry CP Jr. Precursors of essential hypertension: pulmonary function, heart rate, uric acid, serum cholesterol, and other serum chemistries. Am J Epidemiol. 1990;131:1017-1027.
63. Hunt SC, Stephenson SH, Hopkins PN, Williams RR. Predictors of an increased risk of future hypertension in Utah. A screening analysis. Hypertension. 1991;17:969-976.
64. Jossa F, Farinaro E, Panico S, et al. Serum uric acid and hypertension: the Olivetti heart study. J Hum Hypertens. 1994;8:677-681.
65. Perlstein TS, Gumieniak O, Williams GH, et al. Uric acid and the development of hypertension: the normative aging study. Hypertension. 2006;48:1031-1036.
66. Mellen PB, Bleyer AJ, Erlinger TP, et al. Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study. Hypertension. 2006;48:1037-1042.
67. Shankar A, Klein R, Klein BE, Nieto FJ. The association between serum uric acid level and long-term incidence of hypertension: population-based cohort study. J Hum Hypertens. 2006;20:937-945.
68. Forman JP, Choi H, Curhan GC. Plasma uric acid level and risk for incident hypertension among men. J Am Soc Nephrol. 2007;18:287-292.
69. Krishnan E, Kwoh CK, Schumacher HR, Kuller L. Hyperuricemia and incidence of hypertension among men without metabolic syndrome. Hypertension. 2007;49:298-303.
70. Forman JP, Choi H, Curhan GC. Uric acid and insulin sensitivity and risk of incident hypertension. Arch Intern Med. 2009;169:155-162.
71. Zhang W, Sun K, Yang Y, et al. Plasma uric acid and hypertension in a Chinese community: prospective study and metaanalysis. Clin Chem. 2009;55:2026-2034.
72. Jones DP, Richey PA, Alpert BS. Comparison of ambulatory blood pressure reference standards in children evaluated for hypertension. Blood Pressure Monit. 2009;14:103-107.
73. Leite MA. Uric acid and fibrinogen: age-modulated relationships with blood pressure components. J Human Hypertens. 2011;25:476-483.
74. Grayson PC, Kim SY, Lavalley M, Choi HK. Hyperuricemia and incident hypertension: a systematic review and meta-analysis. Arthritis Care Res. 2011;63:102-110.
75. Jolly SE, Mete M, Wang H, et al. Uric acid, hypertension and chronic kidney disease among Alaska Eskimos: the Genetics of Coronary Artery Disease in Alaska natives (GOCADAN) Study. J Clin Hypertens. 2012;14:71-77.
76. Loeffler LF, Navas-Acien A, Brady TM, et al. Uric acid level and elevated blood pressure in US adolescents. Hypertension. 2012;59:811-817.